Vatalanib Dihydrochloride

ChemicalBook > CAS DataBase List > Vatalanib Dihydrochloride

Vatalanib Dihydrochloride

Product Name: Vatalanib Dihydrochloride
CAS No.: 212141-51-0
Chemical Name: Vatalanib Dihydrochloride
Synonyms: PTK/ZK;CS-465;CGP-79787;ZK-222584;CGP-79787D;CGP79787) 2HCl;Vatalinib 2HCl;PTK787 dihydrochloride;Vatalanib 2HCl (PTK787);Vatalanib (PTK787) 2HCl
CBNumber: CB21176854
Molecular Formula: C20H17Cl3N4
Formula Weight: 419.74
MOL File: 212141-51-0.mol

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Vatalanib Dihydrochloride Property

Melting point:: 268-2700C
storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO (up to 20 mg/ml with warming) or in Water (up to 100 mg/ml)
form: solid
color: White or off-white
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 212141-51-0

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Safety

Risk Statements: 36/37/38
Safety Statements: 24/25
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2498
Product name: Vatalanib dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $76
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2498
Product name: Vatalanib dihydrochloride
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 14868
Product name: Vatalanib (hydrochloride)
Purity: ≥98%
Packaging: 10mg
Price: $51
Updated: 2024/03/01

Cayman Chemical

Product number: 14868
Product name: Vatalanib (hydrochloride)
Purity: ≥98%
Packaging: 25mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 14868
Product name: Vatalanib (hydrochloride)
Purity: ≥98%
Packaging: 50mg
Price: $165
Updated: 2024/03/01

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Vatalanib Dihydrochloride Chemical Properties,Usage,Production

Description

Vatalanib is an antagonist of the VEGF receptors, inhibiting the receptor tyrosine kinase activities of VEGFR1 (Flt1), VEGFR2 (KDR), and VEGFR3 (Flt4) with IC₅₀ values of 77, 37, and 190 nM, respectively. It less potently inhibits PDGF and c-Kit (IC₅₀ = 600 and 700 nM) and has no effect on a large panel of additional kinases. Vatalanib completely blocks retinal neovascularization in oxygen-induced ischemic retinopathy in mice, suggesting its use in diabetic retinopathy and other diseases featuring aberrant vascular development.

Chemical Properties

White to Off-White Crystalline Powder

Uses

Vascular endothelial growth factor (VEGF) receptor tyrosine kinase inhibitor. Antineoplastic.

Uses

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

References

1) Wood?et al. (2000),?PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration;? Cancer Res.,?60?2178 2) Lin?et al. (2002),?The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in bone marrow microenvironment;? Cancer Res.,?62?5019

Vatalanib Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vatalanib Dihydrochloride manufacturers

Career Henan Chemical Co

Product: Vatalanib Dihydrochloride 212141-51-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-24

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212141-51-0

C20H17Cl3N4

C20H15ClN42HCl

C20H15Cl2N42HCl

C20H15ClN42ClH

Heterocycles

Tyrosine Kinase Inhibitors

Antineoplastic

Intermediates & Fine Chemicals

Pharmaceuticals

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