ChemicalBook > CAS DataBase List > Homosalate

Homosalate

Product Name: Homosalate
CAS No.: 118-56-9
Chemical Name: Homosalate
Synonyms: HMS;HOMOMENTHYL SALICYLATE;Heliopan;3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE;Benzoicacid,2-hydroxy-,3,3,5-trimethylcyclohexylester;Homosalat;HELIOPHAN;omosalate;Coppertone;HOMOSALATE
CBNumber: CB2203124
Molecular Formula: C16H22O3
Formula Weight: 262.34
MOL File: 118-56-9.mol

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Homosalate Property

Boiling point:: 161-165°C (12 torr)
Density: 1.05
vapor pressure: 0.015Pa at 25℃
refractive index: n20 1.516 to 1.518
Flash point:: 169 - 173℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly)
pka: 8.10±0.30(Predicted)
form: Liquid
color: Colourless
Odor: at 100.00?%. mild menthol
Water Solubility: <0.1 g/100 mL at 26 ºC
BRN: 2731604
LogP: 6.27 at 25℃
CAS DataBase Reference: 118-56-9(CAS DataBase Reference)
NIST Chemistry Reference: Homosalate(118-56-9)
EPA Substance Registry System: 3,3,5-Trimethylcyclohexyl salicylate (118-56-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36/39
WGK Germany: 2
HS Code: 29182300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR1085
Product name: Homosalate
Purity: Pharmaceutical Secondary Standard; Certified Reference Material
Packaging: 1g
Price: $101
Updated: 2025/07/31

Sigma-Aldrich

Product number: S356662
Product name: 3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE
Purity: AldrichCPR
Packaging: 1 unit
Price: $179
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1311408
Product name: Homosalate
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 500mg
Price: $393
Updated: 2025/07/31

TCI Chemical

Product number: T2278
Product name: 3,3,5-Trimethylcyclohexyl Salicylate (cis- and trans- mixture)
Purity: >98.0%(GC)
Packaging: 25g
Price: $48
Updated: 2025/07/31

TCI Chemical

Product number: T2278
Product name: 3,3,5-Trimethylcyclohexyl Salicylate (cis- and trans- mixture)
Purity: >98.0%(GC)
Packaging: 100g
Price: $118
Updated: 2025/07/31

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Homosalate Chemical Properties,Usage,Production

Description

Homosalate is an organic compound that belongs to a class of chemicals called salicylates. Salicylates prevent direct skin exposure to the sun’s harmful rays by absorbing ultraviolet (UV) light. Homosalate specifically absorbs short-wave UVB rays, associated with DNA damage and an increased risk of skin cancer. It is a widely used chemical in sunscreens and skin care products with SPF. However, Homosalate is a potential endocrine disruptor and studies in cells suggest it may impact hormones. In addition to direct health concerns following homosalate exposure, the chemical may also enhance the absorption of pesticides in the body.

Chemical Properties

Liquid.

Uses

Homosalate used as a UV filter in various personal skin care formulations and cosmetics.

Uses

UV screen, analgesic

Uses

homosalate is a chemical uVB absorber included in the FDA’s Category I Sunscreen Chemical list. Its approved usage level is 4 to 15 percent by the FDA and 10 percent by the european union’s Cosmetic Directive.

Definition

A homolog of menthyl salicylate.

brand name

Eusolex (Rona Laboratories, Great Britain); Heliophan (Greeff).

General Description

Viscous or light yellow to slightly tan liquid or oil.

Air & Water Reactions

Homosalate will hydrolyze under basic conditions. . Insoluble in water.

Reactivity Profile

An ester and a phenol. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.

Fire Hazard

Homosalate is probably combustible.

Flammability and Explosibility

Non flammable

Side effects

Similar to oxybenzone, homosalate affects hormone activity once absorbed. Skin rashes, acne and skin irritation are rare side effects of the toxic chemical. Estrogen, androgen and progesterone have all been found to be disrupted when the body is exposed to homosalate.

Synthesis

116-02-9

119-36-8

118-56-9

In a 250 mL three-necked flask, 10.0 g of methyl salicylate and 23.3 g of 3,3,5-trimethylcyclohexanol were added as reaction feedstock, followed by 0.50 g of potassium carbonate as a catalyst and 0.1 g of ammonium bromide as a co-catalyst. The reaction mixture was heated to 180 °C and the reaction was continued at this temperature for 13 hours. The conversion of methyl salicylate was monitored by gas chromatography during the reaction. Upon completion of the reaction, the products were separated using a vacuum distillation unit, and the fore grade fractions were recycled. Finally, 13.98 g of 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate was obtained as a colorless liquid with a yield of 81.1%, and the purity was analyzed by gas chromatography to be greater than 99%.

References

[1] Patent: CN105541634, 2016, A. Location in patent: Paragraph 0023; 0024

Homosalate Preparation Products And Raw materials

Raw materials

Preparation Products

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Homosalate Suppliers

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View Lastest Price from Homosalate manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: Homosalate 118-56-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 10000KGS
Release date: 2025-07-04

Anhuyan (Hainan) Biotechnology Co., LTD

Product: Homosalate 118-56-9
Price: US $0.00-0.00/kg
Min. Order: 0.001kg
Purity: 99%
Supply Ability: 2000000T
Release date: 2025-06-11

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Homosalate 118-56-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 30tons/month
Release date: 2023-01-11

118-56-9, HomosalateRelated Search:

N,N-Dimethylcyclohexylamine Dimethylbenzylcarbinyl acetate Sodium salicylate 3-Methylsalicylic acid Benzyldimethylcarbinyl butyrate Cyclohexanol 2-Methyl-2-propenoic acid cyclohexyl ester Phenyl salicylate Isoamyl o-hydroxybenzoate Methyl salicylate TRILAURIN Triisopropyl orthoformate ORTHO-N-VALERIC ACID TRIETHYL ESTER Triethyl orthoformate Tetraethyl orthocarbonate Trimethoxymethane Triethyl orthoacetate ptaquiloside

Benzoic acid, 2-hydroxy-, 3,3,5-trimethylcyclohexyl ester

Benzoicacid,2-hydroxy-,3,3,5-trimethylcyclohexylester

component of Coppertone

Coppertone

Filtersol ''A''

Filtrosol A

Heliopan

Homosalat

Kemester HMS

m-Homomenthyl salicylate

Salicylicacid,m-homomenthylester

HELIOPHAN

EUSOLEX(R) HMS

HMS

HOMOSALATE

HOMOMENTHYLE SALICYLATE

HOMOMENTHYL SALICYLATE

SALICYLIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER

trimethylcyclohenyl salicylate

2-HYDROXYBENZOIC ACID 3,3,5-TRIMETHYLCYCLOHEXYL ESTER

3,3,5-TRIMETHYLCYCLOHEXYL 2-HYDROXYBENZOATE

3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE

Homosalate (HMS)

3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE 98+% T

3,3,5-Trimethylcyclohexyl Salicylate (cis- and trans- mixture)

Filtrosal A

Salicylic acid 3,3,5-trimethylcyclohexyl

Homosalate (500 mg)

Homosalate (500 mg)H0D3220.994mg/mg(ai)

HoMosalate, USP

2-Hydroxybenzoic Acid 3,3,5-Trimethylcyclohexyl Ester Salicylic Acid 3,3,5-Trimethylcyclohexyl Ester 3,3,5-Trimethylcyclohexyl 2-Hydroxybenzoate

3,3,5-TriMethylcyclohexyl salicylate, Mixture of cis and trans

3.3.5-TriMethy

3,3,5-Trimethylcyclohexyl salicylate(cis-and trans- mixture)

Sunsafe-HMS

3,3,5-Trimethylcyclohexyl salicylate, 98%, mixture of cis and trans

uv absorber HMS(HOMOSALATE)

3,3,5-TRIMETHYLCYCLOHEXYL SALICYLATE Homosalate

omosalate

Homosalate (HMS)@100 μg/mL in Acetonitrile

UV ABSORBER TRUELICHT HMS

Sunsafe-HMS / Homosalate

Sunscreen Homosalate

UV Absorber HMS

Mfsorb? Colomate

Dsunpro Hms

HOMO METHYL SALICYLATE

Homosalate in methanol

C17881300 3,3,5-TrimethylcyclohexyLsalicylat

Homosalate, 10 mM in DMSO

118-56-9

ALCOHOL

EUSOLEX