2-Bromo-3-iodopyridine
- Product Name
- 2-Bromo-3-iodopyridine
- CAS No.
- 265981-13-3
- Chemical Name
- 2-Bromo-3-iodopyridine
- Synonyms
- Pyridine, 2-bromo-3-iodo-;2-Bromo-3-iodopyridine, CAS 265981-13-3;2-Bromo-3-iodopyridine ISO 9001：2015 REACH
- CBNumber
- CB51471110
- Molecular Formula
- C5H3BrIN
- Formula Weight
- 283.89
- MOL File
- 265981-13-3.mol
2-Bromo-3-iodopyridine Property
- Melting point:
- 95-100°C
- Boiling point:
- 284℃
- Density
- 2.347
- Flash point:
- 126℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- powder to crystal
- pka
- -1.23±0.10(Predicted)
- color
- Light yellow to Brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H400Very toxic to aquatic life
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 704857
- Product name
- 2-Bromo-3-iodopyridine
- Packaging
- 1g
- Price
- $105
- Updated
- 2023/06/20
- Product number
- B5201
- Product name
- 2-Bromo-3-iodopyridine
- Purity
- >95.0%(GC)
- Packaging
- 1g
- Price
- $68
- Updated
- 2025/07/31
- Product number
- B5201
- Product name
- 2-Bromo-3-iodopyridine
- Purity
- >95.0%(GC)
- Packaging
- 5g
- Price
- $236
- Updated
- 2025/07/31
- Product number
- Z0455
- Product name
- 2-Bromo-3-iodopyridine
- Packaging
- 5g
- Price
- $277
- Updated
- 2021/12/16
- Product number
- FB153837
- Product name
- 2-Bromo-3-iodopyridine
- Packaging
- 2g
- Price
- $187
- Updated
- 2021/12/16
2-Bromo-3-iodopyridine Chemical Properties,Usage,Production
Synthesis
109-04-6
265981-13-3
a) Under argon protection, n-BuLi (12.78 mL, 2.5 M hexane solution, 31.96 mmol) was slowly added dropwise to a tetrahydrofuran (THF, 100 mL) solution of iPr2NH (4.44 mL, 31.96 mmol), and the reaction system was maintained at -45 °C. After stirring for 0.5 h, the reaction mixture was further cooled to -95 °C (toluene/liquid nitrogen bath), followed by the addition of 2-bromopyridine (3.02 mL, 31.65 mmol). The reaction mixture was stirred at -95 °C to -90 °C for 3 to 4 hours, then iodine (I2, 8.03 g, 31.65 mmol) was added in batches. The reaction mixture was slowly warmed to room temperature and stirred overnight. The reaction was quenched with 10% aqueous acetic acid (HOAc), the pH was adjusted to 8-9 and distilled water (50 mL) was added. The organic phase was extracted with ether and the combined organic phases were dried with anhydrous K2CO3. The solvent was removed by concentration under reduced pressure to give the crude 2-bromo-3-iodopyridine as a brown powder. The crude product was dried with KOH pellets under vacuum for 3 hours. The purity of 2-bromo-3-iodopyridine (7.66 g, 85% yield) was confirmed by 1H NMR analysis and used directly in the next reaction.1H NMR (499.93 MHz, CDCl3, 25 °C): δ = 8.05 (dd, J = 0.6, 5.2 Hz, 1H), 7.91 (dd, J = 0.6, 1.5 Hz, 1H), 7.62 ( dd, J = 1.5, 5.2 Hz, 1H). The data obtained are in agreement with those reported in the literature [17].
References
[1] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 2682 - 2688
[2] Tetrahedron Letters, 2008, vol. 49, # 17, p. 2839 - 2843
[3] Chemical Communications, 2001, # 23, p. 2450 - 2451
[4] Synthesis, 2004, # 16, p. 2614 - 2616
[5] Angewandte Chemie - International Edition, 2008, vol. 47, # 9, p. 1662 - 1667
2-Bromo-3-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Bromo-3-iodopyridine manufacturers
- Product
- 2-Bromo-3-iodopyridine 265981-13-3
- Price
- US $200.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%, 99.5% Sublimated
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-30
- Product
- 2-Bromo-3-iodopyridine 265981-13-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 2-Bromo-3-iodopyridine 265981-13-3
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%-99%
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-07