1-(6-nitropyridin-3-yl)piperazine

Product Name: 1-(6-nitropyridin-3-yl)piperazine
CAS No.: 775288-71-6
Chemical Name: 1-(6-nitropyridin-3-yl)piperazine
Synonyms: AKOS BBV-002250;OTAVA-BB 1314167;Xylulose Impurity 4;1-(6-Nitro-3-pyridyl)piperazine;1-(6-Nitropyridin-3-yl)piperazin;1-(6-Nitro-3-pyridinyl)piperazine;1-(6-nitropyridin-3-yl)piperazine;Piperazine, 1-(6-nitro-3-pyridinyl)-
CBNumber: CB21522600
Molecular Formula: C9H12N4O2
Formula Weight: 208.22
MOL File: 775288-71-6.mol

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1-(6-nitropyridin-3-yl)piperazine Property

Boiling point:: 422.8±40.0 °C(Predicted)
Density: 1.278±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Chloroform; Methanol
form: Solid
pka: 8.50±0.10(Predicted)
color: Yellow
InChI: InChI=1S/C9H12N4O2/c14-13(15)9-2-1-8(7-11-9)12-5-3-10-4-6-12/h1-2,7,10H,3-6H2
InChIKey: UBCDLQPOKISIDX-UHFFFAOYSA-N
SMILES: N1(C2=CC=C([N+]([O-])=O)N=C2)CCNCC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: N519935
Product name: 1-(6-Nitro-3-pyridinyl)piperazine
Packaging: 100mg
Price: $105
Updated: 2021/12/16

AK Scientific

Product number: 2155AC
Product name: 1-(6-Nitropyridin-3-yl)piperazine
Packaging: 250mg
Price: $107
Updated: 2021/12/16

AK Scientific

Product number: 2155AC
Product name: 1-(6-Nitropyridin-3-yl)piperazine
Packaging: 1g
Price: $181
Updated: 2021/12/16

ChemScene

Product number: CS-B0330
Product name: 1-(6-Nitropyridin-3-yl)piperazine
Purity: 99.60%
Packaging: 10g
Price: $680
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0102290
Product name: 1-(6-NITROPYRIDIN-3-YL)PIPERAZINE
Purity: 95.00%
Packaging: 1G
Price: $983.52
Updated: 2021/12/16

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1-(6-nitropyridin-3-yl)piperazine Chemical Properties,Usage,Production

Uses

1-?(6-?Nitro-?3-?pyridinyl)?piperazine is a reagent used in the preparation of highly potent and orally bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine cyclin-dependant kinases as anticancer agents. Also is an impurity of Palbociclib (P139900), an experimental drug for the treatment of breast cancer being developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.

Synthesis

110-85-0

39856-50-3

775288-71-6

GENERAL METHODS: A mixture of 5-bromo-2-nitropyridine (24.7 mmol), piperazine (29.2 mmol) and N,N-diisopropylethylamine (DIPEA, 37.1 mmol) in acetonitrile (100 mL) was refluxed for 8 hours. The reaction progress was monitored by thin layer chromatography (TLC), and after complete conversion of the feedstock, the reaction mixture was cooled to room temperature. The solvent was removed by evaporation and the residue was purified by column chromatography to afford 1-(6-nitropyridin-3-yl)piperazine (8c). The product was a yellow solid in 82% yield.1H NMR (DMSO-d6, 400 MHz) δ: 7.96 (d, J = 9.3 Hz, 1H, Pyr-H), 7.88 (d, J = 2.9 Hz, 1H, Pyr-H), 7.26 (dd, J = 9.3, 3.0 Hz, 1H, Pyr-H), 3.64 (t, 4H, Pyr -NCH2CH2N), 3.32 (t, 4H, Pyr-NCH2CH2N).13C NMR (DMSO-d6, 100 MHz): δ 151.7, 146.2, 136.6, 125.9, 118.4, 51.3, 45.8. High-resolution mass spectrometry (HRMS, ESI): the calculated value for C9H12N4O2 [M + H]+is 209.1039 and the measured value is 209.1030.

References

[1] Journal of Medicinal Chemistry, 2018, vol. 61, # 10, p. 4528 - 4560
[2] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 935 - 945
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 1857 - 1872
[4] Journal of Medicinal Chemistry, 2005, vol. 48, # 7, p. 2388 - 2406
[5] Patent: WO2006/95159, 2006, A1. Location in patent: Page/Page column 77

1-(6-nitropyridin-3-yl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(6-nitropyridin-3-yl)piperazine Suppliers

China 106 India 4 Ukraine 1 United States 4 Global 115

Aladdin Scientific

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Synthonix Inc

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Combi-Blocks Inc.

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Ryan Scientific, Inc.

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ProdList: 6439
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View Lastest Price from 1-(6-nitropyridin-3-yl)piperazine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(6-nitropyridin-3-yl)piperazine 775288-71-6
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

Shaanxi Dideu Medichem Co. Ltd

Product: 1-(6-Nitropyridin-3-yl)piperazine 775288-71-6
Price: US $0.00-0.00/KG
Min. Order: 100g
Purity: 99%+
Supply Ability: 10 tons
Release date: 2019-12-27

Career Henan Chemical Co

Product: 1-(6-nitropyridin-3-yl)piperazine 775288-71-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1lg; 2kg; 5kg; 10kg; 100kg
Release date: 2019-08-31

775288-71-6, 1-(6-nitropyridin-3-yl)piperazineRelated Search:

tert-butyl 4-(4-aminopyridin-2-yl)piperazine-1-carboxylate 4-(5-AMINOPYRIDIN-2-YL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine 4-(3-NITRO-PYRIDIN-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Palbociclib Impurity 61 1-Piperazinecarboxylic acid, 4-(4-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester INDEX NAME NOT YET ASSIGNED 1-BOC-4-(5-NITRO-2-PYRIDYL)PIPERAZINE 2324831-15-2 1-Piperazinecarboxylic acid, 4-(2-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester 5-(piperazin-1-yl)pyridin-2-aMine Palbociclib Impurity V tert-butyl 4-(3-nitropyridin-4-yl)piperazine-1-carboxylate 4-(6-Amino-pyridin-2-yl)-piperazine-1-carboxylic acid tert-butyl ester 1-BOC-4-(3-AMINO-4-PYRIDINYL)-PIPERAZINE 1-(6-AMino-2,3-diMethoxy-phenyl)-ethanone Palbociclib Impurity 59 1-(3-Pyridinyl)piperazine

1-(6-nitropyridin-3-yl)piperazine

AKOS BBV-002250

OTAVA-BB 1314167

Piperazine, 1-(6-nitro-3-pyridinyl)-

1-(6-Nitro-3-pyridyl)piperazine

1-(6-Nitro-3-pyridinyl)piperazine

Xylulose Impurity 4

1-(6-Nitropyridin-3-yl)piperazin

775288-71-6

palbo