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Vatalanib Dihydrochloride

Product Name
Vatalanib Dihydrochloride
CAS No.
212141-51-0
Chemical Name
Vatalanib Dihydrochloride
Synonyms
PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl
CBNumber
CB21176854
Molecular Formula
C20H17Cl3N4
Formula Weight
419.74
MOL File
212141-51-0.mol
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Vatalanib Dihydrochloride Property

Melting point:
268-2700C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
form 
solid
color 
White or off-white
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference
212141-51-0
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Safety

Risk Statements 
36/37/38
Safety Statements 
24/25
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2498
Product name
Vatalanib dihydrochloride
Purity
≥98% (HPLC)
Packaging
10mg
Price
$76
Updated
2024/03/01
Sigma-Aldrich
Product number
SML2498
Product name
Vatalanib dihydrochloride
Purity
≥98% (HPLC)
Packaging
50mg
Price
$257
Updated
2024/03/01
Cayman Chemical
Product number
14868
Product name
Vatalanib (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$51
Updated
2024/03/01
Cayman Chemical
Product number
14868
Product name
Vatalanib (hydrochloride)
Purity
≥98%
Packaging
25mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
14868
Product name
Vatalanib (hydrochloride)
Purity
≥98%
Packaging
50mg
Price
$165
Updated
2024/03/01
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Vatalanib Dihydrochloride Chemical Properties,Usage,Production

Description

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC50 values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC50 = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Chemical Properties

White to Off-White Crystalline Powder

Uses

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.

Uses

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

References

1) Wood?et al. (2000),?PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration;? Cancer Res.,?60?2178 2) Lin?et al. (2002),?The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in bone marrow microenvironment;? Cancer Res.,?62?5019

Vatalanib Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Vatalanib Dihydrochloride Suppliers

Canada 1 China 100 India 3 United Kingdom 2 United States 21 Global 127
Manus Aktteva
Tel
--
Fax
--
Email
info@manusaktteva.in
Country
India
ProdList
581
Advantage
34
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from Vatalanib Dihydrochloride manufacturers

Career Henan Chemical Co
Product
Vatalanib Dihydrochloride 212141-51-0
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2018-12-24

212141-51-0, Vatalanib DihydrochlorideRelated Search:

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  • Vatalanib dihydrochloride (PTK787)
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  • PTK/ZK
  • ZK-222584
  • CGP-79787, PTK 787, ZK222584
  • N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine dihydrochloride
  • ZK 222584 (cpg-79787) 2HCl
  • Vatalanib 2HCl (PTK787)
  • Vatalanib (PTK787) 2HCl
  • Vatalanib (hydrochloride)
  • Vatalanib dihydrochloride(2HCL)
  • Vatalanib (PTK787) diHydrochloride
  • CS-465
  • ZK-222584 dihydrochloride
  • CGP-797870 dihydrochloride
  • PTK787 dihydrochloride
  • Vatalanib Dihydrochloride USP/EP/BP
  • 1-Phthalazinamine,N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, hydrochloride (1:2)
  • CGP79787) 2HCl
  • Vatalinib 2HCl
  • 212141-51-0
  • C20H17Cl3N4
  • C20H15ClN42HCl
  • C20H15Cl2N42HCl
  • C20H15ClN42ClH
  • Heterocycles
  • Tyrosine Kinase Inhibitors
  • Antineoplastic
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Inhibitors