1-Acetylpiperidin-4-amine
Uses- Product Name
- 1-Acetylpiperidin-4-amine
- CAS No.
- 160357-94-8
- Chemical Name
- 1-Acetylpiperidin-4-amine
- Synonyms
- 4-Amino-N-1-acetylpiperidine;1-ACETYLPIPERIDIN-4-AMINE;4-Piperidinamine, 1-acetyl-;4-AMINO-1-ACETYL-PIPERIDINE;1-ACETYL-4-AMINO-PIPERIDINE;1-N-Acetyl-4-aminopiperidine;1-Acetyl-4-piperidinyl)amine;1-Acetyl-4-aminopiperidine 97%;1-Acetyl-4-aminopiperidine,>97%;1-(4-Aminopiperidino)-1-ethanone
- CBNumber
- CB2146067
- Molecular Formula
- C7H14N2O
- Formula Weight
- 142.2
- MOL File
- 160357-94-8.mol
1-Acetylpiperidin-4-amine Property
- Boiling point:
- 273.6±33.0 °C(Predicted)
- Density
- 1.042±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.37±0.20(Predicted)
- form
- oil
- color
- Colourless to light yellow
- InChI
- InChI=1S/C7H14N2O/c1-6(10)9-4-2-7(8)3-5-9/h7H,2-5,8H2,1H3
- InChIKey
- NLHBHVGPMMXWIM-UHFFFAOYSA-N
- SMILES
- C(=O)(N1CCC(N)CC1)C
- CAS DataBase Reference
- 160357-94-8(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- A3613
- Product name
- 1-(4-Aminopiperidin-1-yl)ethan-1-one
- Purity
- min. 95.0 %
- Packaging
- 200MG
- Price
- $40
- Updated
- 2025/07/31
- Product number
- A3613
- Product name
- 1-(4-Aminopiperidin-1-yl)ethan-1-one
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $120
- Updated
- 2025/07/31
- Product number
- A192255
- Product name
- 1-Acetyl-4-aminopiperidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 031023
- Product name
- 1-(4-Aminopiperidino)-1-ethanone
- Packaging
- 1g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- OR17566
- Product name
- 1-Acetyl-4-aminopiperidine
- Purity
- 97%
- Packaging
- 1g
- Price
- $57
- Updated
- 2021/12/16
1-Acetylpiperidin-4-amine Chemical Properties,Usage,Production
Uses
1-Acetyl-4-aminopiperidine is a heterocyclic organic compound with a density of 1.042 g/cm3 and a boiling point of 273.6ºCat760 mmHg. It is an important intermediate in the synthesis of piperidine drugs.
Synthesis
135581-16-7
160357-94-8
General procedure for the synthesis of 4-amino-N-1-acetylpiperidine from 1-acetylpiperidin-4-one (CAS: 135581-16-7, 10 g, 70 mmol): 1. Oximization reaction: 1-acetylpiperidin-4-one was dissolved in 200 mL of ethanol, hydroxylamine hydrochloride (10 g, 143 mmol) and pyridine (10 mL) were added. The reaction mixture was heated to 70 °C and maintained for 1.5 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was treated with cold water and cooled to 0 °C. The resulting slurry was filtered and dried under vacuum to give 1-acetylpiperidin-4-one oxime (6.5 g, white solid, 59% yield). 2. Hydrogenation reaction: The oxime (2.0 g, 12 mmol) prepared above was dissolved in 50 mL of ethanol, and nickel ruanne (0.2 g) was added after being washed several times with water. The mixture was transferred to a Parr reactor and hydrogenated at 50 psi hydrogen pressure for 16 hours. Upon completion of the reaction, the reaction mixture was carefully filtered and the filtrate was evaporated under reduced pressure to afford 4-amino-N-1-acetylpiperidine (1.7 g, green solid, 100% yield). The product was analyzed by GC-MS, m/z = 142.
References
[1] Patent: WO2004/110996, 2004, A1. Location in patent: Page/Page column 102
[2] Patent: US2008/227780, 2008, A1. Location in patent: Page/Page column 55
1-Acetylpiperidin-4-amine Preparation Products And Raw materials
Raw materials
Preparation Products
1-Acetylpiperidin-4-amine Suppliers
- Tel
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- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 1-Acetylpiperidin-4-amine manufacturers
- Product
- 1-Acetyl-4-amino-piperidine 160357-94-8
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- kgs
- Release date
- 2023-01-03
- Product
- 1-Acetylpiperidin-4-amine 160357-94-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2019-12-24