ChemicalBook > CAS DataBase List > Cyclopropylacetylene

Cyclopropylacetylene

Product Name: Cyclopropylacetylene
CAS No.: 6746-94-7
Chemical Name: Cyclopropylacetylene
Synonyms: ETHYNYLCYCLOPROPANE;CYCLOPROPYLACETYLENE;CPAC;Cylopropylethylnen;Cylopropyl acetylene;Cyclopropyl acetylen;Cyclopropylacethylene;Cyclopropane,ethynyl-;CYCLOPROPYL ACETHLENE;ethylnyl-cyclopropane
CBNumber: CB2214654
Molecular Formula: C5H6
Formula Weight: 66.1
MOL File: 6746-94-7.mol

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Cyclopropylacetylene Property

Melting point:: 294 °C (decomp)
Boiling point:: 79-80 °C
Density: 0.7801
refractive index: n20/D 1.4480
Flash point:: -5 °F
storage temp.: 2-8°C
solubility: Chloroform, Ethyl Acetate
form: Liquid
Specific Gravity: 0.797
color: Clear colorless to light yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C5H6/c1-2-5-3-4-5/h1,5H,3-4H2
InChIKey: NPTDXPDGUHAFKC-UHFFFAOYSA-N
SMILES: C1(C#C)CC1
CAS DataBase Reference: 6746-94-7(CAS DataBase Reference)
NIST Chemistry Reference: Cyclopropylacetylene(6746-94-7)

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Safety

Hazard Codes: F,Xn,Xi
Risk Statements: 11-36/37/38-48/20-63-65-67-52/53-41-38-4-37/38-22
Safety Statements: 26-36/37-62-37/39-16-61-33-9-36/37/39-39
RIDADR: UN 1294 3/PG 2
WGK Germany: 2
HazardClass: IRRITANT, FLAMMABLE
HazardClass: 3
PackingGroup: II
HS Code: 29021990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H315Causes skin irritation

H318Causes serious eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 663018
Product name: Cyclopropylacetylene
Purity: Neat, 97%
Packaging: 5g
Price: $58.4
Updated: 2025/07/31

Sigma-Aldrich

Product number: 663018
Product name: Cyclopropylacetylene
Purity: Neat, 97%
Packaging: 25g
Price: $97.9
Updated: 2025/07/31

TCI Chemical

Product number: C1984
Product name: Cyclopropylacetylene
Purity: >98.0%(GC)
Packaging: 5g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: C1984
Product name: Cyclopropylacetylene
Purity: >98.0%(GC)
Packaging: 25g
Price: $94
Updated: 2025/07/31

GFS CHEMICALS

Product number: 89551
Product name: CYCLOPROPYLACETYLENE,98%
Packaging: 10g
Price: $68.33
Updated: 2021/12/16

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Cyclopropylacetylene Chemical Properties,Usage,Production

Preparation

Cyclopropylacetylene was prepared in a two-step procedure by dichlorination of cyclopropyl methyl ketone with phosphorus pentachloride (PCl5) followed by double dehydrohalogenation with a strong base. This sequence presented significant scale-up problems with low overall yields (20-25%).
Similarly, cyclopropylacetylene has been prepared by base-induced dehydrohalogenation of bromovinylcyclopropane . Cyclopropylacetylene has also been prepared from the 1-trimethylsilyl derivative of cyclopropylacetylene, which was prepared by treatment of 5-chloro-1-trimethylsilyl-1-pentyne with lithium diisopropylamide at ?78°C followed by warming to room temperature.

Chemical Properties

clear colorless to light yellow liquid

Uses

Cyclopropylacetylene is used as an organic chemical synthesis intermediate.

Synthesis

40459-85-6

6746-94-7

The general procedure for synthesizing cyclopropylacetylene from (1,1-dichloroethyl)cyclopropane was as follows: 1) 80 g of sodium hydroxide was mixed with 300 mL of ethoxyethanol and stirred at -60 °C, followed by the slow addition of 100 g of chlorocyclopropylacetylene at the same temperature. After the reaction was completed (the reaction process was monitored by gas chromatography analysis), atmospheric pressure distillation was performed to collect the 55 °C-65 °C fraction to obtain crude cyclopropylacetylene; 2) The crude cyclopropylacetylene was purified by distillation with continuous stirring. Finally, 59 g of cyclopropylacetylene with a purity greater than 98% was obtained, with a yield of 89%.

References

[1] Patent: CN105985223, 2016, A. Location in patent: Paragraph 0049; 0050; 0051; 0052
[2] Journal of Organic Chemistry, 1976, vol. 41, # 7, p. 1237 - 1240
[3] Synthesis, 1972, p. 703
[4] Journal of the American Chemical Society, 1972, vol. 94, p. 1158 - 1163
[5] Synlett, 1999, # 12, p. 1948 - 1950

Cyclopropylacetylene Preparation Products And Raw materials

Raw materials

Preparation Products

Efavirenz

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View Lastest Price from Cyclopropylacetylene manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Cyclopropyl acetylene 6746-94-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-19

R&D Scientific Inc.

Product: Ethynylcyclopropane 6746-94-7
Price: US $786.00/Kg
Min. Order: 0.100Kg
Purity: 99 %
Supply Ability: 5000 Kg
Release date: 2025-04-08

Henan Aochuang Chemical Co.,Ltd.

Product: Cyclopropyl acetylene 6746-94-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-10-10

6746-94-7, CyclopropylacetyleneRelated Search:

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6746-94-7

6746-97-7

C5H6

C3H5CCH

C3H5C8801CH

Organic Building Blocks

Terminal

Building Blocks

Alkynes

Acetylenes

Cyclopropanes

Functionalized Acetylenes

Simple 3-Membered Ring Compounds

Alkynes

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Organic Building Blocks

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Pharmaceutical Intermediates

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6746-94-7