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Vatalanib succinate

Product Name
Vatalanib succinate
CAS No.
212142-18-2
Chemical Name
Vatalanib succinate
Synonyms
VATALANIB SUCCINATE;N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate;N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate;N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine butanedioate;butanedioicacid,N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
CBNumber
CB5837212
Molecular Formula
C24H21ClN4O4
Formula Weight
464.9
MOL File
212142-18-2.mol
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Vatalanib succinate Property

Melting point:
195°
storage temp. 
2-8°C
solubility 
Soluble in DMSO
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
V0198
Product name
Vatalanib Succinate
Packaging
25MG
Price
$252
Updated
2025/07/31
Tocris
Product number
5680
Product name
Vatalanibsuccinate
Purity
≥99%(HPLC)
Packaging
10
Price
$117
Updated
2021/12/16
Tocris
Product number
5680
Product name
Vatalanibsuccinate
Purity
≥99%(HPLC)
Packaging
50
Price
$491
Updated
2021/12/16
TRC
Product number
V995035
Product name
VatalanibSuccinate
Packaging
50mg
Price
$275
Updated
2021/12/16
TRC
Product number
V995035
Product name
VatalanibSuccinate
Packaging
100mg
Price
$430
Updated
2021/12/16
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Vatalanib succinate Chemical Properties,Usage,Production

Uses

Vatalanib Succinate is a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases.

Definition

ChEBI: A succinate salt obtained by combining vatalanib with one molar equivalent of succinic acid. It is a multi-targeted tyrosine kinase inhibitor for all isoforms of VEGFR, PDGFR and c-Kit.

in vivo

After oral dosing (50 mg/kg) to mice, plasma concentrations of Vatalanib (PTK787) remain above 1 μM for more than 8 h. Vatalanib (PTK787) induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model, as well as a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg)[1].

IC 50

KDR: 37 nM (IC50); Flt-1: 77 nM (IC50); Flt-4: 730 nM (IC50)

storage

Store at -20°C

Vatalanib succinate Preparation Products And Raw materials

Raw materials

Preparation Products

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Vatalanib succinate Suppliers

China 29 Europe 2 Germany 1 India 1 United Kingdom 1 United States 11 USA 1 Global 46
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71

212142-18-2, Vatalanib succinateRelated Search:

Disodium succinate Metroprolol succinate Vatalanib base Erythromycin ethylsuccinate 6alpha-Methylprednisolone sodium succinate Succinic acid iron succinate Vatalanib Dihydrochloride Vatalanib succinate

  • VATALANIB SUCCINATE
  • N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine butanedioate
  • N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine succinate
  • N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine succinate
  • butanedioicacid,N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine
  • 212142-18-2
  • C24H21ClN4O4