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2',6'-DIMETHYLACETANILIDE

Product Name
2',6'-DIMETHYLACETANILIDE
CAS No.
2198-53-0
Chemical Name
2',6'-DIMETHYLACETANILIDE
Synonyms
NSC 54130;2,6-Acetoxylide;2’,6’-Acetoxylidid;LIDOCAINE EP IMP C;2',6'-ACETOXYLIDIDE;TIMTEC-BB SBB008144;Lidocaine Impurity 7;N-ACETYL-2,6-XYLIDINE;N-Acetyl-2,6-xylidene;2,6-DIMETHYLACETANILIDE
CBNumber
CB2161927
Molecular Formula
C10H13NO
Formula Weight
163.22
MOL File
2198-53-0.mol
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2',6'-DIMETHYLACETANILIDE Property

Melting point:
182-184 °C(lit.)
Boiling point:
290.31°C (rough estimate)
Density 
1.052
refractive index 
1.5400 (estimate)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
15.14±0.70(Predicted)
color 
Crystals
CAS DataBase Reference
2198-53-0(CAS DataBase Reference)
EPA Substance Registry System
Acetamide, N-(2,6-dimethylphenyl)- (2198-53-0)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36
WGK Germany 
3
RTECS 
AN7470000
TSCA 
Yes
HS Code 
29242990
Toxicity
LD50 orl-mus: 620 mg/kg TXAPA9 19,20,71
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
126357
Product name
2′,6′-Dimethylacetanilide
Purity
97%
Packaging
25g
Price
$89.8
Updated
2023/06/20
Sigma-Aldrich
Product number
PHR1671
Product name
2′,6′-Dimethylacetanilide (Lidocaine RCC)
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
100mg
Price
$544
Updated
2022/05/15
Alfa Aesar
Product number
B25687
Product name
2',6'-Dimethylacetanilide, 97%
Packaging
25g
Price
$33.65
Updated
2024/03/01
Alfa Aesar
Product number
B25687
Product name
2',6'-Dimethylacetanilide, 97%
Packaging
100g
Price
$87.65
Updated
2024/03/01
TRC
Product number
D446680
Product name
N-(2,6-Dimethylphenyl)acetamide
Packaging
50g
Price
$165
Updated
2021/12/16
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2',6'-DIMETHYLACETANILIDE Chemical Properties,Usage,Production

Chemical Properties

off-white to yellow cryst. needles or cryst.powder

Uses

Lidocaine (L397800) impurity.

Synthesis Reference(s)

Journal of the American Chemical Society, 106, p. 5759, 1984 DOI: 10.1021/ja00331a073
Chemical and Pharmaceutical Bulletin, 30, p. 4242, 1982 DOI: 10.1248/cpb.30.4242
Journal of Heterocyclic Chemistry, 2, p. 181, 1965 DOI: 10.1002/jhet.5570020214

General Description

2,6-Dimethylacetanilide undergoes iodination by electrophylic substitution reaction of chloroacetanilide, in the presence of ferroiodide and copperchloride as catalyst, to form 4-iodine-2,6-dimethylacetanilide.

Safety Profile

Moderately toxic by ingestion.When heated to decomposition it emits toxic fumes ofNOx.

2',6'-DIMETHYLACETANILIDE Preparation Products And Raw materials

Raw materials

Ammonium hydroxide Ethanol Acetic anhydride Acetic acid 2,6-Dimethylaniline Pyridine

Preparation Products

2,4,6-TRIHYDROXY-1,3-DIMETHYL BENZENE
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2',6'-DIMETHYLACETANILIDE Suppliers

Belgium 2 Canada 1 China 125 Europe 1 France 1 Germany 7 India 17 Japan 3 Slovakia 1 South Korea 1 Sweden 1 Switzerland 5 The Netherlands 1 United Kingdom 7 United States 21 USA 1 Global 195
Matrix Fine Chemicals GmbH
Tel
--
Fax
--
Email
nfo@matrix-fine-chemicals.com
Country
Switzerland
ProdList
6968
Advantage
58
Achemica
Tel
--
Fax
--
Email
contact@achemica.com
Country
Switzerland
ProdList
6155
Advantage
50
Biosynth AG
Tel
--
Fax
--
Email
welcome@biosynth.ch
Country
Switzerland
ProdList
3324
Advantage
72
SIGMA-RBI
Tel
--
Fax
--
Country
Switzerland
ProdList
6896
Advantage
91
DOTTIKON EXCLUSIVE SYNTHESIS AG
Tel
--
Fax
--
Email
info@dottikon.com
Country
Switzerland
ProdList
274
Advantage
68
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View Lastest Price from 2',6'-DIMETHYLACETANILIDE manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Lidocaine EP Impurity C 2198-53-0
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
0.98
Supply Ability
10g
Release date
2024-05-21
Career Henan Chemical Co
Product
2',6'-DIMETHYLACETANILIDE 2198-53-0
Price
US $3.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2020-01-30

2198-53-0, 2',6'-DIMETHYLACETANILIDERelated Search:

2',6'-DIMETHYLACETANILIDE 2-Chloro-N-(2,6-dimethylphenyl)acetamide Lidocaine 2,4-DIMETHYLACETANILIDE,2',4'-DIMETHYLACETANILIDE 3,4-DIMETHYLACETANILIDE 98+%,3',4'-DIMETHYLACETANILIDE,3,4-DIMETHYLACETANILIDE Ranolazine α-Chloro-N-(2-methoxyethyl)-2',6'-dimethylacetanilide N-(2,5-diMethylphenyl)acetaMide 2-Acetyl-2',4'-dimethylacetanilide 2-chloro-N-(3-methoxy-2-thienyl-2′,6′-dimethylacetanilide A-(DIETHYLAMINO)-2 6-DIMETHYLACETANILIDE HYDROCHLORIDE 2-Bromo-2',6'-dimethylacetanilide 1-(2,6-DIMETHYL-PHENYL)-PYRROLE-2,5-DIONE 6-BROMO-4-METHYL-1-PHENYLANTHRAPYRIDONE AURORA 10634 N-(2,6-dimethylphenyl)-3-oxobutanamide TIMTEC-BB SBB005915 4-[(2,6-DIMETHYLPHENYL)AMINO]-4-OXOBUTANOIC ACID

  • N-ACETYL-2,6-XYLIDINE
  • N-(2,6-DIMETHYL-PHENYL)-ACETAMIDE
  • TIMTEC-BB SBB008144
  • ALPHA,2',6'-DIMETHYLACETANILIDE
  • 2',6'-DIMETHYLACETANILIDE
  • 2,6-DIMETHYLACETANILIDE
  • 2',6'-ACETOXYLIDIDE
  • 2,6-Acetoxylide
  • 2’,6’-Acetoxylidid
  • 2’,6’-dimethyl-acetanilid
  • Acetamide,N-(2,6-dimethylphenyl)-
  • Acetanilide, 2',6'-dimethyl-
  • n-(2,6-dimethylphenyl)-acetamid
  • N-Acetyl-2,6-dimethylanilin
  • N-Acetyl-2,6-dimethylaniline
  • 2',6'-Dimethylacetanilide ,99%
  • 2',6'-Dimethylacetanilide,97%
  • 2',6'-Dimethylacetanilide2',6'-Acetoxylidide
  • Lidocaine Impurity C(EP)
  • Lidocaine Impurity 5(Lidocaine EP Impurity C)
  • NSC 54130
  • 2′,6′-Dimethylacetanilide (Lidocaine RCC)
  • Lidocaine EP Impurity C
  • Lidocaine Impurity 7
  • Lidocaine Related Compound C
  • Lidocaine BP Impurity C
  • 2',6'-dimethylacetylaniline
  • Quinuclidinyl Benzylate
  • Lidocaine hydrochloride impurity892
  • Lidocaine Hydrochloride Impurity C
  • Lidocaine Hydrochloride EP Impurity C
  • Lidocaine EP Impurity 3
  • Lidocaine EP Impurity C N (2,6-Dimethylphenyl)acetamide
  • N-Acetyl-2,6-xylidene
  • 2',6'-DIMETHYLACETANILIDE
  • LIDOCAINE EP IMP C
  • 2198-53-0
  • CH32C6H3NHCOCH3
  • Amides
  • Building Blocks
  • Carbonyl Compounds
  • Organic Building Blocks
  • Anilines, Amides & Amines
  • Amines
  • Aromatics
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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