ChemicalBook > CAS DataBase List > 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE

4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE

Product Name: 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
CAS No.: 136624-42-5
Chemical Name: 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE
Synonyms: 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE;4-amino-1-(phenylmethyl)-4-piperidinecarbonitrile;4-Piperidinecarbonitrile, 4-amino-1-(phenylmethyl)-
CBNumber: CB21519196
Molecular Formula: C13H17N3
Formula Weight: 215.29
MOL File: 136624-42-5.mol

Less

4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Property

Boiling point:: 358.0±42.0 °C(Predicted)
Density: 1.12±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 6.22±0.10(Predicted)
Appearance: White to off-white Solid

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

TRC

Product number: A595153
Product name: 4-amino-1-benzylpiperidine-4-carbonitrile
Packaging: 50mg
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: X9952
Product name: 4-Amino-1-benzylpiperidine-4-carbonitrile
Packaging: 250mg
Price: $305
Updated: 2021/12/16

Matrix Scientific

Product number: 145291
Product name: 4-Amino-1-benzylpiperidine-4-carbonitrile
Purity: 95%
Packaging: 250mg
Price: $533
Updated: 2021/12/16

AK Scientific

Product number: X9952
Product name: 4-Amino-1-benzylpiperidine-4-carbonitrile
Packaging: 1g
Price: $652
Updated: 2021/12/16

Matrix Scientific

Product number: 145291
Product name: 4-Amino-1-benzylpiperidine-4-carbonitrile
Purity: 95%
Packaging: 1g
Price: $903
Updated: 2021/12/16

Less

4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Chemical Properties,Usage,Production

Synthesis

773837-37-9

3612-20-2

136624-42-5

Step A: Synthesis of 4-amino-1-benzylpiperidine-4-carbonitrile To a solution of ammonium chloride (17.3 g, 323 mmol) in water (200 mL) was sequentially added 25% ammonia (25 mL, 332 mmol) and 1-benzylpiperidin-4-one (11.43 g, 60 mmol). The resulting mixture was stirred at room temperature for 20 minutes, followed by the addition of sodium cyanide (14.7 g, 300 mmol) in batches over 15 minutes. The reaction mixture was stirred at room temperature for 24 hours and then partitioned between water (200 mL) and dichloromethane (2 x 200 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (silica gel, elution gradient: 50% ethyl acetate/heptane to 100% ethyl acetate) to afford 4-amino-1-benzylpiperidine-4-carbonitrile (6.15 g, 47% yield). 1H NMR (300 MHz, CDCl3) δ ppm: 1.69-1.86 (m, 4H), 2.00 (dt, J = 13.1, 2.1 Hz, 2H), 2.27-2.45 (m, 2H), 2.83 (dt, J = 12.4, 3.6 Hz, 2H), 3.55 (s, 2H), 7.21-7.39 (m. 5H); MS m/z 216 (M + H)+.

References

[1] ACS Combinatorial Science, 2016, vol. 18, # 6, p. 330 - 336
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 14, p. 4719 - 4722
[3] Patent: WO2014/39769, 2014, A1. Location in patent: Page/Page column 286-287
[4] Patent: US2015/99730, 2015, A1. Location in patent: Paragraph 0723; 0724
[5] Patent: US2010/130506, 2010, A1. Location in patent: Page/Page column 108

4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE Suppliers

China 38 India 1 Ukraine 1 United States 5 Global 45

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

Acesys Pharmatech

Tel: 18860950986
Email: tangmanman@zenjipharma.com
Country: China
ProdList: 1733
Advantage: 55

Shanghai Witofly Chemical Co.,Ltd

Tel
Email: sales@witofly.com
Country: China
ProdList: 2864
Advantage: 52

AstaTech (Chengdu) Pharma. Co., Ltd.

Tel: 15928766785 15928766785
Fax: QQ961458712
Email: wupengcheng@astatech.cn
Country: China
ProdList: 1987
Advantage: 55

Shanghai Tombiopharma Chemical Co. Ltd.

Tel: 13391076197
Email: tombiopharma@163.com
Country: China
ProdList: 4987
Advantage: 55

Xi'an NewProChem Co.,Ltd.

Tel: 15332490153
Fax: QQ 2725398181
Email: newprochem@126.com
Country: China
ProdList: 991
Advantage: 55

SanoChem (Chengdu) Tech. Co., Ltd.

Tel: 28-87999436 02887999436
Fax: QQ:2746983436
Email: sales@sano-chem.com
Country: China
ProdList: 3795
Advantage: 55

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 7218
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

BIO-PHARMACY (Wuhan) Co., Ltd.

Tel: 0711-5919292 15307133740
Fax: 0711-5919292
Email: 3451683016@qq.com
Country: China
ProdList: 1069
Advantage: 58

Aikon International Limited

Tel: 025-66061636 18013972705
Fax: (3)02557626880
Email: qqyang@aikonchem.com
Country: China
ProdList: 15814
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Nanjing SynTitan Pharmaceutical Co., Ltd.

Tel: 025-57027686 17372956142
Fax: 025-57027686
Email: li_lan@syntitan.com
Country: China
ProdList: 9998
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Chengdu Feibai Pharmaceutical Co., Ltd.

Tel: 028-84641798 18782128315
Email: 3302391190@qq.com
Country: China
ProdList: 9799
Advantage: 55

Nanjing Meihao Pharmaceutical Technology Co., Ltd.

Tel: meitaochem@126.com
Email: meitaochem@126.com
Country: China
ProdList: 19103
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Baimei Jihua (Henan) Pharmaceutical Technology Co., Ltd

Tel: 037188900765 18037465274
Fax: QQ3430974218
Email: enyawanglei@sina.cn
Country: China
ProdList: 13966
Advantage: 58

Guizhou Yituo Chemical Technology Co., Ltd

Tel: 18628235590
Fax: QQ:444176500
Email: wuliming@yituochem.cn
Country: China
ProdList: 1242
Advantage: 58

Shanghai Kaiwei Chemical Technology Co., Ltd.

Tel: 021-58461859 15821823057
Email: service@aiviche.com
Country: China
ProdList: 49312
Advantage: 58

Nanjing Becas pharmatech Ltd.

Tel: 13912903754
Email: info@becaspharma.com
Country: China
ProdList: 2763
Advantage: 58

Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo

Tel: 18584079237
Email: 312074905@qq.com
Country: China
ProdList: 2513
Advantage: 58

Guangzhou Yuheng Pharmaceutical Technology Co., Ltd

Tel: +8613580539051
Email: joe@yuhengpharm.com
Country: CHINA
ProdList: 21142
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing@energy-chemical.com
Country: China
ProdList: 44918
Advantage: 58

Shanghai Aizikang Pharmaceutical Research Co., Ltd

Tel: 18721109360
Email: 306685371@qq.com
Country: China
ProdList: 1944
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-6005915
Email: sales@picasso-e.com
Country: China
ProdList: 39653
Advantage: 58

Nanjing Wogni Chemical Co., Ltd.

Tel: 15996452985
Email: foxerhy@163.com
Country: China
ProdList: 4939
Advantage: 58

Heze Aiding Pharmaceutical Co., Ltd

Tel: 17661365138
Email: 2845578351@qq.com
Country: China
ProdList: 7115
Advantage: 58

Huayin Sample Biological Technology Co. LTD

Tel: 13892502238
Email: 1453186328@qq.com
Country: China
ProdList: 803
Advantage: 58

Beijing Solarbio Science & Tecnology Co., Ltd.

Tel: 010-50973130 17801761073
Email: Gsiyu@solarbio.com
Country: China
ProdList: 50464
Advantage: 58

Shanghai Jieshikai Biotechnology Co. , Ltd.

Tel: 021-57520305 13795461237
Email: zhuruyan@jskchem.com
Country: China
ProdList: 49234
Advantage: 58

Shanghai Bai'anmai Material Technology Co., Ltd

Tel: 13656718387
Email: 1556318635@qq.com
Country: China
ProdList: 749
Advantage: 58

Santa Cruz Biotechnology Inc

Tel: 021-60936350
Email: scbt@scbt.com
Country: China
ProdList: 6594
Advantage: 58

GIHI CHEMICALS CO.,LIMITED

Tel: +8618058761490
Email: info@gihichemicals.com
Country: China
ProdList: 49941
Advantage: 58

PT CHEM GROUP LIMITED

Tel: +86-85511178;
Email: peter68@ptchemgroup.com
Country: China
ProdList: 35425
Advantage: 58

Absin Bioscience Inc.

Tel: --
Fax: --
Email: chenjw@absin.cn
Country: CHINA
ProdList: 6208
Advantage: 58

136624-42-5, 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILERelated Search:

N-BOC-4(benzyloxycarbonylaminomethyl)piperidine, 98 % 4-AMINO-1-CBZ-PIPERIDINE-4-CARBOXYLIC ACID 4-AMINO-1-BENZYL-PIPERIDINE-4-CARBOXYLIC ACID AMIDE 1-BENZYLPIPERIDINE-4-CARBONITRILE 4-Amino-1-benzylpiperidine N-BENZYL-4-CYANO-4-(1-PIPERIDINO)-PIPERIDINE, 98 1-benzyl-4-(ethylamino)piperidine-4-carbonitrile 1-BENZYL-4-CYANO-4-(METHYLAMINO)-PIPERIDINE 4-ANILINO-1-BENZYL-4-CYANOPIPERIDINE 4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE

4-AMINO-1-BENZYLPIPERIDINE-4-CARBONITRILE

4-Piperidinecarbonitrile, 4-amino-1-(phenylmethyl)-

4-amino-1-(phenylmethyl)-4-piperidinecarbonitrile

136624-42-5