Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester

Product Name: Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester
CAS No.: 944804-88-0
Chemical Name: Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester
Synonyms: tert-Butyl 4-bromothiazol-2-ylcarbamate;4-Bromo-2-(N-Boc)thiazole;2-(Boc-amino)-4-bromothiazole;tert-Butyl N-(4-bromothiazol-2-yl)carbamate;tert-Butyl (4-bromo-1,3-thiazol-2-yl)carbamate;Tert-butyl N-(4-broMo-1,3-thiazol-2-yl)carbaMate;(4-Bromo-thiazol-2-yl)-carbamic acid tert-butyl ester;Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester
CBNumber: CB21860054
Molecular Formula: C8H11BrN2O2S
Formula Weight: 279.15
MOL File: 944804-88-0.mol

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Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester Property

Density: 1.574±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 4.58±0.70(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C8H11BrN2O2S/c1-8(2,3)13-7(12)11-6-10-5(9)4-14-6/h4H,1-3H3,(H,10,11,12)
InChIKey: OVRIFGLINJVMLO-UHFFFAOYSA-N
SMILES: C(OC(C)(C)C)(=O)NC1=NC(Br)=CS1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Ark Pharm

Product number: P000114259
Product name: tert-Butyl 4-bromothiazol-2-ylcarbamate
Purity: 95+%
Packaging: 100mg
Price: $20
Updated: 2021/12/16

Ark Pharm

Product number: P000114259
Product name: tert-Butyl 4-bromothiazol-2-ylcarbamate
Purity: 95+%
Packaging: 250mg
Price: $32
Updated: 2021/12/16

Ark Pharm

Product number: P000114259
Product name: tert-Butyl 4-bromothiazol-2-ylcarbamate
Purity: 95+%
Packaging: 1g
Price: $96
Updated: 2021/12/16

ChemScene

Product number: CS-M3527
Product name: tert-Butyl(4-bromothiazol-2-yl)carbamate
Purity: 99.40%
Packaging: 1g
Price: $100
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144250
Product name: tert-Butyl (4-bromothiazol-2-yl)carbamate
Packaging: 250mg
Price: $125
Updated: 2021/12/16

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Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester Chemical Properties,Usage,Production

Synthesis

405939-39-1

944804-88-0

General procedure for the synthesis of tert-butyl 4-bromothiazole-2-methylamine from N-BOC-2-amino-5-bromothiazole: diisopropylamine (2.3 mL, 16 mmol) was dissolved in 30 mL of THF at 0 °C. To this solution, 2.5 M hexane solution of butyl lithium (6.4 mL, 16 mmol) was slowly added and the reaction mixture was stirred at the same temperature for 20 min. Subsequently, tert-butyl 5-bromothiazol-2-ylcarbamate (1.5 g, 5.4 mmol) was dissolved in 8 mL of THF and slowly added dropwise to the reaction system. After 15 minutes of reaction, the reaction was quenched by the addition of about 2 mL of water and the mixture was gradually warmed to room temperature with continued stirring for 12 hours. Upon completion of the reaction, the reaction mixture was diluted with 30 mL of 1/2 saturated aqueous NH4Cl and transferred to a dispensing funnel. It was extracted twice with 5 mL EtOAc, and the organic phases were combined, washed with brine and dried over MgSO4. After filtration, the organic phase was concentrated under reduced pressure to give tert-butyl 4-bromothiazol-2-ylcarbamate (1.5 g, 100% yield) as a brown solid.

References

[1] Patent: US2007/173506, 2007, A1. Location in patent: Page/Page column 61; 62
[2] Patent: WO2010/83246, 2010, A1. Location in patent: Page/Page column 123
[3] Patent: US2009/36467, 2009, A1. Location in patent: Page/Page column 64; 72; 73
[4] Patent: US2012/108591, 2012, A1. Location in patent: Page/Page column 29
[5] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 896 - 916

Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester Suppliers

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View Lastest Price from Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester manufacturers

Shanghai Rlavie Technology Co ltd

Product: 2-(Boc-amino)-4-bromothiazole 944804-88-0
Price: US $0.00/KG
Min. Order: 0.0001KG
Purity: 98%min
Supply Ability: 100kgs/month
Release date: 2022-05-10

Career Henan Chemical Co

Product: Carbamic acid, N-(4-bromo-2-thiazolyl)-, 1,1-dimethylethyl ester 944804-88-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2019-12-25

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944804-88-0