(R)-1-Boc-3-(hyroxymethyl)piperidine

Product Name: (R)-1-Boc-3-(hyroxymethyl)piperidine
CAS No.: 140695-85-8
Chemical Name: (R)-1-Boc-3-(hyroxymethyl)piperidine
Synonyms: tube1045;BOC-R-PIP-3MEOH;N-BOC-(3R)-PIP(3-CH2OH);(R)-N-Boc-3-piperidinemethanol;3-(R)-N-BOC-PIPERIDINE METHANOL;(R)-N-Boc-piperdine-3-hydroxymethyl;(R)-N-BOC-3-HYDROXYMETHYL PIPERIDINE;(R)-1-BOC-3-(HYROXYMETHYL)PIPERIDINE;(R)-N-Boc-3-(hyroxymethyl)piperidine;(R)-1-BOC-3-(HYDROXYMETHYL)PIPERIDINE
CBNumber: CB2157300
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 140695-85-8.mol

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(R)-1-Boc-3-(hyroxymethyl)piperidine Property

Melting point:: 77-81 °C
Boiling point:: 308.0±15.0 °C(Predicted)
Density: 1.059±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.93±0.10(Predicted)
form: Powder
color: White to yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-5-9(7-12)8-13/h9,13H,4-8H2,1-3H3/t9-/m1/s1
InChIKey: OJCLHERKFHHUTB-SECBINFHSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC[C@@H](CO)C1
CAS DataBase Reference: 140695-85-8(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N,T
Risk Statements: 25-36-50
Safety Statements: 26-45-61
RIDADR: UN2811
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B656698
Product name: (R)-1-Boc-3-(Hydroxymethyl)piperidine
Packaging: 2.5g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: OR15673
Product name: (3R)-3-(Hydroxymethyl)piperidine,N-BOCprotected
Purity: 97%
Packaging: 1g
Price: $27
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-J2
Product name: (3R)-3-(Hydroxymethyl)piperidine, N-Boc protected
Packaging: 1g
Price: $29
Updated: 2021/12/16

Activate Scientific

Product number: AS40022
Product name: (R)-1-Boc-3-(hydroxymethyl)piperidine
Purity: 97% ee
Packaging: 1g
Price: $35
Updated: 2021/12/16

Synthonix

Product number: H12318
Product name: (R)-1-Boc-3-(hydroxymethyl)piperidine
Purity: 95+%
Packaging: 1g
Price: $60
Updated: 2021/12/16

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(R)-1-Boc-3-(hyroxymethyl)piperidine Chemical Properties,Usage,Production

Uses

(R)-(-)-1-Boc-3-(hydroxymethyl)piperidine is used as pharmaceutical intermediate.

Synthesis

163438-09-3

116574-71-1

The general procedure for the synthesis of tert-butyl 3-(hydroxymethyl)piperidine-1-carboxylate from (R)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid is as follows: Example 58: Synthesis of N-(2-methylpropyl)-N-(3,5-dichlorophenyl)methyl-(3R)-piperidin-3-ylmethylamine 1.5L-tartrate: (i) Borane-tetrahydrofuran complex (1 M solution of THF, 65.4 mL, 65.4 mmol, 3 eq.) was slowly added dropwise to a solution of (R)-(-)-N-Boc-piperidinic acid (5 g, 21.8 mmol, 1 eq.) in THF (50 mL) at room temperature. The reaction mixture was stirred at room temperature for 16 hours. Subsequently, the solution was cooled to 0 °C and hydrolyzed by careful addition of 2N aqueous sodium hydroxide solution (250 mL). After hydrolysis, the mixture was heated and kept for 48 hours. After completion of the reaction, the mixture was again cooled to 0 °C and extracted with ether (3 x 100 mL). The organic layers were combined, washed with brine (100 mL), dried over magnesium sulfate, filtered and concentrated in vacuum. The residue was purified by fast chromatography using an isohexane solution of 50-70% ethyl acetate as eluent to afford tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate (4.56 g, 98% yield). 1H NMR (300 MHz, CDCl3) δ: 4.0-2.7 (6H, br m), 2.17-1.19 (5H, br m), 1.46 (9H, s).

References

[1] Patent: WO2005/118531, 2005, A1. Location in patent: Page/Page column 74
[2] Patent: WO2006/12308, 2006, A1. Location in patent: Page/Page column 68
[3] Patent: WO2017/103611, 2017, A1. Location in patent: Paragraph 00298

(R)-1-Boc-3-(hyroxymethyl)piperidine Preparation Products And Raw materials

Raw materials

Ethanol Acetone Calcium chloride D-(-)-Tartaric Acid Di-tert-butyl dicarbonate Sodium borohydride Tetrahydrofuran Lithium Aluminum Hydride Ethyl nipecotate

Preparation Products

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View Lastest Price from (R)-1-Boc-3-(hyroxymethyl)piperidine manufacturers

Career Henan Chemical Co

Product: (R)-1-Boc-3-(hyroxymethyl)piperidine 140695-85-8
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-19

140695-85-8, (R)-1-Boc-3-(hyroxymethyl)piperidineRelated Search:

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140695-85-8

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