ChemicalBook > CAS DataBase List > 1-METHYL-2-INDOLINONE

1-METHYL-2-INDOLINONE

Product Name: 1-METHYL-2-INDOLINONE
CAS No.: 61-70-1
Chemical Name: 1-METHYL-2-INDOLINONE
Synonyms: ba2777;NSC 97219;1-METHYLOXINDOLE;N-METHYLOXINDOLE;1-methyl-oxindol;TIMTEC-BB SBB006878;N-METHYL-2-OXINDOLE;1-Methyl-2-oxindole;1-methyl-2-indolinon;N-methyl-indol-2-one
CBNumber: CB2187248
Molecular Formula: C9H9NO
Formula Weight: 147.17
MOL File: 61-70-1.mol

Less

1-METHYL-2-INDOLINONE Property

Melting point:: 85-88 °C(lit.)
Boiling point:: 110-120 °C(Press: 1 Torr)
Density: 1.167±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: solid
pka: 0.40±0.20(Predicted)
color: White to pink
CAS DataBase Reference: 61-70-1(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
RTECS: NM2208800
HS Code: 2933790090

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 466921
Product name: 1-Methyl-2-oxindole
Purity: 97%
Packaging: 5g
Price: $119.7
Updated: 2025/07/31

TCI Chemical

Product number: M3481
Product name: 1-Methylindolin-2-one
Purity: min. 98.0 %
Packaging: 1G
Price: $65
Updated: 2025/07/31

TCI Chemical

Product number: M3481
Product name: 1-Methylindolin-2-one
Purity: min. 98.0 %
Packaging: 5G
Price: $195
Updated: 2025/07/31

TRC

Product number: M305490
Product name: 1-Methyl-2-oxindole(1-Methyl-2-indolone)
Packaging: 5g
Price: $90
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H48-1-D7
Product name: 1-Methyl-2-oxindole
Purity: 98%
Packaging: 5G
Price: $120
Updated: 2021/12/16

Less

1-METHYL-2-INDOLINONE Chemical Properties,Usage,Production

Chemical Properties

Light-Yellow Solid

Uses

1-Methyl-2-indolone is a reactant for preparation of fluorescent analogues of strigolactones as affectors of parasitic weed germination and fungal branching, irreversible Nek2 Kinase Inhibitors and anticancer agents.

Uses

Reactant for preparation of:

Fluorescent analogues of strigolactones as affectors of parasitic weed germination and fungal branching
Irreversible Nek2 Kinase Inhibitors
Anticancer agents
Antimalarial agents
Antitimor agents
Germination stimulants in plants
Inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1)
Retinoic acid analogs
Potential anti-multiple sclerosis agents
Inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase

Uses

1-Methyl-2-oxindole is used in the prevention and therapy of atherosclerotic degradation of arterial walls.

Synthesis Reference(s)

Journal of the American Chemical Society, 107, p. 435, 1985 DOI: 10.1021/ja00288a027
Journal of Heterocyclic Chemistry, 23, p. 1163, 1986 DOI: 10.1002/jhet.5570230439

Synthesis

59-48-3

77-78-1

61-70-1

To a 5 L four-necked flask (equipped with a mechanical stirrer, condenser tube and nitrogen inlet) was added 2 L of water and 50% sodium hydroxide solution (2.52 mol, 201.6 g, 2.25 eq.) followed by 2-indolone (1.12 mol, 150 g, 1 eq.). The reaction mixture was heated to 40 °C. Dimethyl sulfate (1.68 mol, 211.7 g, 159 mL, 1.5 eq.) was slowly added dropwise via a syringe, the reaction was exothermic during the dropwise addition and the temperature was raised to 53°C. After the dropwise addition, the reaction mixture was heated to 100 °C and maintained for 15 minutes. After the reaction mixture was cooled to 60 °C, the second portion of dimethyl sulfate (0.476 mol, 60 g, 45 mL, 0.425 eq.) was added and the reaction mixture was again heated to 100 °C and maintained for 15 min. The progress of the reaction was monitored by TLC (unfolding agent: heptane/ethyl acetate, 1:1) to confirm that the methylation reaction was essentially complete. The reaction mixture was cooled to 50 °C and the pH was adjusted with concentrated hydrochloric acid to about 7. After inoculation of the crystal seed, the mixture was cooled to room temperature and allowed to stand overnight. The solid product was collected by filtration, washed four times (4×) with water, and subsequently dried under vacuum at 40 °C overnight to afford 1-methyl-2-indolinone 110.7 g (67% yield) as a pink solid with a melting point of 84-86 °C. The reaction was carried out in the presence of a strong hydrochloric acid.

References

[1] Organic Letters, 2012, vol. 14, # 10, p. 2544 - 2547
[2] Tetrahedron Letters, 2015, vol. 56, # 26, p. 3992 - 3995
[3] Chemistry - An Asian Journal, 2017, vol. 12, # 7, p. 734 - 743
[4] Journal of Organic Chemistry, 2010, vol. 75, # 4, p. 1047 - 1060
[5] Tetrahedron Letters, 2001, vol. 42, # 41, p. 7315 - 7317

1-METHYL-2-INDOLINONE Preparation Products And Raw materials

Raw materials

Preparation Products

Less

1-METHYL-2-INDOLINONE Suppliers

Canada 2 China 110 Germany 3 India 1 Russia 1 South Korea 1 Switzerland 1 Ukraine 3 United Kingdom 6 United States 19 Global 147

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Accela ChemBio Co.,Ltd.

Tel: 021-50795510 4000665055
Fax: 021-50795055
Email: sales@accelachem.com
Country: China
ProdList: 11035
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

China DongFan Chemical Co.,LTD

Tel: 86-0571-85151182
Fax: 86-0571-85151182
Country: China
ProdList: 5691
Advantage: 66

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

Chengdu HappySyn Pharmaceutical Technology Co., Ltd.

Tel: 028-85114309 18982182443
Email: yangli@happysyn.com
Country: China
ProdList: 2151
Advantage: 55

Wuhan TCASChem Technology Co., Ltd.

Tel: 027-86697669 13986148687
Fax: 86-027-86697669
Email: sales@tcaschem.com
Country: China
ProdList: 4134
Advantage: 55

Shanghai Topbiochem Technology Co., Ltd

Tel: 021-58170097
Email: info@topbiochem.com
Country: China
ProdList: 9510
Advantage: 58

9ding chemical ( Shanghai) Limited

Tel: 4009209199
Fax: 86-021-52271987
Email: sales@9dingchem.com
Country: China
ProdList: 22514
Advantage: 55

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-6206333 13167063860
Fax: 021-50323701
Email: anhua.mao@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

Shanghai ChriChem Co., Ltd.

Tel: 021-54880687
Fax: 021-54880687
Country: China
ProdList: 511
Advantage: 55

Shanghai JONLN Reagent Co., Ltd.

Tel: 400-0066400 13621662912
Fax: 021-55660885
Email: 422131432@qq.com
Country: China
ProdList: 9979
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Country: China
ProdList: 2930
Advantage: 58

Wuxi Zhongkun Biochemical Technology Co., Ltd.

Tel: 0510-85629785 18013409632
Fax: 051085625359
Email: sales@reading-chemicals.com
Country: China
ProdList: 15178
Advantage: 58

Beijing FYF Chemicals Co., Ltd

Tel: 010-57903446 15869909019
Fax: 010-57903446
Email: 168931144@qq.com
Country: China
ProdList: 2875
Advantage: 58

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Bellen Chemistry Co., Ltd.

Tel: 010-60400365-8001 15910885229
Fax: 010-60400361
Email: service@bellenchem.com
Country: China
ProdList: 4514
Advantage: 60

Codow Chemical Co.,Ltd.

Tel: 18620099427
Fax: +86-20-62619665
Email: amy@howeipharm.com
Country: China
ProdList: 6687
Advantage: 55

Zhengzhou Alfachem Co.,Ltd.

Tel: 0371-53778726 18003825608
Fax: QQ：2885354392
Email: liuxiaoyan@alfachem.cn
Country: China
ProdList: 1986
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Suzhou JingTong Pharmaceutical Co., Ltd.

Tel: 13675155016
Fax: 18912765016
Email: tongtf110@sina.com
Country: China
ProdList: 963
Advantage: 55

Grader reagent

Tel: 18221735425
Email: sales@xinpingchem.com
Country: China
ProdList: 9942
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9125
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Yantai ShengKailun Chemical Technology Co., Ltd.

Tel: 13356901049
Fax: QQ：1025383091
Email: 3119594100@qq.com
Country: China
ProdList: 7964
Advantage: 55

9ding chemical ( Shanghai) Limited

Tel: 021-021-52271985 17721149837
Fax: +86 (21) 52271987
Email: sales@9dingchem.com
Country: China
ProdList: 19800
Advantage: 60

Shanghai Zhen Li Biological Technology Co., Ltd

Tel: 021-16621358918; 18516310516
Fax: 13045646768
Email: zhenlipharma888@163.com
Country: China
ProdList: 19035
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15083
Advantage: 58

Shanghai Haohong Pharmaceutical Co., Ltd.

Tel: 400-8210725 400821072
Fax: 021-58955996
Email: malulu@leyan.com
Country: China
ProdList: 25000
Advantage: 58

Nanjing SynTitan Pharmaceutical Co., Ltd.

Tel: 025-57027686 17372956142
Fax: 025-57027686
Email: li_lan@syntitan.com
Country: China
ProdList: 9998
Advantage: 58

Tianjin heowns Biochemical Technology Co., Ltd.

Tel: 400-6387771-6039 18920764717
Email: sales@heowns.com
Country: China
ProdList: 23771
Advantage: 60

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10295
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52687
Advantage: 58

Guangdong wengjiang Chemical Reagent Co., Ltd.

Tel: 0751-2815688 13927872512
Fax: 0751-8963795
Email: 3007421951@qq.com
Country: China
ProdList: 9939
Advantage: 58

Zhengzhou Alfa Chemical Co.,Ltd

Tel: +8618530059196
Email: sale04@alfachem.cn
Country: China
ProdList: 11784
Advantage: 58

Honest Joy Holdings Limited

Tel: 755-36694831 +8613798234863
Email: Linda.zhou@debayer.com
Country: China
ProdList: 998
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

SIMAGCHEM CORP

Tel: +86-5922680277 +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17346
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Shanghai Boyi Biomedical Technology Co., Ltd.

Tel: 021-021-54331997 18321536537
Email: info@ansionpharma.com
Country: China
ProdList: 2336
Advantage: 58

Yixing Zhongyu Pharmaceutical Technology Co. Ltd.

Tel: 0510-87688158 18761559979
Fax: 0510-87686999
Email: 18761559979@163.com
Country: China
ProdList: 74
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Shanghai Sunway Pharmaceutical Technology Co.,Ltd.

Tel: 021-51816796-820 13611835272
Fax: 021-5161 3951
Email: sales2@sunwaypharm.com
Country: China
ProdList: 44119
Advantage: 58

Less

View Lastest Price from 1-METHYL-2-INDOLINONE manufacturers

Honest Joy Holdings Limited

Product: 1-Methylindolin-2-one 61-70-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.6%
Supply Ability: 100 tons
Release date: 2022-02-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Methyl-2-oxindole 61-70-1
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Chemwill Asia Co.,Ltd.

Product: 1-METHYL-2-INDOLINONE N-Methyl-2-oxindole in stock Factory 61-70-1
Price: US $1.00/kg
Min. Order: 1kg
Purity: High quality purified Factory in China
Supply Ability: Top 3 production capacity Factory
Release date: 2019-04-03

61-70-1, 1-METHYL-2-INDOLINONERelated Search:

1-Methylindole Amedalin N-METHYLISATIN-3-THIOSEMICARBAZONE N-METHYLISATIN 1-PHENYLISATIN 1-(Hydroxymethyl)indoline-2,3-dione 1-METHYL-2-INDOLINONE Lercanidipine Oxindole Nifedipine 4-(3-Nitrophenyl)pyridine AKOS BBS-00001025 1-METHYL-5-NITRO-ISATIN 1-(4-CHLORO-BENZYL)-1H-INDOLE-2,3-DIONE (2,3-DIOXO-2,3-DIHYDRO-INDOL-1-YL)-ACETIC ACID 1-BENZYL-3-(BROMOMETHYL)-3-PHENYLINDOLIN-2-ONE TIMTEC-BB SBB006823 1-(MORPHOLIN-4-YLMETHYL)-1H-INDOLE-2,3-DIONE

2,3-DIHYDRO-1-METHYLINDOL-2-ONE

1-METHYLOXINDOLE

1-METHYL-2-INDOLINONE

1-METHYL-1,3-DIHYDRO-2H-INDOL-2-ONE

TIMTEC-BB SBB006878

N-METHYLOXINDOLE

N-METHYL-2-OXINDOLE

1,3-dihydro-1-methyl-2h-indol-2-on

1,3-dihydro-1-methyl-2h-indol-2-one

1-Methyl-1,3-dihydro-indol-2-one

1-methyl-2-indolinon

1-methyl-oxindol

ba2777

1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl) -3,5-pyridinedicarboxylic acid,monomethylester

1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NTIROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID MONOMET

1,4-DIHYDRO-5-METHOXYCARBONYL-2,6-DIMETHYL-4-(3-NITROPHENYL)PYRIDINE-3-CARBOXYLIC ACID

5-METHOXYCARBONYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDRPYRIDINE-3-CARBOXYLIC ACID(LERCANIDIPINE INTERMEDIATE)

rac-1,4-Dihydro-5-(methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-3-pyridinecarboxylic Aci

2,6-Dimethyl-5-Methoxycarbonyl

2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (intermediate of lercanidine)

2,6-DIMETHYL-5-METHOXYCARBONYL-4-(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3-CARBOXYLIC

1,4-dihydro-2,6-dimethyl-4--(3-nitrophenyl)pyridine-3-carboxylic acid-5-carboxylic methyl ester

1-Methyl-2-indolinone, 1-Methyloxindole

1-Methyl-2-oxindole

1,3-Dihydro-1-methyl-2H-indole-2-one

1-Methyl-2,3-dihydro-1H-indole-2-one

1-methyl-3H-indol-2-one

1-METHYL-2-INDOLINONE N-Methyl-2-oxindole in stock Factory

1-Methylindolin-2-one

N-Methyl-2-indolinone

N-Methylindol-2(3H)-one

NSC 97219

1-Methyl-2-oxindole 97%

1-Methyl-2,3-dihydro-1H-indol-2-one

1,3-Dihydro-1-methyl-2H-indol-2-one, 1-Methylindolin-2-one

2H-Indol-2-one, 1,3-dihydro-1-methyl-

N-methyl-indol-2-one

61-70-1

Building Blocks

Heterocyclic Building Blocks

Indoles

Chemical intermediate for Lercanidipine and Benidipine

Organic acids

(intermediate of lercanidine)

Intermediates & Fine Chemicals

Pharmaceuticals