3-Bromo-2,6-dimethylpyridine

Uses

Product Name: 3-Bromo-2,6-dimethylpyridine
CAS No.: 3430-31-7
Chemical Name: 3-Bromo-2,6-dimethylpyridine
Synonyms: 6-dimethylpyridine;3-Bromo-2,6-dimethyl;3-Bromo-6-methyl-2-picolin;3-Bromo-6-methyl-2-picoline;2,6-Dimethyl-3-bromopyridine;3-BROMO-2,6-DIMETHYLPYRIDINE;Pyridine, 3-bromo-2,6-dimethyl-;3-Bromo-2,6-dimethylpyridine 98%;3-Bromo-2,6-dimethylpyridine ,97%;2,6-Dimethylpyridine-3-Bromopyridine
CBNumber: CB2161200
Molecular Formula: C7H8BrN
Formula Weight: 186.05
MOL File: 3430-31-7.mol

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3-Bromo-2,6-dimethylpyridine Property

Boiling point:: 56-58°C 2mm
Density: 1.431 g/mL at 25 °C
refractive index: n20/D1.552
Flash point:: 86℃
storage temp.: Inert atmosphere,Room Temperature
form: liquid
pka: 4.32±0.10(Predicted)
color: Clear, colourless
InChI: InChI=1S/C7H8BrN/c1-5-3-4-7(8)6(2)9-5/h3-4H,1-2H3
InChIKey: TUJVGHCSNXCAFE-UHFFFAOYSA-N
SMILES: C1(C)=NC(C)=CC=C1Br
CAS DataBase Reference: 3430-31-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39-36/39
RIDADR: UN1760
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 734799
Product name: 3-Bromo-2,6-dimethylpyridine
Purity: 97%
Packaging: 5g
Price: $94.1
Updated: 2025/07/31

TRC

Product number: B691763
Product name: 3-Bromo-2,6-dimethylpyridine
Packaging: 250mg
Price: $55
Updated: 2021/12/16

Apolloscientific

Product number: OR6452
Product name: 3-Bromo-2,6-dimethylpyridine
Purity: 98%
Packaging: 5g
Price: $38
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-9-H2
Product name: 3-Bromo-2,6-dimethylpyridine
Purity: 98%
Packaging: 5G
Price: $42
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB55319
Product name: 3-Bromo-2,6-lutidine
Packaging: 2g
Price: $50
Updated: 2021/12/16

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3-Bromo-2,6-dimethylpyridine Chemical Properties,Usage,Production

Uses

2,6-Dimethyl-3-bromopyridine is an important organic synthesis intermediate with wide applications in pharmaceuticals and pesticides. For example, it can be used to synthesize a new generation of quinolone antibacterial drug—balofloxacin.

Synthesis

108-48-5

3430-31-7

General procedure for the synthesis of 2,6-dimethyl-3-bromopyridine from 2,6-dimethylpyridine: 2,6-dimethylpyridine (115 kg, 1073.3 mol) was slowly added to pre-cooled fuming sulphuric acid (20-23%, 1015 kg, 2276.7 mol) over a period of 4.5 h at 0 °C, and the reaction temperature was maintained below 14 °C. The reaction temperature was kept below 14 °C. Subsequently, bromine (88.18 kg, 1103.6 mol) was added dropwise over 1 h at 5-10 °C. The reaction mixture was slowly warmed up to 150 °C over 12 hours. Analysis by TLC showed that about 40-50% of the feedstock was converted to the target product, while about 5% of the dimer by-product was generated. After cooling the reaction mixture to room temperature, bromine (88.18 kg, 1103.6 mol) was again added slowly. The reaction mixture was slowly heated to 65-75 °C over a period of 15 h. TLC analysis showed that the product conversion increased to 65-70% and the dimer by-product generation was maintained at 5%. The reaction mixture was quenched by the addition of water (500 L) and the reaction temperature was controlled below 20 °C during quenching. Subsequently, the reaction mixture was alkalized with 6.6 M NaOH solution (3800 L) and the temperature was controlled below 40 °C during alkalization. Ethyl acetate (220 L) was added and the mixture was stirred for 1 hour and then left to stand for 2 hours. The organic and aqueous layers were separated and the aqueous layer was treated with a solution of NaOH (10 kg) in water (10 L) and then extracted with ethyl acetate (160 L). The organic extracts were combined, washed with brine (100 L), dried with anhydrous sodium sulfate (50.0 kg), filtered and the solvent evaporated at atmospheric pressure. The residue was subjected to vacuum distillation and the fractions were collected at 58-60 °C and 2 mmHg to give 2,6-dimethyl-3-bromopyridine (98.45 kg, 49.2% yield) as a colorless liquid.

References

[1] Bioorganic Chemistry, 2004, vol. 32, # 1, p. 13 - 25
[2] Patent: WO2016/29216, 2016, A2. Location in patent: Page/Page column 83
[3] Patent: WO2018/81513, 2018, A1. Location in patent: Page/Page column 64
[4] Angewandte Chemie - International Edition, 2016, vol. 55, # 44, p. 13744 - 13748
[5] Angew. Chem., 2016, vol. 128, p. 13948 - 13952,5

3-Bromo-2,6-dimethylpyridine Preparation Products And Raw materials

Raw materials

FUMING SULFURIC ACID 2,6-Lutidine Ethyl acetate Bromine Sodium hydroxide

Preparation Products

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3-Bromo-2,6-dimethylpyridine Suppliers

China 204 Germany 5 India 9 The Netherlands 1 United Kingdom 5 United States 19 Global 243

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View Lastest Price from 3-Bromo-2,6-dimethylpyridine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 3-Bromo-2,6-dimethylpyridine 3430-31-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Dideu Industries Group Limited

Product: 3-Bromo-2,6-dimethylpyridine 3430-31-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-08-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 3-Bromo-2,6-dimethylpyridine 3430-31-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

3430-31-7, 3-Bromo-2,6-dimethylpyridineRelated Search:

3,5-DIBROMO-2,4,6-TRIMETHYLPYRIDINE 2-BROMO-4,6-DIMETHYLPYRIDINE 3-Bromo-2,4,6-trimethylpyridine BIS(2,4,6-TRIMETHYLPYRIDINE)BROMONIUM HEXAFLUOROPHOSPHATE 3-Bromo-2,6-dimethylpyridine 2,6-Dimethyl-3,5-dibromopyridine 3-AMINO-2-BROMO-4,6-DIMETHYLPYRIDINE,5-Amino-2-bromo-4,6-dimethylpyridine 2-AMINO-3-BROMO-5,6-DIMETHYLPYRIDINE 4-Bromo-2,6-dimethylpyridine 2-AMINO-5-BROMO-3,4-DIMETHYLPYRIDINE 97%,2-AMINO-5-BROMO-3,4-DIMETHYLPYRIDINE 3-Bromo-2,5-dimethylpyridine Dimethyl 5-bromopyridine-2,3-dicarboxylate 6-Amino-2,4-dimethyl-3-bromopyridine 3-BROMO-2,4-DIMETHYLPYRIDINE 2,6-Lutidine 5-BROMO-6-CYANOPYRIDINE-2-CARBOXYLIC ACID 3,4-DIBROMO-2,6-DIMETHYLPYRIDINE 3-Bromopyridine-2,6-dicarboxylic acid

3-BROMO-2,6-DIMETHYLPYRIDINE

3-Bromo-2,6-dimethylpyridine 98%

2,6-Dimethylpyridine-3-Bromopyridine

2,6-Dimethyl-3-bromopyridine

3-Bromo-6-methyl-2-picoline

3-Bromo-2,6-dimethylpyridine ,97%

3-Bromo-2,6-dimethyl

3-BroMo-2,6-diMethylpyridine 98%, 6-diMethylpyridine 98%

3-Bromo-6-methyl-2-picolin

Pyridine, 3-bromo-2,6-dimethyl-

6-Chloro-4-methyl-4-pyridinecarboxylic acid

3-Bromo-2,6-dimethylpyridine ISO 9001：2015 REACH

6-dimethylpyridine

3-Bromo-2,6-dimethylpyridine CAS NO.3430-31-7

3430-31-7

Pyridine

Heterocycle-Pyridine series

Pyridine Series