description Uses Indications and Usage Adverse reactions Contradictions
ChemicalBook > CAS DataBase List > β-Estradiol

β-Estradiol

description Uses Indications and Usage Adverse reactions Contradictions
Product Name
β-Estradiol
CAS No.
50-28-2
Chemical Name
β-Estradiol
Synonyms
Estradiol;17β-estradiol;17β-estradiol;Oestradiol;17beta-Estradiol;Vagifem;Estrogel;17β-Oestradiol;Dihydrofolliculin;BETA-ESTRADIOL-16,16,17-D3
CBNumber
CB2200244
Molecular Formula
C18H24O2
Formula Weight
272.39
MOL File
50-28-2.mol
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β-Estradiol Property

Melting point:
178-179 °C(lit.)
alpha 
D25 +76 to +83° (dioxane)
Boiling point:
355.44°C (rough estimate)
Density 
1.0708 (rough estimate)
refractive index 
80.4 ° (C=1, Dioxane)
Flash point:
2℃
storage temp. 
room temp
solubility 
Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.
pka
pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)
form 
powder
color 
White to off-white
Water Solubility 
Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.
Merck 
14,3703
BRN 
1914275
BCS Class
1
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
VOXZDWNPVJITMN-ZBRFXRBCSA-N
CAS DataBase Reference
50-28-2(CAS DataBase Reference)
NIST Chemistry Reference
Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)
EPA Substance Registry System
Estradiol (50-28-2)
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Safety

Hazard Codes 
T,Xn,F
Risk Statements 
60-61-45-63-64-40-36-20/21/22-11-48
Safety Statements 
53-22-36/37/39-45-36/37-26-16-36-20
RIDADR 
2811
WGK Germany 
3
RTECS 
KG2975000
F 
8-10
HazardClass 
6.1
PackingGroup 
III
HS Code 
29372390
Hazardous Substances Data
50-28-2(Hazardous Substances Data)
Toxicity
LD50 subcutaneous in rat: > 300mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H351Suspected of causing cancer

H362May cause harm to breast-fed children

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E1132
Product name
β-Estradiol
Purity
analytical standard
Packaging
1vial
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
E1132
Product name
β-Estradiol
Purity
analytical standard
Packaging
5vials
Price
$521
Updated
2024/03/01
Sigma-Aldrich
Product number
E-060
Product name
17β-Estradiol solution
Purity
1.0?mg/mL in acetonitrile, ampule of 1?mL, certified reference material, Cerilliant?
Packaging
1mL
Price
$142
Updated
2024/03/01
Sigma-Aldrich
Product number
3301
Product name
17β-Estradiol - CAS 50-28-2 - Calbiochem
Purity
Most potent mammalian estrogenic hormone.
Packaging
1g
Price
$82.8
Updated
2024/03/01
Sigma-Aldrich
Product number
1250008
Product name
Estradiol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$436
Updated
2024/03/01
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β-Estradiol Chemical Properties,Usage,Production

description

β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.
Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

Uses

17β-Estradiol is the major estrogen secreted by the premenopausal ovary.This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
β-Estradiol is used to study cell differentiation and transformations (tumorigenicity).

Indications and Usage

Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.

Adverse reactions

In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.

Contradictions

Do not use on breasts, vaginal area and vaginal mucosa.

Description

Estradiol, 17-beta- is an odorless white to yellow crystalline substance. Molecular weight = 272.42;Boiling point = (decomposes); Freezing/Meltingpoint = 173 - 179℃. Hazard Identification (based onNFPA-704 M Rating System): Health 2, Flammability 1,Reactivity 0. Insoluble in water.

Chemical Properties

White or almost white, crystalline powder or colourless crystals.

Chemical Properties

Estradiol, 17-β-is an odorless white to yellow crystalline substance.

Uses

17β-Estradiol is the major estrogen secreted by the premenopausal ovary.This compound is a contaminant of emerging concern (CECs). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.

Uses

Estradiol USP (Estrace) is used to treat Breast cancer; prostatic carcinoma.

Application

β-Estradiol has been used:
for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)
as a supplement in in vitro maturation medium (IVM), which is used as a control medium
in estrogen-induction assay

Definition

ChEBI: The 17beta-isomer of estradiol.

Acquired resistance

Estradiol is the most potent endogenous estrogen, exhibiting high affinity for the ER and high potency when administered parenterally. When administered orally, estradiol is promptly conjugated in the intestine and oxidatively metabolized by the liver, resulting in its low oral bioavailability and therapeutic effectiveness.

General Description

Estradiol, estra-1,3,5(10)-triene-3,17β-diol, is the most activeof the natural steroid estrogens. Although its 17β-OHgroup is vulnerable to bacterial and enzymatic oxidation toestrone, it can be temporarily protected as anester at C3 or C17, or permanently protected by adding a17α-alkyl group (e.g., 17α-ethinyl estradiol, the most commonlyused estrogen in oral contraceptives). The increasedoil solubility of the 17β-esters (relative to estradiol) permitsthe esters to remain in oil at the IM injection site for extendedperiods. These derivatives illustrate the principles of steroidmodification. Transdermal estradiolproducts avoid first-pass metabolism, allowing estradiol tobe as effective as oral estrogens for treating menopausalsymptoms. A new transdermal spray, Evamist, was approvedin 2007. Estradiol itself is typically not very effective orallybecause of rapid metabolism, but an oral formulation of micronizedestradiol that allows more rapid absorption of thedrug is available (Estrace). In addition to the oral and transdermalproducts, estradiol is also available in gel, cream, andvaginal ring formulations. The commercially available estradiolesters are the following:
Estradiol 3-acetate, USP (oral; vaginal ring)
Estradiol 17-valerate, USP (IM injection)
Estradiol 17-cypionate, USP (IM injection).

Hazard

A carcinogen (OSHA).

Biological Activity

Endogenous estrogen receptor (ER) agonist (K i values are 0.12 and 0.13 nM for ER α and ER β respectively). Also high affinity ligand at membrane estrogen GPR30 receptors.

Contact allergens

Natural estradiol, used in transdermal systems for hormonal substitution, can induce allergic contact dermatitis, with the risk of systemic contact dermatitis after oral reintroduction.

Biochem/physiol Actions

The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.

Mechanism of action

The most potent naturally occurring estrogen in mammals. It is synthesized primarily in the ovary, and also in the testis, adrenal gland and placenta, and to a limited extent by peripheral tissues (e.g., liver, fat, and skeletal muscle) from androstenedione and testosterone. It is responsible for the development of secondary sex characteristics in the female at puberty (i.e., growth and development of the vagina, uterus and fallopian tubes, enlargement of the breasts, and growth and maturation of long bones).

Safety Profile

Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. A promoter. Human reproductive effects by ingestion: ferthty effects. Experimental reproductive effects. Human mutation data reported. A steroid hormone much used in medicine. When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

Estradiol, estra-1,3,5(10)-trien-3,17|?-diol (28.1.17), is most easily made by reducing the keto-group of estrone by various reducing agents, in particular potassium borohydride.

Potential Exposure

The working environment may be contaminated during sex hormone manufacture, especially during the extraction and purification of natural steroid hormones; grinding of raw materials; handling of powdered products and recrystallization. Airborne particles of sex hormones may be absorbed through the skin, ingested or inhaled. Enteric absorption results in quick inactivation of sex hormones in the liver. The rate of inactivation is decreased for the oral, alkylated steroid hormones (methyl testosterone, anabolic steroids, etc.). Sex hormones may accumulate and reach relatively high levels even if their absorption is intermittent. Consequently, repeated absorption of small amounts may be detrimental to health. Intoxication by sex hormones may occur in almost all the exposed workers if preventive measures are not taken. The effect in the industrial sector is more successful than the agricultural one (chemical caponizing of cockerels by stilbestrol implants and incorporation of estrogens in feed for body weight gain promotion in beef cattle), where measures taken are summary and the number of cases of intoxication is consequently bigger

First aid

If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.

storage

Room temperature

Shipping

UN3249 Medicine, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials

Purification Methods

17-Estradiol (previously known as -estradiol) is purified by chromatography on SiO2 (toluene/EtOAc 4:1) and recrystallised from CHCl3/hexane or 80% EtOH. It is stable in air, is insoluble in H2O, and is precipitated by digitonin. The UV has max at 225 and 280 nm. The diacetate [3434-88-6] has m 97-98o and forms leaflets from aqueous EtOH. The 3-benzoate crystallises from aqueous MeOH withm 193o and [] D 25 +58o to 63o (c 1, dioxane). [Meischer & Scholz Helv Chim Acta 20 263, 1237 1937, Biochem J 32 1273 1938, Oppolzer & Roberts Helv Chim Acta 63 1703 1980, Inhoffen & Zühlsdorff Chem Ber 7 4 1914 1941, Beilstein 6 IV 6611.]

β-Estradiol Preparation Products And Raw materials

Raw materials

p-Toluenesulfonic acid ADD 3# ketone Nitrogen Biphenyl Diphenylmethane Estrone Dibromo Acetylacetone Potassium borohydride 4-ETHYL-2-METHYLPYRIDINE Lithium

Preparation Products

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View Lastest Price from β-Estradiol manufacturers

Dorne Chemical Technology co. LTD
Product
β-ESTRADIOL Estradiol 50-28-2
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20 tons
Release date
2024-03-26
Jinan Million Pharmaceutical Co., Ltd
Product
β-Estradiol 50-28-2
Price
US $6.00/kg
Min. Order
0.1kg
Purity
99.45
Supply Ability
60 tons
Release date
2024-09-24
CONTIDE BIOTECH CO.,LTD
Product
Estradiol 50-28-2
Price
US $0.00/G
Min. Order
1G
Purity
99%
Supply Ability
20
Release date
2024-04-12

50-28-2, β-EstradiolRelated Search:

Estriol Hydrocortisone Motolimod ESTRADIOL, 17B-,CIS-ESTRADIOL,B-ESTRADIOL,BETA-ESTRADIOL BETA-ESTRADIOL 17-VALERATE B-ESTRADIOL-3-BENZOATE,BETA-ESTRADIOL BENZOATE,BETA-ESTRADIOL 3-BENZOATE BETA-ESTRADIOL-17-ENANTHATE Ethynyl estradiol ESTRIOL TRISULFATE TRISODIUM SALT 17a-Ethynyl-1,3,5(10)-estratriene-3,17b-diol 3-methyl ether Quinestrol Estradiol Cypionate Acid Red 94 Inositol 1,3,5[10]-ESTRATRIENE-3,16ALPHA,17BETA-TRIOL 3-GLUCURONIDE SODIUM SALT ESTRIOL TRIACETATE BETA-ESTRADIOL 3-METHYL ETHER 2-HYDROXYESTRADIOL Oestradiol

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  • 13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
  • ESTRADIOL, 17B-(RG)
  • ESTRADIOL(17-BETA-ESTRADIOL)
  • 17B-OESTRADIOL
  • ESTRADIOL-17
  • SS-ESTRADIOL