ChemicalBook > CAS DataBase List > (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride

Product Name
(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
CAS No.
300576-59-4
Chemical Name
(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
Synonyms
(+/-)-PD 128;(+)PD 128907;(+)-PD 128970 HCl;(+)-PD 128907 HCl;(+)-PD 128907 HCl, >=98%;(+)-PD 128907 HYDROCHLORIDE;(+/-)-PD 128,907 HYDROCHLORIDE;(+)-PD 128907 hydrochloride, 10 mM in DMSO;(4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol;(4aR,10bR)-4-propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol hydrochloride
CBNumber
CB22129471
Molecular Formula
C14H19NO3HCl
Formula Weight
285.77
MOL File
300576-59-4.mol
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(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Property

storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
ethanol: >10mg/mL
form 
solid
color 
off-white
Water Solubility 
Soluble to 10 mM in water
InChIKey
DCFXOTRONMKUJB-QMDUSEKHSA-N
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Safety

Safety Statements 
24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P183
Product name
(+)-PD 128,907 hydrochloride
Purity
>97%, solid
Packaging
5mg
Price
$601
Updated
2023/01/07
Sigma-Aldrich
Product number
P183
Product name
(+)-PD 128,907 hydrochloride
Purity
>97%, solid
Packaging
25mg
Price
$2100
Updated
2022/05/15
Cayman Chemical
Product number
21235
Product name
(+)-PD 128907 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21235
Product name
(+)-PD 128907 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
21235
Product name
(+)-PD 128907 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$214
Updated
2024/03/01
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(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Chemical Properties,Usage,Production

Uses

(+)-PD 128907 Hydrochloride is a potent D3 receptor agonist.

Biological Activity

Potent D 3 dopamine receptor agonist (K i = 2.3 nM). Displays 18-200-fold selectivity over other dopamine receptor subtypes.

in vivo

(+)-PD 128907 significantly decreases dialysate DA levels in D3 knock out mice. The IC25 values are 61 nM and 1327 nM, respectively, for wild type and D3knock out mice. The ratio of the IC25 values shows that (+)-PD 128907 is 22 times more potent in decreasing dialysate DA levels in wild type as compared to mice lacking the D3 receptor. The D3 agonist evokes a dose related decrease in dialysate DA in wild type mice. Post-hoc analysis shows that all doses tested (0.03, 0.1 and 0.3 mg/kg) significantly inhibit dialysate DA. The IC25 values are 0.05 and 0.44 mg/kg for wild type and knock out mice, respectively, indicating that systemically administered (+)-PD 128907 is 9 times more potent in decreasing dialysate DA in the ventral striatum of wild type as compared to D3 knock out mice. Doses of 1 mg/kg or higher of (+)-PD 128907 markedly inhibits dialysate DA in both wild type and D3 knock out mice[3].

IC 50

D3 Receptor; D2 Receptor

storage

Store at +4°C

(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride Suppliers

China 61 India 1 The Netherlands 1 United Kingdom 2 United States 9 USA 1 Global 75
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300576-59-4, (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochlorideRelated Search:

(1R,2R)-(-)-2-Amino-1-phenyl-1,3-propanediol (-)-Pseudoephedrine Phenylephrine hydrochloride Phenylephrine DL-PHENYLEPHRINE HYDROCHLORIDE DL-Methylephedrine hydrochloride (R)-2-Methyl-morpholine Phenmetrazine (R)-(-)-2-AMINO-1-PHENYLETHANOL HCL (R*,R*)-alpha-(1-aminoethyl)benzyl alcohol (±)-alpha-[(ethylamino)methyl]-m-hydroxybenzyl alcohol (+)-(4aR,10bR)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride 3(R)-HYDROXYMETHYLMORPHOLINE N-ETHYL-2-METHOXY-BENZENEETHANAMINE 2-(2-aminopropyl)phenol (+)-PD 128907 HYDROCHLORIDE CHEMBRDG-BB 5740188 2-[(1-methyl-2-phenoxyethyl)amino]ethanol

  • (+/-)-PD 128,907 HYDROCHLORIDE
  • (+)-PD 128907 HYDROCHLORIDE
  • (+)-(4ar,10br)-3,4,4a,10b-tetrahydro-4-propyl-2h,5h-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride
  • (S)-(+)-(4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-ol hydrochloride
  • (4aR,10bR)-3,4a,4,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano-[4,3-b]-1,4-oxazin-9-olhydrochloride
  • (4aR,10bR)-4-propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol hydrochloride
  • (4aR,10bR)-rel-4-Propyl-2,3,4,4a,5,10b-hexahydrochroMeno[4,3-b][1,4]oxazin-9-ol
  • (+/-)-PD 128
  • (+)-PD 128907 HCl, >=98%
  • (+)-PD 128970 HCl
  • (4aR,10bR)-4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol, hydrochloride
  • (4aR,10aR)-1-Propyl-2,3,10,10a-tetrahydro-1H,4aH-4,9-dioxa-1-azaphenanthren-6-ol hydrochloride
  • (4aR,10bR)-4-Propyl-3,4,4a,10b-tetrahydro-2H,5H-chromeno[4,3-b][1,4]oxazin-9-ol hydrochloride
  • (+)-PD 128907,Dopamine Receptor,inhibit,(+) PD 128907 hydrochloride,Inhibitor,(+)PD 128907 hydrochloride
  • (+)PD 128907
  • (+)-PD 128907 HCl
  • (+)-PD 128907 hydrochloride, 10 mM in DMSO
  • 300576-59-4
  • Dopamine receptor