ChemicalBook > CAS DataBase List > Ethyl (3-fluorobenzoyl)acetate

Ethyl (3-fluorobenzoyl)acetate

Product Name: Ethyl (3-fluorobenzoyl)acetate
CAS No.: 33166-77-7
Chemical Name: Ethyl (3-fluorobenzoyl)acetate
Synonyms: Ethyl m-fluorobenzoyl acetate;Ethyl 2-3-fluorobenzoylacetate;ETHYL (3-FLUOROBENZOYL)ACETATE;Ethyl 3-fluoro-β-oxobenzenepropanoate;(m-Fluorobenzoyl)acetic acid ethyl ester;ETHYL 3-(3-FLUOROPHENYL)-3-OXOPROPANOATE;3-(3-Fluorophenyl)-3-oxopropanoic acid ethyl ester;Benzenepropanoic acid, 3-fluoro-β-oxo-, ethyl ester;Benzenepropanoic acid, 3-fluoro-β-oxo-, ethyl ester;3-（3-Fluoro-phenyl）-3-oxo-propionic acid ethyl bster
CBNumber: CB2148920
Molecular Formula: C11H11FO3
Formula Weight: 210.2
MOL File: 33166-77-7.mol

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Ethyl (3-fluorobenzoyl)acetate Property

Boiling point:: 262-263 °C(lit.)
Density: 1.166 g/mL at 25 °C(lit.)
refractive index: n20/D 1.5172(lit.)
Flash point:: >230 °F
storage temp.: Sealed in dry,Room Temperature
form: Liquid
pka: 10.10±0.46(Predicted)
color: Colorless to orange
CAS DataBase Reference: 33166-77-7(CAS DataBase Reference)

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Safety

WGK Germany: 3
TSCA: Yes
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 559237
Product name: Ethyl (3-fluorobenzoyl)acetate
Packaging: 1g
Price: $96.1
Updated: 2023/06/20

Sigma-Aldrich

Product number: 559237
Product name: Ethyl (3-fluorobenzoyl)acetate
Packaging: 5g
Price: $230
Updated: 2023/01/07

TRC

Product number: F596370
Product name: 3-(3-Fluoro-phenyl)-3-oxo-propionicacidethylester
Packaging: 1g
Price: $75
Updated: 2021/12/16

AK Scientific

Product number: J51488
Product name: Ethyl (3-fluorobenzoyl)acetate
Packaging: 10g
Price: $315
Updated: 2021/12/16

Matrix Scientific

Product number: 089846
Product name: Ethyl 3-(3-fluorophenyl)-3-oxopropanoate
Purity: 95+%
Packaging: 5g
Price: $504
Updated: 2021/12/16

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Ethyl (3-fluorobenzoyl)acetate Chemical Properties,Usage,Production

Uses

Reactant for:

Preparation of biologically active molecules

Synthesis

To a stirring suspension of NaH and CO(OEt)2 in toluene was added dropwise a solution of substituted acetophenone in toluene under reflux. The mixture was allowed to reflux and was stirred for 20 min after the addition was complete. When cooled to room temperature, the mixture was acidified with glacial HOAc. After ice-cold water was added, the mixture was extracted with toluene. The extract was then dried over anhydrous MgS04. After the toluene was evaporated in vacuo to give the corresponding substituted Ethyl (3-fluorobenzoyl)acetate.

References

[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5064 - 5075
[2] Patent: WO2014/179401, 2014, A1. Location in patent: Page/Page column 9; 14; 15
[3] Journal of Medicinal Chemistry, 1997, vol. 40, # 19, p. 3049 - 3056
[4] European Journal of Organic Chemistry, 2015, vol. 2015, # 17, p. 3656 - 3660
[5] Chemical Communications, 2017, vol. 53, # 58, p. 8136 - 8139

Ethyl (3-fluorobenzoyl)acetate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl (3-fluorobenzoyl)acetate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 33166-77-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-02

Career Henan Chemical Co

Product: 3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER 33166-77-7
Price: US $1.00/g
Min. Order: 100EA
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-23

33166-77-7, Ethyl (3-fluorobenzoyl)acetateRelated Search:

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3-(3-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER

ETHYL 3-(3-FLUOROPHENYL)-3-OXOPROPANOATE

ETHYL (3-FLUOROBENZOYL)ACETATE

(m-Fluorobenzoyl)acetic acid ethyl ester

3-(3-Fluorophenyl)-3-oxopropanoic acid ethyl ester

Ethyl 2-3-fluorobenzoylacetate

Ethyl 3-fluoro-β-oxobenzenepropanoate

Ethyl m-fluorobenzoyl acetate

Benzenepropanoic acid, 3-fluoro-β-oxo-, ethyl ester

3-（3-Fluoro-phenyl）-3-oxo-propionic acid ethyl bster

Benzenepropanoic acid, 3-fluoro-β-oxo-, ethyl ester

33166-77-7

FC6H4COCH2CO2C2H5

Esters

Organic Building Blocks

C10 to C11

Carbonyl Compounds

Building Blocks

C10 to C11

Carbonyl Compounds

Esters