Vatalanib Dihydrochloride

Product Name: Vatalanib Dihydrochloride
CAS No.: 212141-51-0
Chemical Name: Vatalanib Dihydrochloride
Synonyms: PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl
CBNumber: CB21176854
Molecular Formula: C20H17Cl3N4
Formula Weight: 419.74
MOL File: 212141-51-0.mol

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Vatalanib Dihydrochloride Property

Melting point:: 268-2700C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
form: solid
color: White or off-white
Water Solubility: H2O: 2mg/mL, clear
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 212141-51-0

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Safety

Risk Statements: 36/37/38
Safety Statements: 24/25
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2498
Product name: Vatalanib dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $78.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2498
Product name: Vatalanib dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $184.8
Updated: 2025/07/31

Cayman Chemical

Product number: 14868
Product name: Vatalanib (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $51
Updated: 2024/03/01

Cayman Chemical

Product number: 14868
Product name: Vatalanib (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 14868
Product name: Vatalanib (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $165
Updated: 2024/03/01

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Vatalanib Dihydrochloride Chemical Properties,Usage,Production

Description

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC₅₀ values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC₅₀ = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Chemical Properties

White to Off-White Crystalline Powder

Uses

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.

Uses

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

in vivo

Vatalanib induces dose-dependent inhibition of the angiogenic response to VEGF and PDGF in both a growth factor implant model and a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg). In the same dose range, Vatalanib also inhibits the growth and metastasesof several human carcinomas in nude mice without significant effect on circulating blood cells or bone marrow leukocytes^[1].

IC 50

VEGFR2: 37 nM (IC₅₀)

References

[1] J M WOOD. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.[J]. Cancer research, 2000, 60 8: 2178-2189.
[2] ANDERSON K. The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment[J]. European Journal of Haematology, 2008, 70 4: 266-267. DOI:10.1034/j.1600-0609.2003.t01-1-01067.x

Vatalanib Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Vatalanib Dihydrochloride Suppliers

Canada 1 China 133 India 3 United Kingdom 2 United States 22 Global 161

J & K SCIENTIFIC LTD.

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Chembest Research Laboratories Limited

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Chemsky（shanghai）International Co.,Ltd.

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Jinan Trio PharmaTech Co., Ltd.

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Shanghai civi chemical technology co.,Ltd

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NCE Biomedical Co.,Ltd.

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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

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Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
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Shanghai Aladdin Bio-Chem Technology Co.,LTD

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View Lastest Price from Vatalanib Dihydrochloride manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Vatalanib Dihydrochloride 212141-51-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-05-20

Career Henan Chemical Co

Product: Vatalanib Dihydrochloride 212141-51-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

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CGP-79787 Dihydrochlorid

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CGP-79787 Dihydrochloride

Vatalanib 2hcl((ZK-222584,PTK 787)

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CGP-79787

CGP-79787D

PTK/ZK

ZK-222584

CGP-79787, PTK 787, ZK222584

N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride

ZK 222584 (cpg-79787) 2HCl

Vatalanib 2HCl (PTK787)

Vatalanib (PTK787) 2HCl

Vatalanib (hydrochloride)

Vatalanib dihydrochloride(2HCL)

Vatalanib (PTK787) diHydrochloride

CS-465

ZK-222584 dihydrochloride

CGP-797870 dihydrochloride

PTK787 dihydrochloride

Vatalanib Dihydrochloride USP/EP/BP

1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2)

CGP79787) 2HCl

Vatalinib 2HCl

Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor

Vatalanib dihydrochloride, 10 mM in DMSO

Vatalanib dihydrochloride/212141-51-0/98%

212141-51-0

C20H17Cl3N4

C20H15ClN42HCl

C20H15Cl2N42HCl

C20H15ClN42ClH

Heterocycles

Tyrosine Kinase Inhibitors

Antineoplastic

Intermediates & Fine Chemicals

Pharmaceuticals

Inhibitors