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2-Aminoisobutyric Acid

Applications Description source
Product Name
2-Aminoisobutyric Acid
CAS No.
62-57-7
Chemical Name
2-Aminoisobutyric Acid
Synonyms
AIB;2-Amino-2-methylpropanoic acid;H-AIB-OH;Aib-OH;L-Aib-OH;2-METHYLALANINE;N-ME-ALA-OH;N-ME-ALANINE;H-ALPHA-METHYLALANINE;α-Aminoisobutyric acid
CBNumber
CB2182809
Molecular Formula
C4H9NO2
Formula Weight
103.12
MOL File
62-57-7.mol
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2-Aminoisobutyric Acid Property

Melting point:
≥300 °C
Boiling point:
193.35°C (rough estimate)
Density 
1.1602 (rough estimate)
refractive index 
1.4183 (estimate)
storage temp. 
Store below +30°C.
solubility 
Very easily soluble in water, poorly soluble in alcohol, insoluble in oils.
pka
2.36(at 25℃)
form 
Crystalline Powder
color 
White
Odor
Practically odorless in the dry state
Water Solubility 
SOLUBLE
Merck 
14,445
BRN 
506496
InChIKey
FUOOLUPWFVMBKG-UHFFFAOYSA-N
LogP
-0.163 (est)
CAS DataBase Reference
62-57-7(CAS DataBase Reference)
NIST Chemistry Reference
«alpha»-Aminoisobutanoic acid(62-57-7)
EPA Substance Registry System
Alanine, 2-methyl- (62-57-7)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
AY7000000
TSCA 
Yes
HazardClass 
IRRITANT
HS Code 
29224995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
850993
Product name
2-Aminoisobutyric acid
Purity
98%
Packaging
25g
Price
$64.2
Updated
2025/07/31
Sigma-Aldrich
Product number
850993
Product name
2-Aminoisobutyric acid
Purity
98%
Packaging
100g
Price
$130
Updated
2025/07/31
TCI Chemical
Product number
A0323
Product name
2-Aminoisobutyric Acid
Purity
>98.0%(T)
Packaging
25g
Price
$34
Updated
2025/07/31
TCI Chemical
Product number
A0323
Product name
2-Aminoisobutyric Acid
Purity
>98.0%(T)
Packaging
100g
Price
$93
Updated
2025/07/31
TCI Chemical
Product number
A0323
Product name
2-Aminoisobutyric Acid
Purity
>98.0%(T)
Packaging
500g
Price
$291
Updated
2025/07/31
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2-Aminoisobutyric Acid Chemical Properties,Usage,Production

Applications

2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes.

Description

2-Aminoisobutyric acid, also known as alpha-methylalanine or a-aminoisobutanoate, belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). 2-Aminoisobutyric acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. 2-Aminoisobutyric acid exists in all living organisms, ranging from bacteria to humans. Outside of the human body, 2-Aminoisobutyric acid has been detected, but not quantified in, milk (cow). This could make 2-aminoisobutyric acid a potential biomarker for the consumption of these foods. Aminoisobutyric acid is a nonprotein amino acid (is an end product of pyrimidine metabolism) excreted in the urine of about 5% of healthy individuals , and high excretion is an autosomal recessive phenotype.

source

2-aminoisobutyric acid is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. With the exception of a few bacteria, it is non-metabolisable, and therefore used in bioassays. It derives from a propionic acid and an isobutyric acid.

Chemical Properties

White crystalline powder

Uses

2-Aminoisobutyric Acid inotransferases which can be used as a diagnostic tool to predict type II diabetes.

Uses

2-Aminoisobutyric acid is a non- protein amino acid present in some antibiotics. It acts as a strong helix inducer in peptides. It is non-metabolisable used in bioassays.

Definition

ChEBI: A rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. With the exception of a few bacteria, it is non-metabolisable, and therefore used in bioassays.

Preparation

α-Aminoisobutyric Acid is prepared from Acetone (Blatt: Org. Synth. CoIl. vol. H, page 29, 1943) or by the Bucherer method (Org. Synth. vol. XX, 1940, page 42).

Synthesis Reference(s)

The Journal of Organic Chemistry, 29, p. 1148, 1964 DOI: 10.1021/jo01028a036

reaction suitability

reaction type: solution phase peptide synthesis

Solubility in organics

poorly soluble in alcohol, insoluble in oils.

Purification Methods

Crystallise the acid from aqueous EtOH and dry it at 110o. [Zelinski & Stadnikoff Chem Ber 39 1726 1906, Beilstein

2-Aminoisobutyric Acid Preparation Products And Raw materials

Raw materials

Congo Red Acetone cyanohydrin Alcohol soluble

Preparation Products

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View Lastest Price from 2-Aminoisobutyric Acid manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD
Product
2-Aminoisobutyric Acid 62-57-7
Price
US $0.00/G/KG
Min. Order
1G/KG
Purity
99%
Supply Ability
1000MT
Release date
2025-04-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Aminoisobutyric Acid 62-57-7
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
1000kg
Release date
2021-09-01
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
Aib 62-57-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1T+
Release date
2023-09-15

62-57-7, 2-Aminoisobutyric AcidRelated Search:

α-Amino-hexyl-AMP 1-Aminocyclopropanecarboxylic acid 2-Aminoisobutyric Acid 2,2-Diphenylglycine N-CARBOBENZYLOXY-2-METHYLALANINE,Z-2-METHYLALANINE,Z-ALPHA-METHYLALANINE,N-CARBOBENZYLOXY-2-METHYLALANINE, TECH. DL-ALPHA-METHYLTYROSINE 1-Aminocyclopropane-1-carboxylic acid hydrochloride L-3-(3,4-DIHYDROXYPHENYL)-2-METHYLALANINE,l(-)-beta-(3,4-dihydroxyphenyl)-alpha-methylalanin DL-2-METHYLGLUTAMIC ACID 1-Amino-1-cyclohexanecarboxylic acid ALPHA-METHYL-DL-SERINE Cycloleucine N-METHYL-ALPHA-METHYLALANINE HYDROCHLORIDE dl-3-(3,4-dimethoxyphenyl)-2-hydrazino-2-methylalanine Fmoc-Aib-OH N-ALPHA-METHYL-D-ALANINE HYDROCHLORIDE 2-METHYLALANINE METHYL ESTER HYDROCHLORIDE N,N-BIS(CARBOXYLATOMETHYL)ALANINE TRISODIUM SALT

  • N-ME-ALANINE
  • N-ME-ALA-OH
  • RARECHEM EM WB 0051
  • DL-2-AMINO-ISO-BUTYRIC ACID
  • H-2-AMINOISOBUTYRIC ACID
  • H-ALA(ME)-OH
  • H-AIB-OH
  • H-ALPHA-METHYLALANINE
  • H-(ME)ALA-OH
  • alpha-aminoisobutanoicacid
  • cb1637
  • DL-2-Amino-2-methylpropanoicacid
  • DL-2-Amino-iso-butanoicacid
  • 2-Aminoisobutyric acid;alpha-Aminoisobutyric acid ; 2-Methylalanine; 2-Methylalanine; alpha-Aminoisobutyric acid
  • 2-Aminoisobutyricacid,99%
  • α-Amino-iso-buttersαure
  • 2-Amino-isobutyric acid, 2-Methylalanine
  • α-Aminoisobutyric Acid-13C4
  • Propionic Acid, 2-amino-2-methyl-
  • α-Aminoisobutyric acid, 2-Methylalanine, Aib
  • 2-Methylalanine, Aib
  • 2-amino-2-methylpropionic acid
  • 2-AMINOISOBUTYRIC ACID
  • 2-METHYLALANINE
  • A-AMINO ISO-BUTYRIC ACID
  • AIB
  • ALPHA-AMINOISOBUTYRIC ACID
  • ALPHA-METHYLALANINE
  • 2-Amino-2-methylpropanoic acid
  • 2-amino-2-methylpropanoicacid
  • 2-methyl-alanin
  • Alanine, 2-methyl-
  • Alanine,2-methyl-
  • alpha,alpha-Dimethylglycine
  • 2,2-Dimethylglycine
  • 2-Methyl-2-aminopropionic acid
  • α-Amino-α-methylpropionic acid
  • α-Aminoisobutyric ac
  • 2-AMinoisobutyric acid, 99+% 100GR
  • 2-AMinoisobutyric acid, 99+% 25GR
  • DL-2-Methylalanine
  • α-AMinoisobutyric acid puriss.
  • NSC 16590
  • α-AMinoisobutanoic acid
  • 2-AMinoisobutyric acid 98%
  • 2-AMinoisobutyric acid, 98%+
  • 2-Aminoisobutanoic acid
  • Aib-OH
  • α-Aminoisobutyric acid≥ 99% (Assay)
  • 2-Methylalanine for synthesis
  • L-Aib-OH
  • 2-Aminoisobutyric Acid &gt
  • 2-Amino-2-methylpropionic acid,98%
  • 2-Aminoisobutyric acid C4
  • α-Aminoisobutyric acid
  • 2-Aminoisobutyric Acid USP/EP/BP
  • α,α-Dimethylglycine
  • 2-methylphenylpropionic acid