Vatalanib succinate
- Product Name
- Vatalanib succinate
- CAS No.
- 212142-18-2
- Chemical Name
- Vatalanib succinate
- Synonyms
- VATALANIB SUCCINATE;N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate;N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate;N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine butanedioate;butanedioicacid,N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
- CBNumber
- CB5837212
- Molecular Formula
- C24H21ClN4O4
- Formula Weight
- 464.9
- MOL File
- 212142-18-2.mol
Vatalanib succinate Property
- Melting point:
- 195°
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H360May damage fertility or the unborn child
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- V0198
- Product name
- Vatalanib Succinate
- Packaging
- 25MG
- Price
- $252
- Updated
- 2025/07/31
- Product number
- 5680
- Product name
- Vatalanibsuccinate
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $117
- Updated
- 2021/12/16
- Product number
- 5680
- Product name
- Vatalanibsuccinate
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $491
- Updated
- 2021/12/16
- Product number
- V995035
- Product name
- VatalanibSuccinate
- Packaging
- 50mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- V995035
- Product name
- VatalanibSuccinate
- Packaging
- 100mg
- Price
- $430
- Updated
- 2021/12/16
Vatalanib succinate Chemical Properties,Usage,Production
Uses
Vatalanib Succinate is a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases.
Definition
ChEBI: A succinate salt obtained by combining vatalanib with one molar equivalent of succinic acid. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit.
in vivo
After oral dosing (50 mg/kg) to mice, plasma concentrations of Vatalanib (PTK787) remain above 1 μM for more than 8 h. Vatalanib (PTK787) induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model, as well as a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg)[1].
IC 50
KDR: 37 nM (IC50); Flt-1: 77 nM (IC50); Flt-4: 730 nM (IC50)
storage
Store at -20°C
Vatalanib succinate Preparation Products And Raw materials
Raw materials
Preparation Products
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