4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
- Product Name
- 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
- CAS No.
- 136624-42-5
- Chemical Name
- 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
- Synonyms
- 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE;4-amino-1-(phenylmethyl)-4-piperidinecarbonitrile;4-Piperidinecarbonitrile, 4-amino-1-(phenylmethyl)-
- CBNumber
- CB21519196
- Molecular Formula
- C13H17N3
- Formula Weight
- 215.29
- MOL File
- 136624-42-5.mol
4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Property
- Boiling point:
- 358.0±42.0 °C(Predicted)
- Density
- 1.12±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 6.22±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- A595153
- Product name
- 4-amino-1-benzylpiperidine-4-carbonitrile
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- X9952
- Product name
- 4-Amino-1-benzylpiperidine-4-carbonitrile
- Packaging
- 250mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 145291
- Product name
- 4-Amino-1-benzylpiperidine-4-carbonitrile
- Purity
- 95%
- Packaging
- 250mg
- Price
- $533
- Updated
- 2021/12/16
- Product number
- X9952
- Product name
- 4-Amino-1-benzylpiperidine-4-carbonitrile
- Packaging
- 1g
- Price
- $652
- Updated
- 2021/12/16
- Product number
- 145291
- Product name
- 4-Amino-1-benzylpiperidine-4-carbonitrile
- Purity
- 95%
- Packaging
- 1g
- Price
- $903
- Updated
- 2021/12/16
4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Chemical Properties,Usage,Production
Synthesis
773837-37-9
3612-20-2
136624-42-5
Step A: Synthesis of 4-amino-1-benzylpiperidine-4-carbonitrile To a solution of ammonium chloride (17.3 g, 323 mmol) in water (200 mL) was sequentially added 25% ammonia (25 mL, 332 mmol) and 1-benzylpiperidin-4-one (11.43 g, 60 mmol). The resulting mixture was stirred at room temperature for 20 minutes, followed by the addition of sodium cyanide (14.7 g, 300 mmol) in batches over 15 minutes. The reaction mixture was stirred at room temperature for 24 hours and then partitioned between water (200 mL) and dichloromethane (2 x 200 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (silica gel, elution gradient: 50% ethyl acetate/heptane to 100% ethyl acetate) to afford 4-amino-1-benzylpiperidine-4-carbonitrile (6.15 g, 47% yield). 1H NMR (300 MHz, CDCl3) δ ppm: 1.69-1.86 (m, 4H), 2.00 (dt, J = 13.1, 2.1 Hz, 2H), 2.27-2.45 (m, 2H), 2.83 (dt, J = 12.4, 3.6 Hz, 2H), 3.55 (s, 2H), 7.21-7.39 (m. 5H); MS m/z 216 (M + H)+.
References
[1] ACS Combinatorial Science, 2016, vol. 18, # 6, p. 330 - 336
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 14, p. 4719 - 4722
[3] Patent: WO2014/39769, 2014, A1. Location in patent: Page/Page column 286-287
[4] Patent: US2015/99730, 2015, A1. Location in patent: Paragraph 0723; 0724
[5] Patent: US2010/130506, 2010, A1. Location in patent: Page/Page column 108
4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Preparation Products And Raw materials
Raw materials
Preparation Products
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