2-Chloro-4-iodopyridine-3-carboxaldehyde
Uses- Product Name
- 2-Chloro-4-iodopyridine-3-carboxaldehyde
- CAS No.
- 153034-90-3
- Chemical Name
- 2-Chloro-4-iodopyridine-3-carboxaldehyde
- Synonyms
- 2-Chloro-4-iodonicotinaldehyde;CAS:153034-90-3;oro-4-iodo-pyridine-3-carbaL;2-CHLORO-3-FORMYL-4-IODOPYRIDINE;2-Chloro-4-Iodopyridine-3-Formaldehyde;2-CHLORO-4-IODO-PYRIDINE-3-CARBALDEHYDE;2-CHLORO-4-IODOPYRIDINE-3-CARBOXALDEHYDE;2-Chloro-4-iodo-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 2-chloro-4-iodo-;2-Chloro-4-iodo-pyridine-3-carbaldehyde ,97%
- CBNumber
- CB2213208
- Molecular Formula
- C6H3ClINO
- Formula Weight
- 267.45
- MOL File
- 153034-90-3.mol
2-Chloro-4-iodopyridine-3-carboxaldehyde Property
- Melting point:
- 87-92 °C
- Boiling point:
- 326.6±42.0 °C(Predicted)
- Density
- 2.083±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- solid
- pka
- -1.53±0.10(Predicted)
- Appearance
- Light yellow to yellow Solid
- Sensitive
- Air & Light Sensitive
- InChI
- InChI=1S/C6H3ClINO/c7-6-4(3-10)5(8)1-2-9-6/h1-3H
- InChIKey
- OPZCXONVRBYGHX-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=CC(I)=C1C=O
- CAS DataBase Reference
- 153034-90-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-37
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 722596
- Product name
- 2-Chloro-4-iodopyridine-3-carboxaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $195
- Updated
- 2025/07/31
- Product number
- C360260
- Product name
- 2-Chloro-3-formyl-4-iodopyridine
- Packaging
- 250mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- JK241405
- Product name
- 2-Chloro-4-iodo-pyridine-3-carbaldehyde
- Purity
- 97%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- N414
- Product name
- 2-Chloro-4-iodopyridine-3-carboxaldehyde
- Packaging
- 5g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- CS-D0962
- Product name
- 2-Chloro-4-iodopyridine-3-carbaldehyde
- Purity
- 98.72%
- Packaging
- 10g
- Price
- $109
- Updated
- 2021/12/16
2-Chloro-4-iodopyridine-3-carboxaldehyde Chemical Properties,Usage,Production
Uses
2-Chloro-4-iodopyridine-3-carboxaldehyde is an organic heterocyclic compound that can be used as a pharmaceutical intermediate.
Chemical Properties
Yellow-green solid
Synthesis
78607-36-0
109-94-4
153034-90-3
Example 1: Synthesis of N-(2-(2,6-dichlorophenyl)-2H-pyrazolo[4,3-c]pyridin-4-yl)cyclopropanecarboxamide Step 1: Preparation of 2-chloro-4-iodonicotinaldehyde A solution of 2-chloro-3-iodopyridine (5.0 g, 21 mmol) in anhydrous THF (30 mL) was slowly added dropwise to a solution of lithium diisopropylammonium (15 mL, 30 mmol) in anhydrous THF (50 mL) that was pre-cooled to -78 °C. The reaction mixture was stirred continuously at -78 °C for 3 hours. Subsequently, ethyl formate (4.0 g, 54 mmol) was added to the reaction system and stirring was continued at the same temperature for 1.5 hours. Upon completion of the reaction, the reaction was quenched by the addition of water (10 mL), after which the mixture was slowly warmed to room temperature. THF was removed by distillation under reduced pressure after addition of 2 M HCl (50 mL).The aqueous phase was extracted with ethyl acetate (2 x 50 mL). The organic phases were combined, washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: ether/petroleum ether=1:4) to afford the target compound 2-chloro-4-iodonicotinaldehyde as a yellow solid (3.0 g, 54% yield). NMR (500MHz, CDCl3): δ10.22 (s, 1H), 8.09 (d, J=5.0Hz, 1H), 7.95 (d, J=5.0Hz, 1H).
References
[1] Synthetic Communications, 1996, vol. 26, # 23, p. 4421 - 4436
[2] Journal of Organic Chemistry, 1993, vol. 58, # 27, p. 7832 - 7838
[3] Journal of Heterocyclic Chemistry, 2001, vol. 38, # 5, p. 1039 - 1044
[4] Patent: WO2012/66061, 2012, A1. Location in patent: Page/Page column 76-77
2-Chloro-4-iodopyridine-3-carboxaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-4-iodopyridine-3-carboxaldehyde Suppliers
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View Lastest Price from 2-Chloro-4-iodopyridine-3-carboxaldehyde manufacturers
- Product
- 2-Chloro-4-iodopyridine-3-carboxaldehyde 153034-90-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-29
- Product
- 2-Chloro-4-iodopyridine-3-carboxaldehyde 153034-90-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.1%
- Supply Ability
- 100 tons
- Release date
- 2022-02-08
- Product
- 2-Chloro-4-iodopyridine-3-carboxaldehyde 153034-90-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01