Cinobufagin

Description References

Product Name: Cinobufagin
CAS No.: 470-37-1
Chemical Name: Cinobufagin
Synonyms: FEMA 2288;AKOS 233-01;CINOBUFAGIN;16-beta)-bet;cinobufagine;AKOS B004228;CINOBUFAGIN(P);Cinobufagin-RM;Cinobufagin std.;Cinobufagin (6CI)
CBNumber: CB2206701
Molecular Formula: C26H34O6
Formula Weight: 442.55
MOL File: 470-37-1.mol

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Cinobufagin Property

Melting point:: 133 °C(lit.)
Boiling point:: 300 °C(lit.)
Density: 1.261 g/cm3
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
pka: 15.10±0.70(Predicted)
form: powder to crystal
color: White to Light yellow

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Safety

Hazard Codes: Xi,T+,Xn
Risk Statements: 36/37/38-26/27/28-42/43-20/22
Safety Statements: 26-36-45-36/37/39-22-24/25
RIDADR: UN 2811 6.1/PG 1
WGK Germany: 3
RTECS: GD7850000
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29322090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H310Fatal in contact with skin

H330Fatal if inhaled

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P284Wear respiratory protection.

P302+P350IF ON SKIN: Gently wash with plenty of soap and water.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3460
Product name: Cinobufagine
Purity: >98.0%(HPLC)
Packaging: 25mg
Price: $304
Updated: 2024/03/01

TCI Chemical

Product number: C3460
Product name: Cinobufagine
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $908
Updated: 2024/03/01

Cayman Chemical

Product number: 19844
Product name: Cinobufagin
Packaging: 5mg
Price: $115
Updated: 2024/03/01

Cayman Chemical

Product number: 19844
Product name: Cinobufagin
Packaging: 50mg
Price: $566
Updated: 2024/03/01

Cayman Chemical

Product number: 19844
Product name: Cinobufagin
Packaging: 10mg
Price: $206
Updated: 2024/03/01

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Cinobufagin Chemical Properties,Usage,Production

Description

Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.

References

1. https://en.wikipedia.org/wiki/Cinobufagin
2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412
3. http://www.yourdictionary.com/cinobufagin
4. https://www.medchemexpress.com/cinobufagin.html

Description

Cinobufagin is a cardiotonic steroid that has been found in the skin of toads of genus Bufo and has diverse biological activities. It inhibits Na⁺/K⁺-ATPase activity in guinea pig heart ventricular muscle homogenates by 45% when used at a concentration of 0.3 μM. Cinobufagin is cytotoxic to HCT116 colorectal cancer cells in vitro with IC₅₀ values of less than 50 ng/ml at 48- and 72-hour time points and induces apoptosis in a concentration-dependent manner. In vivo, cinobufagin (10 mg/kg) reduces tumor growth in an HCT116 mouse xenograft model. Cinobufagin (1 μg/ml) inhibits LPS-induced expression of MHC class II, CD80, and CD86 and release of IL-6, IL-8, TNF-α, and IL-10 in human monocyte-derived dendritic cells. It also increases expression of the antimicrobial peptides hBD2 and hBD3 in dendritic cells. Cinobufagin exhibits dose-dependent antinociceptive effects in the hot-plate, acetic acid writhing, and formalin tests in mice.

Uses

Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects.

Definition

ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide.

Cinobufagin Preparation Products And Raw materials

Raw materials

Preparation Products

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Cinobufagin Suppliers

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View Lastest Price from Cinobufagin manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Cinobufagin 470-37-1
Price: US $1.00-100.00/KG
Min. Order: 1KG
Purity: 95%
Supply Ability: 300KG
Release date: 2024-07-26

Shanghai Standard Technology Co., Ltd.

Product: Cinobufagin 470-37-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: Analytical Standard
Supply Ability: 10 g
Release date: 2019-10-10

Shanghai Standard Technology Co., Ltd.

Product: Cinobufagin 470-37-1
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-10-10

470-37-1, CinobufaginRelated Search:

Cellulose acetate Ammonium acetate Glatiramer acetate Vinyl acetate POLY(VINYL ACETATE) Sodium acetate Ethyl acetate CIS-2,3-EPOXYBUTANE (S)-1,2-EPOXYOCTANE 1,2-EPOXY-5-HEXENE Resibufogenin 7-OCTEN-2-OL, 2-METHYL-6-METHYLENE TRANS-2,3-EPOXYBUTANE 1,2-EPOXY-9-DECENE Isopentyl ether FEMA 2348 (S)-(+)-Methyl glycidyl ether ACETATE

RARECHEM BK HC T302

5b,20(22)-Bufadienolide-3b,16b-diol-14,15b-epoxy 16-acetate

CINOBUFAGIN95%,99%

CINOBUFAGIN(P)

TRANS-3-PHENYLPROPENOIC ACID

TRANS-3-BENZENEPROPENOIC ACID

TRANS-CINNAMYLIC ACID

Cinobufagin std.

16β-Acetoxy-14,15β-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide

16β-Acetyloxy-14,15β-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide

14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate

5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate

5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate, 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate

Cinobufogenin，Cinobufagin

5-((1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-2-Acetyl-7-hydroxy-9a,11a-diMethylhexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-1-yl)-2H-pyran-2-one

Cinobufagin, 98%, from cinobufagin venom toad

16-beta)-bet

22-dienolide,16-(acetyloxy)-14,15-epoxy-3-hydroxy-,(3-beta,5-beta,15-bufa-2

cinobufagine

AKOS B004228

AKOS 233-01

3-STYRYLACRYLIC ACID

3-PHENYLACRYLIC ACID

5BETA,20[22]-BUFADIENOLIDE-3BETA,16BETA-DIOL-14,15BETA-EPOXY 16-ACETATE

2-PROPENOIC ACID, 3-PHENYL-, (2E)-

14,15BETA-EPOXY-3BETA,16BETA-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE 16-ACETATE

BETA-PHENYLACRYLIC ACID

FEMA 2288

CINNAMIC ACID, TRANS-

CINOBUFAGIN

cinobufagin venom toad

Bufa-20,22-dienolide, 16-(acetyloxy)-14,15-epoxy-3-hydroxy-, (3β,5β,15β,16β)-

Cinobufagin (Cinobufagine)

Cinobufagin (6CI)

(1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-Hydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate

Chinese bufotoxin

(1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-7-Hydroxy-9a,11a-dimethyl-1-(2-oxo-2H-pyran-5-yl)hexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-2-yl acetate

Cinobufagin-RM

470-37-1

C26H34O6

C26H34O6nH2O

Proteomics and Protein Expression

Protein Analysis

Organic Building Blocks

Matrices for MALDI Analysis

Auxins

Mass Spectrometry

Matrix Materials (MALDI-TOF-MS)

Plant Growth Regulators

BioChemical

Building Blocks

C9

Carbonyl Compounds

Carboxylic Acids

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).