ChemicalBook > CAS DataBase List > 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran

8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran

Product Name
8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
CAS No.
150821-03-7
Chemical Name
8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
Synonyms
PRANLUKASTHEMIHYDRATE;Pranlukast hemihydrate >=98% (HPLC), white solid;N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phe...;8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran;N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide,hydrate;N-[4-oxo-2-(1H-1,2,3,4-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide hydrate;N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide hemihydrate;Benzamide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-,hydrate (2:1);Pranlukast hydrateQ: What is Pranlukast hydrate Q: What is the CAS Number of Pranlukast hydrate Q: What is the storage condition of Pranlukast hydrate
CBNumber
CB22130178
Molecular Formula
C27H25N5O5
Formula Weight
499.53
MOL File
150821-03-7.mol
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8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Property

storage temp. 
-20°C
solubility 
DMSO: ≥10mg/mL
form 
white solid
color 
White to off-white
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36/37
WGK Germany 
3
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0080
Product name
Pranlukast hemihydrate
Purity
≥98% (HPLC), white solid
Packaging
5mg
Price
$152
Updated
2025/07/31
Sigma-Aldrich
Product number
P0080
Product name
Pranlukast hemihydrate
Purity
≥98% (HPLC), white solid
Packaging
25mg
Price
$597
Updated
2025/07/31
ChemScene
Product number
CS-5992
Product name
Pranlukast hemihydrate
Purity
99.93%
Packaging
50mg
Price
$72
Updated
2021/12/16
ChemScene
Product number
CS-5992
Product name
Pranlukast hemihydrate
Purity
99.93%
Packaging
100mg
Price
$121
Updated
2021/12/16
Matrix Scientific
Product number
047904
Product name
Pranlukast hemihydrate
Purity
>95%
Packaging
500mg
Price
$625
Updated
2021/12/16
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8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Chemical Properties,Usage,Production

Uses

Pranlukast hemihydrate is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

Biochem/physiol Actions

Pranlukast is a subtype specific CysLT1 receptor antagonist. Leukotrienes are involved in the inflammation response and are divided into two main classes; leukotriene B4 and cysteinyl-substituted leukotrienes.

in vivo

Carrageenan (CAR, 5 mg per mouse) is injected i.p. 24 h before LPS (50 p,g per mouse) is injected i.v. Various doses of Pranlukast (ONO-1078; 40, 20, and 10 mmol/kg), AA-861 (20, 10, and 5 mmol/kg), Indomethacin (40 mmollkg), and the controls are injected s.c. into mice 30 min before they are challenged with 50 p,g of LPS. The maximum soluble doses are 0.6 mmol/mL in 10% DMSO for AA-861 and 1.2 mmol/mL in 10% ethanol for Pranlukast. These solutions are used as the maximum doses for the treatments. The mortality of mice is significantly decreased in AA-861- Pranlukast-treated mice relative to that in the control mice. Pretreatment with CAR (5 mg i.p.) renders the mice more sensitive to the effect of LPS. Although the survival rate of mice treated with each solvent is 20% at 72 h after LPS (50 p,g per mouse) administration, s.c. treatment with AA-861 (20 mmol/kg) or Pranlukast (40 mmol/kg) significantly increases the survival rate after the LPS administration (AA-861, P<0.001; Pranlukast, P<0.01)[3].

IC 50

LTE4: 0.63 nM (Ki); LTD4: 0.99 nM (Ki); LTC4: 5640 nM (Ki)

References

[1] Obata T, et al. In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol. 1992 Nov;60(3):227-37. DOI:10.1254/jjp.60.227
[2] Fang SH, et al. Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells. Acta Pharmacol Sin. 2012 Dec;33(12):1511-7. DOI:10.1038/aps.2012.101
[3] Ogata M, et al. Protective effects of a leukotriene inhibitor and a leukotriene antagonist on endotoxin-induced mortality in carrageenan-pretreated mice. Infect Immun. 1992 Jun;60(6):2432-7. DOI:10.1128/iai.60.6.2432-2437.1992

8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Preparation Products And Raw materials

Raw materials

Preparation Products

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8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Suppliers

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150821-03-7, 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyranRelated Search:

Haloperidol Zafirlukast Pranlukast 4-ETHOXY-N-PHENYLBENZAMIDE 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE 3-Amino-2-hydroxyacetophenone 4-ethoxy-N-(2-methoxyphenyl)benzamide 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE

  • PRANLUKASTHEMIHYDRATE
  • 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
  • N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide hemihydrate
  • Pranlukast hemihydrate >=98% (HPLC), white solid
  • Benzamide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-,hydrate (2:1)
  • N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phe...
  • Pranlukast hydrateQ: What is Pranlukast hydrate Q: What is the CAS Number of Pranlukast hydrate Q: What is the storage condition of Pranlukast hydrate
  • N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide,hydrate
  • N-[4-oxo-2-(1H-1,2,3,4-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide hydrate
  • 150821-03-7
  • 2C27H23N5O4H2O
  • C54H48N10O9