1-METHYL-2-INDOLINONE
- Product Name
- 1-METHYL-2-INDOLINONE
- CAS No.
- 61-70-1
- Chemical Name
- 1-METHYL-2-INDOLINONE
- Synonyms
- ba2777;NSC 97219;1-METHYLOXINDOLE;N-METHYLOXINDOLE;1-methyl-oxindol;TIMTEC-BB SBB006878;N-METHYL-2-OXINDOLE;1-Methyl-2-oxindole;1-methyl-2-indolinon;N-methyl-indol-2-one
- CBNumber
- CB2187248
- Molecular Formula
- C9H9NO
- Formula Weight
- 147.17
- MOL File
- 61-70-1.mol
1-METHYL-2-INDOLINONE Property
- Melting point:
- 85-88 °C(lit.)
- Boiling point:
- 110-120 °C(Press: 1 Torr)
- Density
- 1.167±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- solid
- pka
- 0.40±0.20(Predicted)
- color
- White to pink
- CAS DataBase Reference
- 61-70-1(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 466921
- Product name
- 1-Methyl-2-oxindole
- Purity
- 97%
- Packaging
- 5g
- Price
- $119.7
- Updated
- 2025/07/31
- Product number
- M3481
- Product name
- 1-Methylindolin-2-one
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $65
- Updated
- 2025/07/31
- Product number
- M3481
- Product name
- 1-Methylindolin-2-one
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $195
- Updated
- 2025/07/31
- Product number
- M305490
- Product name
- 1-Methyl-2-oxindole(1-Methyl-2-indolone)
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- 4H48-1-D7
- Product name
- 1-Methyl-2-oxindole
- Purity
- 98%
- Packaging
- 5G
- Price
- $120
- Updated
- 2021/12/16
1-METHYL-2-INDOLINONE Chemical Properties,Usage,Production
Chemical Properties
Light-Yellow Solid
Uses
1-Methyl-2-indolone is a reactant for preparation of fluorescent analogues of strigolactones as affectors of parasitic weed germination and fungal branching, irreversible Nek2 Kinase Inhibitors and anticancer agents.
Uses
Reactant for preparation of:
- Fluorescent analogues of strigolactones as affectors of parasitic weed germination and fungal branching
- Irreversible Nek2 Kinase Inhibitors
- Anticancer agents
- Antimalarial agents
- Antitimor agents
- Germination stimulants in plants
- Inducers of NAD(P)H-quinone oxidoreductase 1 (NQO1)
- Retinoic acid analogs
- Potential anti-multiple sclerosis agents
- Inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase
Uses
1-Methyl-2-oxindole is used in the prevention and therapy of atherosclerotic degradation of arterial walls.
Synthesis Reference(s)
Journal of the American Chemical Society, 107, p. 435, 1985 DOI: 10.1021/ja00288a027
Journal of Heterocyclic Chemistry, 23, p. 1163, 1986 DOI: 10.1002/jhet.5570230439
Synthesis
59-48-3
77-78-1
61-70-1
To a 5 L four-necked flask (equipped with a mechanical stirrer, condenser tube and nitrogen inlet) was added 2 L of water and 50% sodium hydroxide solution (2.52 mol, 201.6 g, 2.25 eq.) followed by 2-indolone (1.12 mol, 150 g, 1 eq.). The reaction mixture was heated to 40 °C. Dimethyl sulfate (1.68 mol, 211.7 g, 159 mL, 1.5 eq.) was slowly added dropwise via a syringe, the reaction was exothermic during the dropwise addition and the temperature was raised to 53°C. After the dropwise addition, the reaction mixture was heated to 100 °C and maintained for 15 minutes. After the reaction mixture was cooled to 60 °C, the second portion of dimethyl sulfate (0.476 mol, 60 g, 45 mL, 0.425 eq.) was added and the reaction mixture was again heated to 100 °C and maintained for 15 min. The progress of the reaction was monitored by TLC (unfolding agent: heptane/ethyl acetate, 1:1) to confirm that the methylation reaction was essentially complete. The reaction mixture was cooled to 50 °C and the pH was adjusted with concentrated hydrochloric acid to about 7. After inoculation of the crystal seed, the mixture was cooled to room temperature and allowed to stand overnight. The solid product was collected by filtration, washed four times (4×) with water, and subsequently dried under vacuum at 40 °C overnight to afford 1-methyl-2-indolinone 110.7 g (67% yield) as a pink solid with a melting point of 84-86 °C. The reaction was carried out in the presence of a strong hydrochloric acid.
References
[1] Organic Letters, 2012, vol. 14, # 10, p. 2544 - 2547
[2] Tetrahedron Letters, 2015, vol. 56, # 26, p. 3992 - 3995
[3] Chemistry - An Asian Journal, 2017, vol. 12, # 7, p. 734 - 743
[4] Journal of Organic Chemistry, 2010, vol. 75, # 4, p. 1047 - 1060
[5] Tetrahedron Letters, 2001, vol. 42, # 41, p. 7315 - 7317
1-METHYL-2-INDOLINONE Preparation Products And Raw materials
Raw materials
Preparation Products
1-METHYL-2-INDOLINONE Suppliers
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- Ukraine
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View Lastest Price from 1-METHYL-2-INDOLINONE manufacturers
- Product
- 1-Methylindolin-2-one 61-70-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.6%
- Supply Ability
- 100 tons
- Release date
- 2022-02-18
- Product
- 1-Methyl-2-oxindole 61-70-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-METHYL-2-INDOLINONE N-Methyl-2-oxindole in stock Factory 61-70-1
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- High quality purified Factory in China
- Supply Ability
- Top 3 production capacity Factory
- Release date
- 2019-04-03