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2-Bromo-3-iodopyridine

Product Name
2-Bromo-3-iodopyridine
CAS No.
265981-13-3
Chemical Name
2-Bromo-3-iodopyridine
Synonyms
Pyridine, 2-bromo-3-iodo-;2-Bromo-3-iodopyridine, CAS 265981-13-3;2-Bromo-3-iodopyridine ISO 9001：2015 REACH
CBNumber
CB51471110
Molecular Formula
C5H3BrIN
Formula Weight
283.89
MOL File
265981-13-3.mol
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2-Bromo-3-iodopyridine Property

Melting point:
95-100°C
Boiling point:
284℃
Density 
2.347
Flash point:
126℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
form 
powder to crystal
pka
-1.23±0.10(Predicted)
color 
Light yellow to Brown
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Safety

Hazard Codes 
Xn,N
Risk Statements 
22-41-50
Safety Statements 
26-39-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
704857
Product name
2-Bromo-3-iodopyridine
Packaging
1g
Price
$105
Updated
2023/06/20
TCI Chemical
Product number
B5201
Product name
2-Bromo-3-iodopyridine
Purity
>95.0%(GC)
Packaging
1g
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
B5201
Product name
2-Bromo-3-iodopyridine
Purity
>95.0%(GC)
Packaging
5g
Price
$236
Updated
2025/07/31
AK Scientific
Product number
Z0455
Product name
2-Bromo-3-iodopyridine
Packaging
5g
Price
$277
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB153837
Product name
2-Bromo-3-iodopyridine
Packaging
2g
Price
$187
Updated
2021/12/16
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2-Bromo-3-iodopyridine Chemical Properties,Usage,Production

Synthesis

109-04-6

265981-13-3

a) Under argon protection, n-BuLi (12.78 mL, 2.5 M hexane solution, 31.96 mmol) was slowly added dropwise to a tetrahydrofuran (THF, 100 mL) solution of iPr2NH (4.44 mL, 31.96 mmol), and the reaction system was maintained at -45 °C. After stirring for 0.5 h, the reaction mixture was further cooled to -95 °C (toluene/liquid nitrogen bath), followed by the addition of 2-bromopyridine (3.02 mL, 31.65 mmol). The reaction mixture was stirred at -95 °C to -90 °C for 3 to 4 hours, then iodine (I2, 8.03 g, 31.65 mmol) was added in batches. The reaction mixture was slowly warmed to room temperature and stirred overnight. The reaction was quenched with 10% aqueous acetic acid (HOAc), the pH was adjusted to 8-9 and distilled water (50 mL) was added. The organic phase was extracted with ether and the combined organic phases were dried with anhydrous K2CO3. The solvent was removed by concentration under reduced pressure to give the crude 2-bromo-3-iodopyridine as a brown powder. The crude product was dried with KOH pellets under vacuum for 3 hours. The purity of 2-bromo-3-iodopyridine (7.66 g, 85% yield) was confirmed by 1H NMR analysis and used directly in the next reaction.1H NMR (499.93 MHz, CDCl3, 25 °C): δ = 8.05 (dd, J = 0.6, 5.2 Hz, 1H), 7.91 (dd, J = 0.6, 1.5 Hz, 1H), 7.62 ( dd, J = 1.5, 5.2 Hz, 1H). The data obtained are in agreement with those reported in the literature [17].

References

[1] Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 2682 - 2688
[2] Tetrahedron Letters, 2008, vol. 49, # 17, p. 2839 - 2843
[3] Chemical Communications, 2001, # 23, p. 2450 - 2451
[4] Synthesis, 2004, # 16, p. 2614 - 2616
[5] Angewandte Chemie - International Edition, 2008, vol. 47, # 9, p. 1662 - 1667

2-Bromo-3-iodopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-3-iodopyridine Suppliers

Americas 1 China 101 Europe 1 Germany 1 India 8 Japan 1 United Kingdom 2 United States 13 Global 128
TCI AMERICA
Tel
800-4238616
Fax
+1-888-520-1075 / +1-503-283-1987
Email
sales@tciamerica.com
Country
Americas
ProdList
23653
Advantage
75
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View Lastest Price from 2-Bromo-3-iodopyridine manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Bromo-3-iodopyridine 265981-13-3
Price
US $200.00-1.00/KG
Min. Order
1KG
Purity
99%, 99.5% Sublimated
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-30
Dideu Industries Group Limited
Product
2-Bromo-3-iodopyridine 265981-13-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-01
Career Henan Chemical Co
Product
2-Bromo-3-iodopyridine 265981-13-3
Price
US $5.50/KG
Min. Order
1KG
Purity
98%-99%
Supply Ability
1kg-100kg
Release date
2020-01-07

265981-13-3, 2-Bromo-3-iodopyridineRelated Search:

2-Chloro-3-iodopyridine 2-BROMO-4,6-DIMETHYLPYRIDINE 2-CHLORO-4-IODO-3-METHYLPYRIDINE 2-Chloro-4,6-dimethylpyridine 2-Chloro-3-pyridylboronic acid 2-Bromopyridine-5-carbaldehyde 2-Bromo-4-iodopyridine 2-BROMO-3-FORMYLPYRIDINE 2-Chloro-4-iodopyridine-3-carboxaldehyde 2-BROMO-3,5-DIIODOPYRIDINE 2-BROMO-3-IODO-ISONICOTINIC ACID 2-Bromo-3-iodopyridine 2-BROMO-3-IODO-5-METHYLPYRIDINE 6-BROMO-5-IODOPYRIDIN-3-AMINE 2-BROMO-3-IODO-4,6-DIMETHYLPYRIDINE 6-BROMO-5-IODOPYRIDIN-3-OL 2-BROMO-3-IODO-5-NITROPYRIDINE 2-Bromo-3-iodo-4-methyl pyridine

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  • 2-Bromo-3-iodopyridine ISO 9001：2015 REACH
  • 2-Bromo-3-iodopyridine, CAS 265981-13-3
  • 265981-13-3
  • Propidium heterocyclic series