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D-Threonine

Product Name
D-Threonine
CAS No.
632-20-2
Chemical Name
D-Threonine
Synonyms
H-D-THR-OH;D-Thr-OH;D-THREONINE, ALLO-FREE;(2R,3S)-2-AMino-3-hydroxybutanoic acid;d-threonin;D-Theronine;D-THREONINE;(r)-threonine;D-Threonine,98%;D-(+)-THREONINE
CBNumber
CB3489099
Molecular Formula
C4H9NO3
Formula Weight
119.12
MOL File
632-20-2.mol
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D-Threonine Property

Melting point:
274 °C
alpha 
28 º (c=6, water)
Boiling point:
222.38°C (rough estimate)
Density 
1.3126 (rough estimate)
refractive index 
28 ° (C=3, H2O)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
H2O: soluble
pka
2.19±0.10(Predicted)
form 
Crystals or Crystalline Powder
color 
White
Water Solubility 
soluble
Merck 
9380
BRN 
1721643
InChIKey
AYFVYJQAPQTCCC-STHAYSLISA-N
CAS DataBase Reference
632-20-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
24/25-37/39-26
WGK Germany 
3
RTECS 
XO8580000
HS Code 
29225000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T8250
Product name
D-Threonine
Purity
≥98% (TLC)
Packaging
5g
Price
$57.2
Updated
2024/03/01
Sigma-Aldrich
Product number
T8250
Product name
D-Threonine
Purity
≥98% (TLC)
Packaging
25g
Price
$128.4
Updated
2024/03/01
TCI Chemical
Product number
T0228
Product name
D-(+)-Threonine
Purity
>98.0%(T)
Packaging
25g
Price
$97
Updated
2024/03/01
TCI Chemical
Product number
T0228
Product name
D-(+)-Threonine
Purity
>98.0%(T)
Packaging
100g
Price
$287
Updated
2024/03/01
Alfa Aesar
Product number
B21177
Product name
D-Threonine, 99%
Packaging
5g
Price
$34.65
Updated
2024/03/01
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D-Threonine Chemical Properties,Usage,Production

Description

D-threonine is the D-form of threonine, which is a kind of amino acids. It can be used for the preparation of enantiomerically pure 1, 3-butanediol. It is also used as the intermediate during the preparation of chiral compounds such as antibiotics. D-threonine is an effective chiral pool reagent which contains an extra stereo-center. For example, people has recently used it as the starting material for total synthesis of protected legionaminic acid.

Chemical Properties

white crystalline powder or crystals

Uses

D-Threonine is the unnatural isomer of L-Threonine (T405500) and is known to inhibit growth and cell wall synthesis of Mycobacterium smegmatis. D-Threonine is also used as a synthetic intermediate for the production of chiral antibiotics. It is a steroisomer of the proteinogenic amino acid L-threonine. It has the potential to treat hypostatic leg ulceration.

Definition

ChEBI: D-threonine is an optically active form of threonine having D-configuration. It has a role as a Saccharomyces cerevisiae metabolite. It is a threonine and a D-alpha-amino acid. It is a conjugate base of a D-threoninium. It is a conjugate acid of a D-threoninate. It is an enantiomer of a L-threonine. It is a tautomer of a D-threonine zwitterion.

Application

D-Threonine is a steroisomer of the proteinogenic amino acid L-threonine. D-threonine is an important organic chiral source, mainly used in the fields of chiral drugs, chiral additives, chiral auxiliaries, etc., as a chiral source for chiral synthesis in the pharmaceutical industry. As an optically active organic acid, it has an irreplaceable role in the asymmetric synthesis of certain chiral compounds. It is mainly used to produce new broad-spectrum antibiotics, D-threonine, and threonine protection in peptide synthesis.

benefits

Threonine, pronounced three-uh-neen is one of nine essential amino acids your body needs to function properly. Aiding in maintaining healthy skin, teeth, collagen, elastin, and muscle tissue, it also helps with digestion, metabolism and preventing fat buildup in the liver. Threonine has been used to treat intestinal disorders and indigestion and can be used to help those suffering from depression and anxiety. Recently it has been shown to have promising sleep-promoting effects, which may prove helpful for those who have insomnia and other sleep disorders

General Description

D-Threonine is sweet and toxic in nature.It acts as an inhibitor of L-threonine dehydratase. L-Threonine orientations differ from D-Threonine, specifically in their angles. The L-Threonine tended to self assemble with other L-Threonine molecules while D-Threonine tended to self assemble with other D-Threonine molecules.

References

https://www.alfa.com/zh-cn/catalog/B21177/
Ikemi, Masahisa, et al. "D-Threonine Aldolase and Its Application to D -β-Hydroxy-£-Amino Acid Synthesis." (1992).
Paek SM, et al. "Recent Advances in Substrate-Controlled Asymmetric Induction Derived from Chiral Pool α-Amino Acids for Natural Product Synthesis." Molecules 21.7(2016):951.

D-Threonine Preparation Products And Raw materials

Raw materials

Preparation Products

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D-Threonine Suppliers

Sichuan HongRi Pharma-Tech Co., Ltd
Tel
028-88457210 18011480287
Fax
0838-2822568
Email
3213375147@qq.com
Country
China
ProdList
2021
Advantage
58
Huaibei Desung Biotech Co., Ltd.
Tel
0561-2337889 13515618601
Email
390478052@qq.com
Country
China
ProdList
1802
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15848
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
BeiJing Hwrk Chemicals Limted
Tel
0757-86329057 18501085097
Fax
010-89508210
Email
sales3.gd@hwrkchemical.com
Country
China
ProdList
7508
Advantage
55
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
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View Lastest Price from D-Threonine manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-D-Thr-OH 632-20-2
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98% 99%
Supply Ability
1T+
Release date
2023-09-20
Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
D-Threonine 632-20-2
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
99
Supply Ability
20tons
Release date
2024-02-06
Hebei Yanxi Chemical Co., Ltd.
Product
D-Threonine 632-20-2
Price
US $30.00-10.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-11-15

632-20-2, D-Threonine Related Search:


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  • Amino Acid Derivatives
  • Specialty Synthesis
  • Threonine
  • Peptide Synthesis
  • amino
  • amino acid
  • Threonine [Thr, T]
  • Amino Acids and Derivatives
  • alpha-Amino Acids
  • Amino Acids
  • Biochemistry
  • Amino Acids
  • PROTECTED AMINO ACID & PEPTIDES
  • Amino ACIDS SERIES
  • Miscellaneous
  • bc0001