ChemicalBook > CAS DataBase List > 4-piperidin-3-ylaniline
4-piperidin-3-ylaniline
- Product Name
- 4-piperidin-3-ylaniline
- CAS No.
- 19733-56-3
- Chemical Name
- 4-piperidin-3-ylaniline
- Synonyms
- NiraparibIntermediate3;4-piperidin-3-ylaniline;3-(4-Aminophenyl)piperidine;4-Piperidin-3-yl-phenylamine;4-(piperidin-3-yl)benzenamine;Benzenamine, 4-(3-piperidinyl)-;RSYY（Donepezil Hydrochloride)-10
- CBNumber
- CB21465114
- Molecular Formula
- C11H16N2
- Formula Weight
- 176.26
- MOL File
- 19733-56-3.mol
More
Less
4-piperidin-3-ylaniline Property
- Melting point:
- 96-97 °C
- Boiling point:
- 331.9±35.0 °C(Predicted)
- Density
- 1.043±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 10.26±0.10(Predicted)
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
TRC
- Product number
- P479855
- Product name
- 4-(Piperidin-3-yl)aniline
- Packaging
- 100mg
- Price
- $330
- Updated
- 2021/12/16
TRC
- Product number
- P479855
- Product name
- 4-(Piperidin-3-yl)aniline
- Packaging
- 250mg
- Price
- $570
- Updated
- 2021/12/16
AK Scientific
- Product number
- 2533AJ
- Product name
- 4-(Piperidin-3-yl)aniline
- Packaging
- 250mg
- Price
- $331
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- CHM0386051
- Product name
- 4-(PIPERIDIN-3-YL)ANILINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.01
- Updated
- 2021/12/16
Crysdot
- Product number
- CD11170913
- Product name
- 4-(Piperidin-3-yl)aniline
- Purity
- 95+%
- Packaging
- 1g
- Price
- $515
- Updated
- 2021/12/16
More
Less
4-piperidin-3-ylaniline Chemical Properties,Usage,Production
Uses
4-(Piperidin-3-yl)aniline is a reagent in the development of the fit-for-purpose large-scale synthesis of oral PARP inhibitor.
Synthesis
4282-46-6
19733-56-3
General procedure for the synthesis of 4-(piperidin-3-yl)aniline from 3-(4-nitrophenyl)pyridine: 3-(4-nitrophenyl)pyridine (20.0 g), methanol (180 mL), and 0.1 M hydrochloric acid were added to a hydrogenation reactor, and the reaction was carried out by the method described in reference to the literature (Org. Process Res. Dev. 2011, 15, 831-840) . This was done as follows: 3-(4-nitrophenyl)pyridine was added to the reactor, followed by the addition of PtO2 (2 g). The reaction system was evacuated and displaced with nitrogen, and then the reaction mixture was cooled to 10 °C. The reaction mixture was heated to 40 °C with continuous stirring for 18 hours. After completion of the reaction, the mixture was cooled to room temperature, neutralized with sodium hydroxide solution, extracted with isopropyl acetate and the extract was concentrated to give the product.The yield of N-(4-(pyridin-3-yl)phenyl)hydroxylamine was 4.2%.
References
[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 22, p. 7170 - 7185
[2] Patent: CN106432054, 2017, A. Location in patent: Paragraph 0045; 0046
[3] Organic Process Research and Development, 2011, vol. 15, # 4, p. 831 - 840
[4] Patent: CN106432055, 2017, A
[5] Patent: CN106749181, 2017, A
4-piperidin-3-ylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
4-piperidin-3-ylaniline Suppliers
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 028-028-60651388 13330964498
- slyu@hengkangtech.com
- Country
- China
- ProdList
- 378
- Advantage
- 58
- Tel
- 13817485796
- Fax
- QQ:895624079
- tim@wisacheampharm.com
- Country
- China
- ProdList
- 3592
- Advantage
- 58
- Tel
- 052386810091
- zcwy9518@yeah.net
- Country
- China
- ProdList
- 3912
- Advantage
- 58
- Tel
- 028-83379370 13880556291
- Fax
- 028-87747383
- tcy@tcypharm.com
- Country
- China
- ProdList
- 7218
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 021-65232103 17602124823
- combiphos@vip.qq.com
- Country
- China
- ProdList
- 30000
- Advantage
- 58
- Tel
- +86-（0）57185586718; +8613336195806
- Fax
- +86-571-85864795
- sales@capot.com
- Country
- China
- ProdList
- 29735
- Advantage
- 60
- Tel
- 025-58859352 18068836627
- Fax
- (5)02557626880
- dt3@aikonchem.com
- Country
- China
- ProdList
- 15493
- Advantage
- 58
- Tel
- 0371-55051623 18137891487
- Fax
- QQ：2853979817
- 2853979817@qq.com
- Country
- China
- ProdList
- 9988
- Advantage
- 58
- Tel
- 18962082606
- Fax
- QQ: 3394205705
- 3394205705@qq.com
- Country
- China
- ProdList
- 1751
- Advantage
- 58
- Tel
- 0523-86848872 19952992164
- Fax
- 0523-86848872
- 725236090@qq.com
- Country
- China
- ProdList
- 97
- Advantage
- 58
- Tel
- 18254155803
- 1066867490@qq.com
- Country
- CHINA
- ProdList
- 55
- Advantage
- 58
- Tel
- 18621609968
- 1162686636@qq.com
- Country
- China
- ProdList
- 876
- Advantage
- 58
- Tel
- zhiqianbio@126.com
- Country
- China
- ProdList
- 19778
- Advantage
- 58
- Tel
- +8615866703830
- figo.gao@foxmail.com
- Country
- China
- ProdList
- 8497
- Advantage
- 58
- Tel
- +1-2135480471
- sales@sarms4muscle.com
- Country
- China
- ProdList
- 10473
- Advantage
- 58
- Tel
- +86-0551-65418671 +8618949823763
- Fax
- 0551-65418697
- sales@tnjchem.com
- Country
- China
- ProdList
- 34563
- Advantage
- 58
- Tel
- 0531-0531-69900633 19963472814
- changyuan20@163.com
- Country
- China
- ProdList
- 2742
- Advantage
- 58
- Tel
- 86-21-51086038
- Fax
- 86-21-51861608
- chemwill_asia@126.com
- Country
- CHINA
- ProdList
- 23912
- Advantage
- 58
- Tel
- 037188900765 18037465274
- Fax
- QQ3430974218
- enyawanglei@sina.cn
- Country
- China
- ProdList
- 13966
- Advantage
- 58
- Tel
- 18550739526
- Fax
- QQ: 3394205705
- 23903480@qq.com
- Country
- China
- ProdList
- 5840
- Advantage
- 58
- Tel
- +86-023-6139-8061 +86-86-13650506873
- sales@chemdad.com
- Country
- China
- ProdList
- 39927
- Advantage
- 58
- Tel
- 021-021-54331997 18321536537
- info@ansionpharma.com
- Country
- China
- ProdList
- 2336
- Advantage
- 58
- Tel
- 21-33585366
- Fax
- +86-21-34979012
- export01@shyrchem.com
- Country
- CHINA
- ProdList
- 1319
- Advantage
- 58
- Tel
- 18012778619
- 3394205705@qq.com
- Country
- China
- ProdList
- 9841
- Advantage
- 58
- Tel
- 13981731671
- checo@checopharma.com
- Country
- China
- ProdList
- 363
- Advantage
- 58
- Tel
- +86-0519-85551759 +8613506123987
- Fax
- +0086-519-85557389
- marketing1@neostarunited.com
- Country
- China
- ProdList
- 8830
- Advantage
- 58
- Tel
- 021-64340559 13651849907
- Fax
- 021-64345308
- xinyu_shi@jwypharmlab.com.cn
- Country
- China
- ProdList
- 9381
- Advantage
- 58
- Tel
- 13000000000
- jnxinhongtai@126.com
- Country
- China
- ProdList
- 19528
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44894
- Advantage
- 58
- Tel
- 1701086315
- Fax
- 1701086315@qq.com
- dexuanpharma@126.com
- Country
- China
- ProdList
- 9475
- Advantage
- 58
- Tel
- +86-02787215551 +86-19945035818
- Fax
- 027-87215551
- 2936752263@qq.com
- Country
- China
- ProdList
- 7986
- Advantage
- 58
- Tel
- 021-51816796-820 13611835272
- Fax
- 021-5161 3951
- sales2@sunwaypharm.com
- Country
- China
- ProdList
- 44119
- Advantage
- 58
- Tel
- 400-6005915
- sales@picasso-e.com
- Country
- China
- ProdList
- 39653
- Advantage
- 58
- Tel
- 15996452985
- foxerhy@163.com
- Country
- China
- ProdList
- 4939
- Advantage
- 58
- Tel
- 15387063101
- 2881924050@qq.com
- Country
- China
- ProdList
- 9960
- Advantage
- 58
- Tel
- 15553348166
- m15553348166@163.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 0751-2838688 13376594225
- 1276075424@qq.com
- Country
- China
- ProdList
- 9942
- Advantage
- 58
- Tel
- 400-8210725 4008210725
- malulu@leyan.com
- Country
- China
- ProdList
- 40000
- Advantage
- 58
- Tel
- 19821570922
- angela@labgogo.com
- Country
- China
- ProdList
- 9896
- Advantage
- 58
- Tel
- 021-57520305 13795461237
- zhuruyan@jskchem.com
- Country
- China
- ProdList
- 49234
- Advantage
- 58
- Tel
- 4000255188
- sales@pharmablock.com
- Country
- China
- ProdList
- 7268
- Advantage
- 58
- Tel
- 13393721940
- sales@vcommend.com
- Country
- China
- ProdList
- 9963
- Advantage
- 58
- Tel
- 13419562052 13419562052
- wwmlyb@163.com
- Country
- China
- ProdList
- 3932
- Advantage
- 58
- Tel
- 17316404525 17316404525
- 209533805@qq.com
- Country
- China
- ProdList
- 9766
- Advantage
- 58
- Tel
- 029-81136151 17392212881
- 1095@dideu.com
- Country
- China
- ProdList
- 10001
- Advantage
- 58
- Tel
- 0751-2815983 13927872582
- Fax
- 0751-2886750
- 2787852318@qq.com
- Country
- China
- ProdList
- 8065
- Advantage
- 58
- Tel
- 0826-5999982 15102825326
- may.yang@taienkangpharma.com
- Country
- China
- ProdList
- 365
- Advantage
- 58
- Tel
- 15380796838
- chloewu@chicopharm.cn
- Country
- CHINA
- ProdList
- 340
- Advantage
- 58
More
Less
View Lastest Price from 4-piperidin-3-ylaniline manufacturers
Career Henan Chemical Co
- Product
- 4-piperidin-3-ylaniline 19733-56-3
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-31
19733-56-3, 4-piperidin-3-ylanilineRelated Search:
(S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-carboxaMide
4-(3-PYRIDYL)ANILINE
N-(tert-butyl)-1H-indazole-7-carboxamide
3-(4-AMINO-PHENYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(R)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate
4-(3-Piperidyl)aniline Dihydrochloride
1H-indazole-7-carboxylic acid
tert-butyl (S)-3-(4-bromophenyl)piperidine-1-carboxylate
Niraparib
(S)-tert-butyl 3-(4-aMinophenyl)piperidine-1-carboxylate
(R)-1-(2-(2,5-dichlorobenzamido)acetamido)-3-methylbutylboronic acid
Piperidine, 3-(4-bromophenyl)-
(aR,3aS,4S,6S,7aR)-Hexahydro-3a,8,8-trimethyl-alpha-(2-methylpropyl)-4,6-methano-1,3,2-benzodioxaborole-2-methanamine 2,2,2-trifluoroacetate
CHEMBRDG-BB 7959525
Methyl 3-formyl-2-nitrobenzoate