6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline

Product Name: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline
CAS No.: 675576-26-8
Chemical Name: 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline
Synonyms: Isoquinoline-6-boronic acid picol ester;Isoquinoline-6-boronic acid pinacol ester;6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline;Isoquinoline, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOQUINOLINE 97%;6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline (>85%)
CBNumber: CB21562091
Molecular Formula: C15H18BNO2
Formula Weight: 255.12
MOL File: 675576-26-8.mol

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6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Property

Melting point:: 179-184°C
Boiling point:: 397.5±15.0 °C(Predicted)
Density: 1.10±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: solid
pka: 5.03±0.14(Predicted)
Appearance: Off-white to light yellow Solid
InChI: 1S/C15H18BNO2/c1-14(2)15(3,4)19-16(18-14)13-6-5-12-10-17-8-7-11(12)9-13/h5-10H,1-4H3
InChIKey: LFALMDZWCMSBFO-UHFFFAOYSA-N
SMILES: CC1(C)OB(OC1(C)C)c2ccc3cnccc3c2

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26
WGK Germany: 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 766097
Product name: Isoquinoline-6-boronic acid pinacol ester
Purity: 95%
Packaging: 1g
Price: $297
Updated: 2025/07/31

Sigma-Aldrich

Product number: 766097
Product name: Isoquinoline-6-boronic acid pinacol ester
Purity: 95%
Packaging: 5g
Price: $1160
Updated: 2023/01/07

Matrix Scientific

Product number: 120638
Product name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline
Purity: 97%
Packaging: 5g
Price: $1149
Updated: 2021/12/16

Matrix Scientific

Product number: 120638
Product name: 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline
Purity: 97%
Packaging: 10g
Price: $1980
Updated: 2021/12/16

J&W Pharmlab

Product number: 32R0201P
Product name: Isoquinoline-6-boronic acid pinacol ester
Purity: 97%
Packaging: 1g
Price: $148
Updated: 2021/12/16

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6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Chemical Properties,Usage,Production

Uses

Useful boron compound for Suzuki coupling.

Synthesis

A mixture of 6-bromoisoquinoline (208 mg, 1 mmol), bis(pinacolato)diboronate (279 mg, 1.1 mmol), KOAc (323 mg, 3.3 mmol) and Pd(dppf)2Cl2 (73 mg, 0.1 mmol) in DMSO (3 mL) was heated in microwave at 160 ??C for 10 minutes. The mixture was diluted with water (20 mL) and extracted with EtOAc (4x 20 mL). The combined EtOAc was washed with water (15 mL) and brine (15 mL) and dried (Na2SO4). The solvent was removed to give isoquinoline-6-boronic acid pinacol ester.

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Preparation Products And Raw materials

Raw materials

Preparation Products

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6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline Suppliers

China 40 Switzerland 1 United Kingdom 1 United States 3 Global 45

Capot Chemical Co., Ltd

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Sigma-Aldrich

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675576-26-8, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinolineRelated Search:

Isothiazolo[5,4-b]pyridin-6-amine ISOQUINOLINE-3-CARBOXYLIC ACID ISOQUINOLINE-5-CARBOXYLIC ACID C-ISOQUINOLIN-4-YL-METHYLAMINE 8-isoquinolinyl-boronic acid Isoquinoline-3-carboxylic acid ISOQUINOLIN-3-AMINE Isoquinoline-1-carboxylic acid ethyl ester Isoquinoline-4-carbaldehyde METHYL 4-ISOQUINOLINECARBOXYLATE 6-Isoquinolinecarboxaldehyde (9CI)

6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline

Isoquinoline-6-boronic acid pinacol ester

6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ISOQUINOLINE 97%

Isoquinoline-6-boronic acid picol ester

Isoquinoline, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)isoquinoline (>85%)

675576-26-8