8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran

Product Name: 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
CAS No.: 150821-03-7
Chemical Name: 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran
Synonyms: PRANLUKASTHEMIHYDRATE;Pranlukast hemihydrate >=98% (HPLC), white solid;N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phe...;8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran;N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide,hydrate;N-[4-oxo-2-(1H-1,2,3,4-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide hydrate;N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide hemihydrate;Benzamide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-,hydrate (2:1);Pranlukast hydrateQ: What is Pranlukast hydrate Q: What is the CAS Number of Pranlukast hydrate Q: What is the storage condition of Pranlukast hydrate
CBNumber: CB22130178
Molecular Formula: C27H25N5O5
Formula Weight: 499.53
MOL File: 150821-03-7.mol

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8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Property

storage temp.: -20°C
solubility: DMSO: ≥10mg/mL
form: white solid
color: White to off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26-36/37
WGK Germany: 3
HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: P0080
Product name: Pranlukast hemihydrate
Purity: ≥98% (HPLC), white solid
Packaging: 5mg
Price: $152
Updated: 2025/07/31

Sigma-Aldrich

Product number: P0080
Product name: Pranlukast hemihydrate
Purity: ≥98% (HPLC), white solid
Packaging: 25mg
Price: $597
Updated: 2025/07/31

Matrix Scientific

Product number: 047904
Product name: Pranlukast hemihydrate
Purity: >95%
Packaging: 500mg
Price: $625
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0003910
Product name: PRANLUKAST HYDRATE
Purity: 95.00%
Packaging: 250MG
Price: $870.45
Updated: 2021/12/16

AK Scientific

Product number: 4675AD
Product name: Pranlukast hemihydrate
Packaging: 500mg
Price: $893
Updated: 2021/12/16

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8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Chemical Properties,Usage,Production

Uses

Pranlukast hemihydrate is a highly potent, selective and competitive antagonist of peptide leukotrienes. Pranlukast inhibits [3H]LTE4, [3H]LTD4, and [3H]LTC4 bindings to lung membranes with Kis of 0.63±0.11, 0.99±0.19, and 5640±680 nM, respectively.

Biochem/physiol Actions

Pranlukast is a subtype specific CysLT1 receptor antagonist. Leukotrienes are involved in the inflammation response and are divided into two main classes; leukotriene B4 and cysteinyl-substituted leukotrienes.

in vivo

Carrageenan (CAR, 5 mg per mouse) is injected i.p. 24 h before LPS (50 p,g per mouse) is injected i.v. Various doses of Pranlukast (ONO-1078; 40, 20, and 10 mmol/kg), AA-861 (20, 10, and 5 mmol/kg), Indomethacin (40 mmollkg), and the controls are injected s.c. into mice 30 min before they are challenged with 50 p,g of LPS. The maximum soluble doses are 0.6 mmol/mL in 10% DMSO for AA-861 and 1.2 mmol/mL in 10% ethanol for Pranlukast. These solutions are used as the maximum doses for the treatments. The mortality of mice is significantly decreased in AA-861- Pranlukast-treated mice relative to that in the control mice. Pretreatment with CAR (5 mg i.p.) renders the mice more sensitive to the effect of LPS. Although the survival rate of mice treated with each solvent is 20% at 72 h after LPS (50 p,g per mouse) administration, s.c. treatment with AA-861 (20 mmol/kg) or Pranlukast (40 mmol/kg) significantly increases the survival rate after the LPS administration (AA-861, P<0.001; Pranlukast, P<0.01)^[3].

IC 50

LTE₄: 0.63 nM (Ki); LTD₄: 0.99 nM (Ki); LTC₄: 5640 nM (Ki)

References

[1] Obata T, et al. In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol. 1992 Nov;60(3):227-37. DOI:10.1254/jjp.60.227
[2] Fang SH, et al. Nuclear translocation of cysteinyl leukotriene receptor 1 is involved in oxygen-glucose deprivation-induced damage to endothelial cells. Acta Pharmacol Sin. 2012 Dec;33(12):1511-7. DOI:10.1038/aps.2012.101
[3] Ogata M, et al. Protective effects of a leukotriene inhibitor and a leukotriene antagonist on endotoxin-induced mortality in carrageenan-pretreated mice. Infect Immun. 1992 Jun;60(6):2432-7. DOI:10.1128/iai.60.6.2432-2437.1992

8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Preparation Products And Raw materials

Raw materials

Preparation Products

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8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran Suppliers

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150821-03-7, 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyranRelated Search:

Haloperidol Zafirlukast Pranlukast 4-ETHOXY-N-PHENYLBENZAMIDE 8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran 4-METHOXY-N-(2-METHOXYPHENYL)BENZAMIDE 3-Amino-2-hydroxyacetophenone 4-ethoxy-N-(2-methoxyphenyl)benzamide 3''-ACETYL-2''-HYDROXY-4-(4-PHENYLBUTOXY)BENZANILIDE

PRANLUKASTHEMIHYDRATE

8-[4(4-phenylbutoxy)benzoyl]amino-2-(5-tetrazolyl)-4-oxo-4H-1-benzopyran

N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-benzamide hemihydrate

Pranlukast hemihydrate >=98% (HPLC), white solid

Benzamide,N-[4-oxo-2-(2H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phenylbutoxy)-,hydrate (2:1)

N-[4-Oxo-2-(1H-tetrazol-5-yl)-4H-1-benzopyran-8-yl]-4-(4-phe...

Pranlukast hydrateQ: What is Pranlukast hydrate Q: What is the CAS Number of Pranlukast hydrate Q: What is the storage condition of Pranlukast hydrate

N-[4-oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide,hydrate

N-[4-oxo-2-(1H-1,2,3,4-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide hydrate

150821-03-7

2C27H23N5O4H2O

C54H48N10O9