piperlonguminine

Product Name: piperlonguminine
CAS No.: 5950-12-9
Chemical Name: piperlonguminine
Synonyms: MEXE;mexedrone;Piperlonguminin;Piperlonguminine;N-Isobutylpiperamide;Mexedrone MEXE MDPHP BK-2CB;Mexedrone Cas no.: 5950-12-9 White crystal 99%;5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide;(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-isobutyl-penta-2,4-dienamide;5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-2E,4E-pentadienamide
CBNumber: CB21562460
Molecular Formula: C16H19NO3
Formula Weight: 273.33
MOL File: 5950-12-9.mol

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piperlonguminine Property

Melting point:: l66-8°C
storage temp.: Store at -20°C
solubility: ≤3mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
form: crystalline solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 9001155
Product name: Piperlonguminine
Purity: ≥98%
Packaging: 5mg
Price: $48
Updated: 2024/03/01

Cayman Chemical

Product number: 9001155
Product name: Piperlonguminine
Purity: ≥98%
Packaging: 10mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 9001155
Product name: Piperlonguminine
Purity: ≥98%
Packaging: 25mg
Price: $117
Updated: 2024/03/01

Cayman Chemical

Product number: 9001155
Product name: Piperlonguminine
Purity: ≥98%
Packaging: 50mg
Price: $210
Updated: 2024/03/01

ApexBio Technology

Product number: C3508
Product name: Piperlonguminine
Packaging: 50mg
Price: $222
Updated: 2021/12/16

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piperlonguminine Chemical Properties,Usage,Production

Description

This amide alkaloid also occurs in the roots of Piper longum and yields colourless needles from EtOH. The ultraviolet spectrum exhibits absorption maxima at 245,256, 307 and 340 mil. The side chain is doubly unsaturated and on catalytic hydrogenation, the base furnishes the tetrahydro derivative, m.p. 66°C.

Description

Piperlonguminine is an alkaloid amide from species of the genus Piper, a plant used in traditional medicine that demonstrates antifungal, anticancer, antihyperlipidemic, and anti-inflammatory properties. Piperlonguminine (3-12.5 μM) has been shown to dose dependently decrease expression of amyloid precursor protein and amyloid-β peptide in human neuroblastoma cells, suggesting it may have implication in treating Alzheimer’s disease.

Definition

ChEBI: (E,E)-Piperlonguminine is a member of benzodioxoles.

in vitro

in a previous study, piperlonguminine was discovered to inhibit melanin production in melanoma b16 cells stimulated with α-msh, 3-isobutyl-1-methylxanthine or protoporphyrin ix, where piperlonguminine showed stronger depigmenting efficacy. however, piperlonguminine could not alter1-oleoyl-2-acetyl-sn-glycerol-induced melanogenesis and could not affect protein kinase c-mediated melanin production. in additioin, piperlonguminine was not able to inhibit the catalytic activity of cell-free tyrosinase from melanoma b16 cells, and such effect was attributed to the inhibitory action of piperlonguminine on α-msh-induced signaling via camp to the camp responsive element binding protein [1].

in vivo

in vivo, rats were subjected to middle cerebral artery occlusion for 1h, followed by reperfusion for 23 h. the results showed that the intraperitoneal injection of piperlonguminine pe at 2.4 mg/kg was able to produce a significant neuroprotective potential in rats with cerebral ischemia. in addition, piperlonguminine could attenuate the neurological deficit scores, brain infarct volume and brain water content, and could inhibit the activation of nf-κb and mapk [2].

References

Chatterjee, Dutta., Tetrahedron Lett., 1797 (1966)
Chatterjee, Dutta., Tetrahedron, 23, 1769 (1967)

piperlonguminine Preparation Products And Raw materials

Raw materials

Preparation Products

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piperlonguminine Suppliers

China 62 India 1 United States 7 USA 1 Global 71

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@163.com
Country: China
ProdList: 284
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Shanghai Winherb Medical Technology Co., Ltd.

Tel: 400-1865138 13341702378
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Cheng Du Pufeide Biotechnology Co., Ltd.

Tel: 028-82610909 13388174823
Fax: 8171-1798
Email: scglp@glp-china.com
Country: China
ProdList: 1064
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Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9353
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15185
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Hangzhou Zhenghan Biological Technology Co., Ltd.

Tel: +8618968058020
Fax: 0571-88781753
Email: zhenghanbio@qq.com
Country: China
ProdList: 28
Advantage: 56

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
Fax: +86-27-84254680
Email: aileen@chemfaces.com
Country: China
ProdList: 7059
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Shanghai Yihe Biological Technology Co., Ltd.

Tel: 17721395025
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Email: 2423903095@qq.com
Country: China
ProdList: 3149
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Chengdu Push Bio-Technology Co., Ltd.

Tel: 028-85370565-229 18080489829
Email: 3004654993@qq.com
Country: China
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Henan Alfachem Co.,Ltd.

Tel: 0371-0371-55051623 18137891487
Fax: QQ：2853979817
Email: 2853979817@qq.com
Country: China
ProdList: 9959
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View Lastest Price from piperlonguminine manufacturers

Wuhan Boyuan Import & Export Co., LTD

Product: Piperlonguminine 5950-12-9
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000tons
Release date: 2023-07-14

Henan Bao Enluo International TradeCo.，LTD

Product: piperlonguminine 5950-12-9
Price: US $100.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000tons
Release date: 2023-06-19

Weijer International Trade (Hebei) Co., Ltd

Product: Piperlonguminine 5950-12-9
Price: US $170.00/KG
Min. Order: 1KG
Purity: >99%
Supply Ability: 50000kg/Month
Release date: 2023-03-14

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MEXE

Mexedrone MEXE MDPHP BK-2CB

Mexedrone Cas no.: 5950-12-9 White crystal 99%

Mexedrone Crystal , mexe Pharmaceutical Intermediates CAS 5950-12-9

5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide

Piperlonguminine

5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-2E,4E-pentadienamide

mexedrone

N-Isobutylpiperamide

(2E,4E)-5-(1,3-benzodioxol-5-yl)-N-isobutyl-penta-2,4-dienamide

2,4-Pentadienamide, 5-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (2E,4E)-

TIANFU-CHEM CAS:5950-12-9 5-benzo[1,3]dioxol-5-yl-N-(2-methylpropyl)penta-2,4-dienamide

Piperlonguminin

amide,Inhibitor,inhibit,alkaloid,anti-melanogenic,Bacterial,antibacterial,neuroprotective,antifungal,Piperlonguminine,anti-platelet,Fungal,antitumor,anti-inflammatory,Piper

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-N-isobutylpenta-2,4-dienamide

5950-12-9

5650-12-9

for pharmaceutical intermediate