ChemicalBook > CAS DataBase List > 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

Product Name
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
CAS No.
230615-23-3
Chemical Name
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
Synonyms
ChaMpix hydrochloride;Chantix hydrochloride;CP 526555 hydrochloride;Varenicline hydrochloride;CP 526555 HYDROCHLORIDE; CHAMPIX HYDROCHLORIDE; CHANTIX HYDROCHLORIDE;7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride;5,8,14-TRIAZATETRACYCLO[10.3.1.0(2,11).0(4,9)]HEXADECA-2(11),3,5,7,9-PENT+;6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride;6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride;6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
CBNumber
CB21512571
Molecular Formula
C13H14ClN3
Formula Weight
247.73
MOL File
230615-23-3.mol
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6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Property

storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0828
Product name
Varenicline(Hydrochloride)
Purity
98.87%
Packaging
5mg
Price
$84
Updated
2021/12/16
Biosynth Carbosynth
Product number
FV152325
Product name
Varenicline hydrochloride
Packaging
10mg
Price
$85
Updated
2021/12/16
ApexBio Technology
Product number
B1141
Product name
VareniclineHydrochloride
Packaging
5mg
Price
$119
Updated
2021/12/16
ChemScene
Product number
CS-0828
Product name
Varenicline(Hydrochloride)
Purity
98.87%
Packaging
10mg
Price
$120
Updated
2021/12/16
ApexBio Technology
Product number
B1141
Product name
VareniclineHydrochloride
Packaging
10mg
Price
$189
Updated
2021/12/16
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6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Chemical Properties,Usage,Production

Uses

Varenicline Hydrochloride is a useful nicotine binding inhibitor.

Biological Activity

varenicline hydrochloride is a partial agonist of α4β2 nicotinic receptor for smoking cessation [1].varenicline hydrochloride has been reported to potently inhibit nachr binding with the ki values of 0.12±0.02 nm and 0.14±0.01 nm for α6β2* nachr and α4β2* nachr, respectively in rat striatum, 0.13±0.01 nm and 0.19±0.11 nm forα6β2* nachr and α4β2* nachr, respectively in monkey striatum. in addition, varenicline hydrochloride has shown to be more potent in stimulating both α6β2* and α4β2* nachrs compared with nicotine with the ec50 values of 0.007 and 0.086μm, respectively in rat striatum [1].

References

[1] bordia t1, hrachova m, chin m, mcintosh jm, quik m. varenicline is a potent partial agonist at α6β2* nicotinic acetylcholine receptors in rat and monkey striatum. j pharmacol exp ther. 2012 aug;342(2):327-34. doi: 10.1124/jpet.112.194852. epub 2012 may 1.

6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride Suppliers

China 41 India 1 United Kingdom 1 United States 7 Global 50
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View Lastest Price from 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride manufacturers

Career Henan Chemical Co
Product
6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride 230615-23-3
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-20

230615-23-3, 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochlorideRelated Search:

Varenicline-d4 Dihydrochloride (Major) Varenicline Lactam Varenicline N-Glucoside Varenicline Carbamoyl β-D-Glucuronide 6,7-DIMETHYLQUINOXALINE 10-AZA-TRICYCLO[6.3.1.0]DODECA-2,4,6-TRIENE TOSYLATE 2,3,4,5-TETRAHYDRO-1H-1,5-METHANO-3-BENZAZEPINE HYDROCHLORIDE Varenicline 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride

  • 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-, monohydrochloride
  • 6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride (Varenicline hydrochloride)
  • CP 526555 HYDROCHLORIDE; CHAMPIX HYDROCHLORIDE; CHANTIX HYDROCHLORIDE
  • 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 6,7,8,9-tetrahydro-,monohydrochloride (Varenicline Hcl)
  • Varenicline hydrochloride
  • 6,7,8,9-Tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine hydrochloride
  • 5,8,14-TRIAZATETRACYCLO[10.3.1.0(2,11).0(4,9)]HEXADECA-2(11),3,5,7,9-PENT+
  • 6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine, 7,8,9,10-tetrahydro-, hydrochloride (1:1)
  • 7,8,9,10-tetrahydro-6H-6,10-methanoazepino[4,5-g]quinoxaline hydrochloride
  • 6,7,8,9-tetrahydro-6,10-Methano-6H-pyrazino[2,3-h][3]benzazepine Monohydrochloride
  • ChaMpix hydrochloride
  • Chantix hydrochloride
  • CP 526555 hydrochloride
  • 230615-23-3
  • C13H13N3HCl
  • API intermediates