BOC-D-THR-OH
- Product Name
- BOC-D-THR-OH
- CAS No.
- 55674-67-4
- Chemical Name
- BOC-D-THR-OH
- Synonyms
- BOC-D-THR;BOC-D-THR-OH;BOC-D-THREONINE;N-Boc-L-threonine;BOC-D-THR-OH USP/EP/BP;BOC-D-THREONINE extrapure;N-ALPHA-T-BOC-D-THREONINE;Boc-D-threonine≥ 98% (HPLC);BOC-D-Threonine(BOC-D-Thr-OH);N-Boc-D-threonine Boc-D-Thr-OH
- CBNumber
- CB2177386
- Molecular Formula
- C9H17NO5
- Formula Weight
- 219.24
- MOL File
- 55674-67-4.mol
BOC-D-THR-OH Property
- Melting point:
- 81 °C
- refractive index
- 9 ° (C=1, AcOH)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- form
- Solid
- color
- White to Almost white
- Water Solubility
- Slightly soluble in water.
- CAS DataBase Reference
- 55674-67-4(CAS DataBase Reference)
Safety
- HS Code
- 29225090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.53102
- Product name
- Boc-D-Thr-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 5 g
- Price
- $63
- Updated
- 2025/07/31
- Product number
- 8.53102
- Product name
- Boc-D-Thr-OH
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 25 g
- Price
- $628
- Updated
- 2025/07/31
- Product number
- B2990
- Product name
- N-(tert-Butoxycarbonyl)-D-threonine
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $335
- Updated
- 2025/07/31
- Product number
- B668000
- Product name
- N-Boc-D-threonine
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
- Product number
- 264831
- Product name
- Boc-D-threonine
- Packaging
- 5g
- Price
- $360
- Updated
- 2021/12/16
BOC-D-THR-OH Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
It is known to inhibit growth and cell wall synthesis of Mycobacterium smegmatis. Also used as a synthetic intermediate for the production of chiral antibiotics.
reaction suitability
reaction type: Boc solid-phase peptide synthesis
Synthesis
28954-12-3
24424-99-5
2592-18-9
The general procedure for the synthesis of (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutyric acid from (2S,3S)-2-amino-3-hydroxybutyric acid and di-tert-butyl dicarbonate is as follows: 1. di-tert-butyl dicarbonate (550 mg, 2.52 mmol) was added to a mixture of methanol (2.5 mL) and water (2.5 mL) containing L-isothreonine (250 mg, 2.10 mmol) and sodium bicarbonate (529 mg, 6.30 mmol) at 0 °C. 2. The reaction mixture was gradually warmed to room temperature and stirred continuously at room temperature for 18 hours. 3. Upon completion of the reaction, the methanol was removed by concentration and the remaining aqueous phase was adjusted to pH 3~4 with 6N hydrochloric acid solution. 4. The acidified aqueous phase was extracted with ether (3 times) and all organic phases were combined. 5. The organic phase was washed with water and brine sequentially, and then dried with anhydrous sodium sulfate. 6. The desiccant was removed by filtration, and the filtrate was concentrated under vacuum and further dried under vacuum for 24 h. (2R,3S)-2-((tert-butoxycarbonyl)amino)-3-hydroxybutyric acid (304 mg) was obtained as a white solid. Product identification: LCMS retention time (Rt) = 0.36 min; mass spectrum (MS) m/z 220 [M + H]+, m/z 218 [M-H]-.
References
[1] Organic and Biomolecular Chemistry, 2018, vol. 16, # 38, p. 6935 - 6960
[2] Journal of the American Chemical Society, 2000, vol. 122, # 41, p. 10214 - 10215
[3] Journal of the American Chemical Society, 2003, vol. 125, # 7, p. 1877 - 1887
[4] Journal of Organic Chemistry, 1982, vol. 47, # 26, p. 5160 - 5167
[5] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 16, p. 4329 - 4332
BOC-D-THR-OH Preparation Products And Raw materials
Raw materials
Preparation Products
BOC-D-THR-OH Suppliers
- Tel
- --
- Fax
- --
- swiss@sennchem.com
- Country
- Switzerland
- ProdList
- 3143
- Advantage
- 71
View Lastest Price from BOC-D-THR-OH manufacturers
- Product
- Boc-D-Thr-OH 55674-67-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T
- Release date
- 2023-11-14
- Product
- BOC-D-THR-OH 55674-67-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 95%-99%
- Supply Ability
- as request
- Release date
- 2018-12-24