ChemicalBook > CAS DataBase List > 2-(1-Piperazinyl)pyrimidine

2-(1-Piperazinyl)pyrimidine

Product Name
2-(1-Piperazinyl)pyrimidine
CAS No.
20980-22-7
Chemical Name
2-(1-Piperazinyl)pyrimidine
Synonyms
1-(2-PYRIMIDYL)PIPERAZINE;1-pp;PMPRZ;mj13653;GOSO-003;BUSPIRON?A;AKOS BBS-00003690;TIMTEC-BB SBB003913;RARECHEM AH CK 0195;Pyrimidinylpiperazine
CBNumber
CB2169600
Molecular Formula
C8H12N4
Formula Weight
164.21
MOL File
20980-22-7.mol
More
Less

2-(1-Piperazinyl)pyrimidine Property

Melting point:
32-34°C
Boiling point:
277 °C (lit.)
Density 
1.158 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.587(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Liquid After Melting
pka
8.68±0.10(Predicted)
color 
Clear yellow
Water Solubility 
almost transparency
Sensitive 
Hygroscopic
BRN 
151178
InChIKey
MRBFGEHILMYPTF-UHFFFAOYSA-N
CAS DataBase Reference
20980-22-7(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
3
RTECS 
UV9702000
TSCA 
Yes
HazardClass 
8
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2845
Product name
Buspirone Related Compound A
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
2X100MG
Price
$521
Updated
2025/07/31
Sigma-Aldrich
Product number
1078573
Product name
Buspirone Related Compound A
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
2x75mg
Price
$1330
Updated
2025/07/31
Sigma-Aldrich
Product number
421235
Product name
1-(2-Pyrimidyl)piperazine
Purity
98%
Packaging
5g
Price
$35.5
Updated
2023/06/20
TCI Chemical
Product number
P1110
Product name
1-(2-Pyrimidyl)piperazine
Purity
>98.0%(GC)
Packaging
5g
Price
$24
Updated
2025/07/31
TCI Chemical
Product number
P1110
Product name
1-(2-Pyrimidyl)piperazine
Purity
>98.0%(GC)
Packaging
25g
Price
$69
Updated
2025/07/31
More
Less

2-(1-Piperazinyl)pyrimidine Chemical Properties,Usage,Production

Chemical Properties

clear yellow liquid after melting

Uses

2-(1-Piperazinyl)pyrimidine (Buspirone EP Impurity A) is the major metabolite of Tandospirone (T006430).

Uses

The major metabolite of Tandospirone.

Definition

ChEBI: 1-(2-Pyrimidyl)piperazine is a N-arylpiperazine.

Synthesis Reference(s)

The Journal of Organic Chemistry, 18, p. 1484, 1953 DOI: 10.1021/jo50017a004

General Description

1-(2-Pyrimidyl)piperazine is a piperazine-based derivative. It is a metabolite of buspirone.

Synthesis

110-85-0

1722-12-9

20980-22-7

Generic method: 2-chloro-4,6-disubstituted pyrimidines (17) were prepared by reaction of the diazonium salt of 4,6-disubstituted pyrimidin-2-amine (16) with concentrated hydrochloric acid and ZnCl?[35]. Compound 18 was synthesized with reference to the method of literature [32] with modifications. To a stirred solution of piperazine (45 mmol) and K?CO? (16.5 mmol) in water (20 mL) was added 2-chloro-4,6-disubstituted pyrimidine (17) (18 mmol) in batches at 50-65 °C. The reaction mixture was stirred at 60-65 °C for 1 hour and subsequently cooled to 35 °C. The solid by-product 1,4-bispyrimidinylpiperazine was removed by filtration, the filtrate was extracted three times with chloroform, the organic phase was dried with Na?SO? and concentrated under reduced pressure to give compound 18, which could be used in the subsequent reaction without further purification.18a: yellow oil, 88% yield.

References

[1] Chinese Journal of Chemistry, 2015, vol. 33, # 10, p. 1124 - 1134
[2] European Journal of Medicinal Chemistry, 2016, vol. 117, p. 167 - 178
[3] Organic Letters, 2016, vol. 18, # 20, p. 5272 - 5275
[4] Journal of the American Chemical Society, 2017, vol. 139, # 33, p. 11357 - 11360
[5] Patent: CN107216318, 2017, A. Location in patent: Paragraph 0021; 0024; 0027

2-(1-Piperazinyl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

Buspirone Tandospirone Doxazosin
More
Less

2-(1-Piperazinyl)pyrimidine Suppliers

Americas 1 Belgium 2 Canada 3 China 306 Czech 1 Europe 2 France 2 Germany 9 India 18 Japan 4 Slovakia 1 Switzerland 2 The Netherlands 1 Ukraine 3 United Kingdom 10 United States 45 Global 410
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Aceschem Inc.
Tel
+1-817863-6948 +1-（817）863-6948
Email
sales@aceschem.com
Country
United States
ProdList
19632
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Frontier Scientific Services, Inc.
Tel
--
Fax
--
Email
customerservice@frontierssi.com
Country
United States
ProdList
1575
Advantage
0
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
Precursor Chemicals, Inc.
Tel
--
Fax
--
Email
info@precursorchem.com
Country
United States
ProdList
347
Advantage
51
ChemContract Research Inc.
Tel
--
Fax
--
Country
United States
ProdList
1526
Advantage
38
HDH Pharma, Inc.
Tel
--
Fax
--
Email
catalog@hdhpharma.com
Country
United States
ProdList
6248
Advantage
62
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
INDOFINE Chemical Company, Inc.
Tel
--
Fax
--
Email
chemical@indofinechemical.com
Country
United States
ProdList
6176
Advantage
69
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
Bio-Vin Research Laboratories
Tel
--
Fax
--
Email
sales@biovinresearch.com
Country
United States
ProdList
6210
Advantage
64
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
AMI GROUP COMPANIES, INDIA
Tel
--
Fax
--
Email
bhooshan@amidrugs.com
Country
United States
ProdList
111
Advantage
51
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
AB Chem Technologies, LLC
Tel
--
Fax
--
Email
sales@abchemtech.com
Country
United States
ProdList
1101
Advantage
46
Princeton BioMolecular Research, Inc.
Tel
--
Fax
--
Email
info@princetonbio.com
Country
United States
ProdList
6934
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
TimTec Corporation
Tel
--
Fax
--
Email
info@timtec.net
Country
United States
ProdList
6891
Advantage
68
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
ASDI Incorporated
Tel
--
Fax
--
Email
customerservice@asdi.net
Country
United States
ProdList
6922
Advantage
67
More
Less

View Lastest Price from 2-(1-Piperazinyl)pyrimidine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-(1-Piperazinyl)pyrimidine 20980-22-7
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
10000KGS
Release date
2025-05-26
Hebei Zhuanglai Chemical Trading Co Ltd
Product
2-(1-Piperazinyl)pyrimidine 20980-22-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20 ton
Release date
2024-11-13
Hebei Chuanghai Biotechnology Co., Ltd
Product
2-(1-Piperazinyl)pyrimidine 20980-22-7
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05

20980-22-7, 2-(1-Piperazinyl)pyrimidineRelated Search:

2-Ethylhexyl ferulate Piperazine Piperacillin 1-Methylpiperazine N-Aminoethylpiperazine Homopiperazine 2-Chloropyrimidine Dihydrochloride BUSPIRONE (D8) 3,3-Tetramethyleneglutarimide Buspirone EP Impurity F 8-(pyrimidin-2-yl)-5,8-diazaspiro[4.5]decan-5-ium chloride Buspirone Impurity 1 (Lactone of 6-Hydroxy Buspirone) 8-(4-Chlorobutyl)-8-azaspiro[4.5]decane-7,9-dione Buspirone EP Impurity H Buspirone Impurity 2 Buspirone N-Oxide Buspirone impurity 3

  • LABOTEST-BB LT00233196
  • AKOS BBS-00003690
  • 1-PYRIMIDYL PIPERAZINE
  • 2-(1-PIPERAZINYL)PYRIMIDINE
  • 2-PIPERAZINOPYRIMIDINE
  • 2-PIPERAZIN-1-YLPYRIMIDINE
  • 1-(2-PYRIMIDINYL)PIPERAZINE
  • 1-(2-PYRIMIDYL)PIPERAZINE
  • 1-Pyrimydinyl Piperazine
  • RARECHEM AH CK 0195
  • TIMTEC-BB SBB003913
  • PMPRZ
  • 1-(Pyrimidin-2-yl)piperazine 98%
  • 1-(2-PYRIMIDINYL)PIPERZINE
  • 1-(2-PYRIMIDINYL)PIPERZINE DIHYDROCHLORIDE
  • 2-(1-Piperazinyl)pyrimidine, 98+%
  • 1-(2-PYRIMIDYL)PIPERAZINE 98%
  • 1-(2-PYRIMIDYL)PIPERAZINE DIHYDROCHLORIDE, 98+%
  • 1-(2-Pyrimidyl)piperazine dihydrochloride
  • 1-(2-Pyrimidyl)piperazine ,98%
  • 2-Piperazinylpyrimidine
  • 2-(piperazine-1-yl)-pyriMidine
  • PyriMidine, 2-(1-piperazinyl)-
  • N - (2 - pyriMidine base) piperazine
  • GOSO-003
  • Buspirone Impurity 1(Buspirone EP Impurity A)
  • Buspirone EP Impurity A
  • 2-(1-Piperazinyl)pyrimidine,99%
  • Buspirone Related Compound A
  • 1-pp
  • 2-(1-piperazinyl)-pyrimidin
  • 4-(2-pyrimidinyl)piperazine
  • mj13653
  • n-(2-pyrimidinyl)piperazine
  • 2-(1-Piperazino)pyrimidine
  • 1-(Pyrimidin-2-yl)piperazine
  • 2-(Piperazin-1-yl)pyrimidine 98%
  • 1-(2-Pyrimidinyl)piperazine 98% min
  • 2-(2-Piperazinyl)pyrimidine
  • N-(2-pyridinyl)piperazine
  • 1-(2-Pyrimidyl)piperazine&gt
  • Buspirone EP Impurity A/ Buspirone Related Compound A
  • Buspirone EP Impurity AQ: What is Buspirone EP Impurity A Q: What is the CAS Number of Buspirone EP Impurity A Q: What is the storage condition of Buspirone EP Impurity A Q: What are the applications of Buspirone EP Impurity A
  • TIANFU CHEM 2-(1-Piperazinyl)pyrimidine
  • Buspirone Related Compound A (75 mg x 2) (2-(Piperazin-1-yl)pyrimidine) (1078573)
  • Di2-(Piperazin-1-yl)pyrimidine
  • RSYY（Donepezil Hydrochloride)-16
  • 2-Piperazinyl Pyrimidine, Hydrobromide（1：2）
  • BUSPIRON?A
  • Buspirone EP Impurity A Buspirone USP RC A
  • 2-(1-Piperazinyl)pyrimidine, 10 mM in DMSO
  • Pyrimidinylpiperazine
  • Buspirone EP Impurity A (Buspirone USP Related Compound A)
  • 20980-22-7
  • C8H13N4
  • C8H12N4
  • Heterocyclic Building Blocks
  • Building Blocks