Triptolide

Tripterygium wilfordii Anti-inflammatory and immunosuppressive effects Anti-cancer effects Using TLCS method to determine the content of triptolide

Product Name: Triptolide
CAS No.: 38748-32-2
Chemical Name: Triptolide
Synonyms: (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one;PG490;Triptolide 38748-32-2;Thunder God Vine Extract;8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-,(3bs,4as,5as,6r,6ar;triptolid;riptolide;TRIPTOLIDE;NSC 163062;TRIPTOLIDE95%
CBNumber: CB2167404
Molecular Formula: C20H24O6
Formula Weight: 360.4
MOL File: 38748-32-2.mol

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Triptolide Property

Melting point:: 226-227°C
Boiling point:: 412.43°C (rough estimate)
alpha: D25 -154°
Density: 1.1656 (rough estimate)
refractive index: 1.4450 (estimate)
storage temp.: 2-8°C
solubility: DMSO: soluble
pka: 14.25±0.60(Predicted)
form: solid
color: white to off-white
Merck: 14,9747
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey: DFBIRQPKNDILPW-CIVMWXNOSA-N
CAS DataBase Reference: 38748-32-2(CAS DataBase Reference)
EPA Substance Registry System: Trisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)- (38748-32-2)

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Safety

Safety Statements: 22-24/25
RIDADR: 2811
WGK Germany: 3
RTECS: YK7751000
HazardClass: 6.1
PackingGroup: I
HS Code: 29321900
Toxicity: LD50 i.p. in mice: 1.93 mg/kg (Chen)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 645900
Product name: Triptolide
Purity: A novel diterpene triepoxide isolated from the Chinese herb
Packaging: 1mg
Price: $142
Updated: 2024/03/01

Sigma-Aldrich

Product number: 645900
Product name: Triptolide
Purity: A novel diterpene triepoxide isolated from the Chinese herb
Packaging: 5mg
Price: $560
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89811
Product name: Triptolide
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $556
Updated: 2023/06/20

TCI Chemical

Product number: T2899
Product name: Triptolide
Purity: >98.0%(HPLC)
Packaging: 10mg
Price: $379
Updated: 2024/03/01

Cayman Chemical

Product number: 11973
Product name: Triptolide
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

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Triptolide Chemical Properties,Usage,Production

Tripterygium wilfordii

There are four species under the genus Tripterygium in the world, and all are native to China, with three species being medicine. Tripterygium wilfordii is a woody climber, 2-3 meters high. Branchlets are reddish and with brown angular, with oblong tuberculate projections and iron brown hairs. Flowering period is from May to June. Fruit ripening period is from August to September. It grows in shady and humid slopes, valleys, bushes besides streams and secondary miscellaneous forests, with the distribution in the south of the Yangtze River, Anhui, Zhejiang, Fujian, Taiwan, Jiangxi, Hunan, Guangdong and even the southwest provinces. It is harvested in summer or autumn. It is bitter and poisonous, and can be used as insecticide, anti-inflammatory and detoxification. This product is poisonous, thus be careful when orally taking in.
1.Treatment of rheumatoid arthritis: smash the roots and leaves of Tripterygium wilfordii and apply it externally. Remove it half an hour later, otherwise blister could occur. (Jiangxi, " Handbook of Herbs").
2. Treatment of skin itchiness: smash the leaves of Tripterygium wilfordii and apply it ( "Medicinal Flora in Hunan").
3. Treatment of snake strand sore: grind the flowers of Tripterygium wilfordii and the root of three-nerved spicebush, and apply it the affected area (“ Medicinal Flora in Hunan ").

Anti-inflammatory and immunosuppressive effects

Triptolide is an epoxy diterpene lactone compound that extracted from the roots, leaves, flowers and fruits of Tripterygium wilfordii (Celastraceae). Triptolide, with alkaloids like wilfordine, wilforine, wilforgine, Wilfortrine, wilfozine and Wilfornine, constitutes the main active ingredient of Tripterygium extraction. It is insoluble in water, soluble in methanol, dimethyl sulfoxide, ethanol, ethyl acetate, chloroform ect. It has anti-inflammatory and immunosuppressive effects: with the application of 10μg/kg sc Triptolide in continuous 10 days, the croton oil-induced ear edema in mice can be reduced. The in vitro tests with the application of 0.05~1μg/ml Triptolide in continuous 7 days showed this product has a stabilizing effect on sheep erythrocyte membrane; with the application of 75,150mg/kgsc Triptolide in continuous 7 days, the total complement levels of rat serum significantly increased, and the formation of hemolysin antibody in primary immune response was significantly inhibited, but no significant inhibition was found in the formation of hemolysin antibody in the second immune response; with the application of 150μg/kg ig Triptolide in continuous 7 days, a certain degree of inhibition in mouse peritoneal phagocytic function; with the application of 300μg/kg sc Triptolide in continuous 15 days, the croton oil-induced ear edema in mice was inhibited; with the application of 75,150μg/kgsc Triptolide in continuous 14 days, the carrageenan paw swelling in rat was inhibited; with the application of 0.22~4.44μg/ml Triptolide in Polygalatenuifolia extraction, a protective effect on RBCM of rats was showed; with the application of 0.25,1mg/kg ip Triptolide, antibody production and secretion in mice were inhibited (QHS method); with the application of 50,500ng/ml concentration, proliferative responses of T cell and B cell were significantly inhibited; with the application of 5,50,500ng/ml Triptolide in vitro and 0.5,0.75,1mg/kg ip drug in vivo, the production of mouse spleen cells IL-2 was significantly inhibited; with the application of 0.1~1μg/ml Triptolide in vitro, Con A-induced lymphocyte growth was inhibited; with the application of 0.5~10μg/L Triptolide the mixed lymphocyte culture (MLC) was inhibited: after 60Co irradiation, the mixed lymphocyte that induced with the concentration of 5,10μg/L Triptolide inhibited the second MLC, showing that triptolide can induce suppression T cells (Ts); with the application of 0.12~0.5mg/kg ip Triptolide, the DNFB-induced DTH in mice was significantly inhibited; with the application of 0.25,0.5mg/kg Triptolide, the secretion activity of mice spleen cells IL-2 was inhibited, and the increased DTH responses that induced by high-dose cyclophosphamide was also inhibited; with the application of 0.25mg/kg Triptolide, mouse thymus Th/Ts cell ratio reduced. Experimental results indicate that triptolide has immunosuppression, and the mechanism may be related to inhibition of Th cells and secretion activity of IL-2 and inducing Ts cells.
The above information is edited by the Chemicalbook of Cheng Jingmin.

Anti-cancer effects

In recent years, a large number of in vitro and in vivo studies demonstrated this product has good anti-tumor activity to a variety of cancers such as leukemia, breast cancer, pancreatic cancer and lung cancer. Recent studies have found that triptolide not only affects certain proteins and signaling pathways specifically, but also inhibits broad gene transcription, but the mechanism remains to be further clarified.
Yu Qiang group in Shanghai Institute of Materia Medica of Chinese Academy of Sciences studied in-depth the molecular mechanisms of Triptolide in suppressing broad gene transcription. The study found that Triptolide inhibited gene transcription by promoting the phosphorylation of the largest and most important functional subunit Rpb1 in RNA polymerase II, and subsequent Rpb1 ubiquitin degradation. PTEF-b, the upstream kinases of Rpb1, plays a positive role in the regulation of phosphorylation process of Rpb1 that induced by Triptolide. The study also found that Triptolide could induce DNA damage. These results indicate that triptolide suppresses broad gene transcription by causing DNA damage in cells and thus activating the P-TEFb, which can phosphorylate Rpb1 and cause Rpb1 degradation.

Using TLCS method to determine the content of triptolide

1. Chromatographic conditions: silica gel G-CMCNa plate; chloroform-ether (2: 1) as developing solvent; 2% 3,5-dinitro-benzoic acid ethanol solution and 2mol/L Sodium hydroxide ethanol solution. Mix them with the ratio 1: 3 before use as the chromogenic agent, spray the mixture and view the results under natural light.
2. The preparation of the reference solution: Weigh appropriate triptolide accurately as the reference substance, and add chloroform to make the reference solution with 1.528mg triptolide per ml.
3. Preparation of sample solution: Weigh appropriate dried herbs accurately, and make reflux extraction three times by adding ethanol, with 3 hours each time. Combine the extraction and recover ethanol to dryness, and then extract triptolide by dissolving in ethyl acetate until no triptolide presence in TLC, and recover ethyl acetate to get the extract. weigh accurately 0.4g extract powder, which has been dried at 90 ℃to constant weight and dissolve it in 5ml of dichloromethane, and mix with 8g neutral alumina, and evaporate the dichloromethane and transferre to a Soxhlet extractor, and reflux for 3h with petroleum ether (60~90 ℃), and discard the petroleum ether and remove the filter cartridge, shake off the solvent, and then reflux for 5h by placing it in an extractor with 70ml chloroform, recover chloroform to dryness and cool it, and dissolve it to precise 3ml chloroform as the sample solution.
4. Determination: precisely drawing 10μl sample solution and 2,7μl reference solution, and point them to the same piece of thin plate. According to the chromatographic conditions to spread, take out, dry and color. Cover it with the same size of glass plate and seal it for four cycles. 10min later, scan it under thin layer scanning. λS = 535nm, λR = 650nm; dual wavelength reflection zigzag scanning; slit: 1.25mm × 1.25mm; sensitivity × 5. Measure the absorption integral value of the sample and reference substance, and calculate the content by two external standard method.
5. Measurement results: Based on the above-mentioned conditions, the content of triptolide in Tripterygium root bark, root center and whole root were 0.001%, 0.0004%, 0.0018%.

Description

Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity.? Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1??Blocks transactivation of NFkB.2?Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50?= 12 nM) and synergizes with other anticancer agents.3?Inhibits the inflammatory response and remarkably decreases production of TNF-a, IL-1b and IL-6 in a rat model of rheumatoid arthritis.4

Chemical Properties

White Crystalline Solid

Uses

Triptolide is a diterpenoid triepoxide with immunosuppressant and antitumor properties.

Uses

Labelled Triptolite (T815600), diterpenoid triepoxide with immunosuppressant and antitumor properties.

Definition

ChEBI: Triptolide is an organic heteroheptacyclic compound, an epoxide, a gamma-lactam and a diterpenoid. It has a role as an antispermatogenic agent and a plant metabolite.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Inhibits cytokine-induced gene expression via inhibition of NF- κ B transcriptional activity. Induces apoptosis in tumor cells by blocking TNF- α mediated c-IAP2 and c-IAP1 (members of the inhibitor of apoptosis family) induction. Immunosuppressive with anti-inflammatory and antitumor activity.

Biochem/physiol Actions

Triptolide is a diterpene triepoxide, the principal active ingredient in extracts from the Chinese herb Tripterygium wilfordii hook (TwHF). It is a potent immunosuppressant and anti-inflammatory. Triptolide has been shown to inhibit the expression of IL-2 in activated T cells at the level of purine-box/nuclear factor and NF-κB mediated transcription activation. It synergizes with cyclosporin A in promoting graft survival in animal models and in suppression of graft versus host disease in allogeneic bone marrow transplants. In addition, it induces apoptosis in tumor cells and potentiates tumor necrosis factor (TNFα) induction of apoptosis in part through the suppression of c-IAP2 and c-IAP1 induction.

storage

Store at -20°C

References

1) He?et al. (2015),?Covalent Modification of a Cysteine Residue in the XPB Subunit of the General Transcription Factor TFIIH Through Single Epoxide Cleavage of the Transcription Inhibitor Triptolide; Angew. Chem. Int. Ed. Eng.?54?1859 2) Lee?et al. (1999),?PG490 (Triptolide) Cooperates with Tumor Necrosis factor-α to Induce Apoptosis in Tumor Cells; J. Biol. Chem,?274?13451 3) Qiao?et al. (2016),?Synergistic antitumor activity of gemcitabine combined with triptolide in pancreatic cancer cells; Oncol. Lett.,?11?3527 4) Fan?et al.?(2016),?Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis; Int. J. Mol. Sci.?17?498

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View Lastest Price from Triptolide manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Triptolide 38748-32-2
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: ≥98%
Supply Ability: 20tons
Release date: 2024-01-05

Hebei Kingfiner Technology Development Co.Ltd

Product: Triptolide 38748-32-2
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 50000kg
Release date: 2024-05-15

Wuhan Boyuan Import & Export Co., LTD

Product: Triptolide 38748-32-2
Price: US $50.00/KG
Min. Order: 10KG
Purity: 99.50%
Supply Ability: 1000kg
Release date: 2023-04-06

38748-32-2, TriptolideRelated Search:

WILFORLIDE A Bortezomib Etoposide Selumetinib Dasatinib MG-132 Vatalanib Dihydrochloride Triptonide Celastrol 16-Hydroxytriptolide 2BETA-HYDROXY-TRIPTOLIDE,(2-beta)-triptoli Omtriptolide Wilforlide EPI-TRIPTOLIDE,TRIPTOLIDE, EPI- TRIPTOLIDE, EPI-(P) Triptolide Triptolide TRIPTOLIDE(PRIMARY STANDARD)

PG490

TRIPTOLIDE

TRIPTOLIDE, TRIPTERYGIUM WILFORDII

,7as,7bs,8as,8bs)-

8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-,(3bs,4as,5as,6r,6ar

triptolid

Triptolide, >=98%

TriptolidefromTripterygium wilfordii≥ 98% (HPLC)

Triptolide(TPL)

Thunder God Vine Extract

Triptolide, 98%, from Tripterygium

TRIPTOLIDE TLC

TRIPTOLIDE95%

TRIPTOLIDE(P)

TRIPTONIDE(P)

(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one

NSC 163062

TRIPTOLIDE(RG)(PLEASE CALL)

Tripterygium wilfordii Hook.f.

Triptolide(PG490,Triptolid)

Triptolide(PG490)

(3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

Triptolide-d3 (Major, Contains d0)

TripterygiuM wilfordii extractive

Trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-

Triptolide, froM TripterygiuM

Triptolide 38748-32-2

professional supplier Triptolide 38748-32-2

Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

Triptolide Triptolide

(5bS,6aS,7aS,8R,8aR,9aS,9bS,10aS,10bS)-8-Hydroxy-8a-isopropyl-10b-methyl-1,5,5b,6,6a,8,8a,9a,9b,10b-decahydrotris(oxireno)[2',3':4b,5

2''',3''':8a,9]phenanthro[1,2-c]furan-3(2H)-one

riptolide

AZD6244 sulfate salt

Triptolide ex. Tripterigium Wilfordii for cell culture, 98%

1H-Pyrrole-2,5-dione,4-methyl-

Triptolide (ZCI)

2''',3''':8a,9]phenanthro[1,2-c]furan-3(2H)-one

(5bS,6aS,7aS,8R,8aR,9aS,9bS,10aS,10bS)-8-Hydroxy-8a-isopropyl-10b-methyl-1,5,5b,6,6a,8,8a,9a,9b,10b-decahydrotris(oxireno)[2',3':4b,5

Triptolide-RM

38748-32-2

8748-32-2

Immune System Regulation

Immunomodulators and Antibiotics

Immune Cell Signaling and Blood

Cell Biology

Cell Signaling and Neuroscience

BioChemical

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

Chiral Reagents

Heterocycles

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Natural Anti-cancer Medical Materials and It's Derivatives