ARGIPRESSIN ACETATE
- Product Name
- ARGIPRESSIN ACETATE
- CAS No.
- 129979-57-3
- Chemical Name
- ARGIPRESSIN ACETATE
- Synonyms
- AVP;AC-AVP;AC[ARG8]VASOPRESSIN;ARGIPRESSIN ACETATE;Argipressine acetate;[Arg8]Vasopressin TFA;Acetate fine vasopressin;[Arg8]Vasopressin acetate;[8-ARG]VASOPRESSIN ACETATE;BETA-HYPOPHAMINE ACETATE SALT
- CBNumber
- CB2205623
- Molecular Formula
- C48H69N15O14S2
- Formula Weight
- 1144.28
- MOL File
- 129979-57-3.mol
ARGIPRESSIN ACETATE Property
- Melting point:
- 189 °C(dec.)
- storage temp.
- −20°C
- solubility
- Water: 1 mg/ml
- form
- powder to crystal
- color
- White to Light yellow
- Water Solubility
- Water: 1 mg/ml
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- V0159
- Product name
- [Arg 8]-Vasopressin Acetate
- Packaging
- 5MG
- Price
- $178
- Updated
- 2025/07/31
- Product number
- V0159
- Product name
- [Arg 8]-Vasopressin Acetate
- Packaging
- 25MG
- Price
- $536
- Updated
- 2025/07/31
- Product number
- 24154
- Product name
- Argipressin (acetate)
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $68
- Updated
- 2024/03/01
- Product number
- 354139
- Product name
- AVP
- Packaging
- 48Tests
- Price
- $588
- Updated
- 2021/12/16
- Product number
- 38359
- Product name
- [Arg8]-Vasopressinacetate,98%(HPLC)
- Purity
- 98%(HPLC)
- Packaging
- 25MG
- Price
- $1058.4
- Updated
- 2021/12/16
ARGIPRESSIN ACETATE Chemical Properties,Usage,Production
Description
Argipressin is a peptide hormone with vasoconstrictive and antidiuretic activities that binds to the vascular arginine vasopressin receptor, V1, with Kd values of 1.31 and 1.44 nM in A7r5 rat aortic smooth muscle cells and neonatal rat cardiomyocytes, respectively. It also stimulates the intracellular release of calcium in A7r5 cells (EC50 = 5 nM). In rat models, argipressin induces hypertension and tachycardia when injected into the lateral septal nuclei at a dose of 100-400 ng and increases heart rate and mean arterial pressure (MAP) when injected into the medial amygdaloid body at a dose of 150-600 ng.
Uses
Argipressin (Arg8-vasopressin) (acetate) binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1[1][2][3][4].
in vivo
Argipressin (Arg8-vasopressin) (acetate) (25 nmol/kg bw; intraperitoneal injection; once) significantly reduces overall AUC glucose values, but not increases insulin levels in mice[1].
| Animal Model: | NIH Swiss mice (adult; male; 12-14weeks)[1] |
| Dosage: | 25 nmol/kg bw |
| Administration: | AVP (25 nmol/kg bw; intraperitoneal injection; once) |
| Result: | Reduced (P<0.001) overall AUC glucose values，but not increased insulin levels in mice. |
References
[1] Shruti Mohan, et al. Vasopressin receptors in islets enhance glucose tolerance, pancreatic beta-cell secretory function, proliferation and survival. Biochimie. DOI:10.1016/j.biochi.2019.01.008
[2] Thibonnier M, et al. Multiple signaling pathways of V1-vascular vasopressin receptors of A7r5 cells. Endocrinology. 1991 Dec;129(6):2845-56. DOI:10.1210/endo-129-6-2845
[3] Moriya T, et al. Vasopressin-induced intracellular Ca2? concentration responses in non-neuronal cells of the rat dorsal root ganglion. Brain Res. 2012 Nov 5;1483:1-12. DOI:10.1016/j.brainres.2012.08.028
[4] Keun Suk Park, et al. Role of vasopressin in current anesthetic practice. Korean J Anesthesiol. 2017 Jun; 70(3): 245–257. DOI:10.4097/kjae.2017.70.3.245
ARGIPRESSIN ACETATE Preparation Products And Raw materials
Raw materials
Preparation Products
ARGIPRESSIN ACETATE Suppliers
- Tel
- --
- Fax
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- sales-in@tcichemicals.com
- Country
- India
- ProdList
- 6768
- Advantage
- 58