ChemicalBook > CAS DataBase List > Vatalanib base

Vatalanib base

Product Name: Vatalanib base
CAS No.: 212141-54-3
Chemical Name: Vatalanib base
Synonyms: VataL;VATALANIB;PTK787 2HCl;Vatalanib HCl;Vatalanib 2HCL;VATALANIB BASE;PTK787 free base;PTK/ZK free base;Vatalanib (PTK787);anib (PTK787) 2HCL
CBNumber: CB2173616
Molecular Formula: C20H15ClN4
Formula Weight: 346.81
MOL File: 212141-54-3.mol

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Vatalanib base Property

Melting point:: 209-212°
Boiling point:: 587.8±50.0 °C(Predicted)
Density: 1.330±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: ≥16.85 mg/mL in DMSO; ≥3.0125 mg/mL in EtOH with gentle warming and ultrasonic; ≥32.53 mg/mL in H2O with gentle warming and ultrasonic
form: solid
pka: 5.46±0.10(Predicted)
color: Light yellow to yellow

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3969
Product name: Vatalanib
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

Apolloscientific

Product number: BIFK0006
Product name: Vatalanib
Packaging: 5mg
Price: $73
Updated: 2021/12/16

Apolloscientific

Product number: BIFK0006
Product name: Vatalanib
Packaging: 10mg
Price: $116
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0004576
Product name: VATALANIB
Purity: 95.00%
Packaging: 10MG
Price: $154.35
Updated: 2021/12/16

Apolloscientific

Product number: BIFK0006
Product name: Vatalanib
Packaging: 25mg
Price: $218
Updated: 2021/12/16

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Vatalanib base Chemical Properties,Usage,Production

Uses

Vatalanib (PTK787) is an inhibitor of VEGFR2/KDR, Flt-1 and c-Kit with IC50 of 37 nM, 77 nM and 730 nM, respectively.

Uses

anti-viral

Definition

ChEBI: A member of the class of phthalazines that is phthalazine in which the hydrogens at positions 1 and 4have been replaced by a p-chlorophenylamino group and a pyridin-4-ylmethyl group, respectively. It is a multi-targeted tyrosine kinase inhibit r for all isoforms of VEGFR, PDGFR and c-Kit.

in vivo

Vatalanib induces dose-dependent inhibition of the angiogenic response to VEGF and PDGF in both a growth factor implant model and a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg). In the same dose range, Vatalanib also inhibits the growth and metastasesof several human carcinomas in nude mice without significant effect on circulating blood cells or bone marrow leukocytes^[1].

IC 50

VEGFR2: 37 nM (IC₅₀)

Vatalanib base Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Vatalanib base manufacturers

RongNa Biotechnology Co.,Ltd

Product: Vatalanib base 212141-54-3
Price: US $10.00/ASSAYS
Min. Order: 1ASSAYS
Purity: 99%
Supply Ability: 1 ton
Release date: 2025-08-22

Career Henan Chemical Co

Product: Vatalanib base 212141-54-3
Price: US $1.00/g
Min. Order: 100g
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-23

Career Henan Chemical Co

Product: Vatalanib base 212141-54-3
Price: US $1.00/g
Min. Order: 100g
Purity: 98%min
Supply Ability: G/KG/T
Release date: 2019-12-23

212141-54-3, Vatalanib baseRelated Search:

Chlorodimethylphenylsilane Trimethylphenylammonium chloride 4-Methylpyridine 2,6-Lutidine 2-Chloro-5-chloromethylpyridine Triethanolamine Dibenzylamine Bis(2-ethylhexyl)amine 2,4,6-Collidine Triallylamine Azamethiphos Vatalanib Dihydrochloride 4-METHOXY-PYRIDINE-2-CARBOXYLIC ACID AMIDE 4-(4-AMINOPHENOXY)PYRIDINE Sorafenib 4-(4-Aminophenoxy)-N-methylpicolinamide Vatalanib base

N-(4-Chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine

N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)- 1-Phthalazinamine

1-PhthalazinaMine, N-(4-chlorophenyl)-4-(4-pyridinylMethyl)-

Vatalanib (PTK787) Dihydrochloride Base

Pynasunate, ZK222584, CGP-79787, PTK 787

(4-Chloro-phenyl)-(4-pyridin-4-ylmethyl-phthalazin-1-yl)-amine

Vatalanib free base (PTK787 free base

PTK787 free base

PTK787 FREE BASE; PTK/ZK FREE BASE; CGP-79787 FREE BASE; ZK-222584 FREE BASE

CGP-79787 free base

PTK/ZK free base

ZK-222584 free base)

PTK787 2HCl

ZK 222584 (CPG-79787) 2HCL;PTK787 2HCL

Vatalanib (free base)

VATALANIB

SORAFENIB BASE VATALANIB

Vatalanib 2HCL

VATALANIB BASE

Vatalanib (PTK787)

anib (PTK787) 2HCL

VataL

Vatalanib free bas

Vatalanib HCl

Vatalanib free base (PTK-787

212141-54-3

Antineoplastic