4-Bromo-2-fluorobenzyl bromide

Product Name: 4-Bromo-2-fluorobenzyl bromide
CAS No.: 76283-09-5
Chemical Name: 4-Bromo-2-fluorobenzyl bromide
Synonyms: à,4-dibromo-2-fluorotoluene;4,α-dibromo-2-fluorotoluene;4-Bromo-2-fluoroben bromide;4-BroMo-2-fluorobenl broMide;2-fluor-4-bromobenzyl bromide;4-BROMO-2-FLUOROBENZYL BROMIDE;4-Bromo-1-Fluorobenzyl Bromide;2-FLUORO-4-BROMOBENZYL BROMIDE;4-Bromo-2-fluorobenzylbromide97%;4-Bromo-2-fluorobenzyl bromide 97%
CBNumber: CB2217453
Molecular Formula: C7H5Br2F
Formula Weight: 267.92
MOL File: 76283-09-5.mol

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4-Bromo-2-fluorobenzyl bromide Property

Melting point:: 33-36 °C (lit.)
Boiling point:: 126 °C (19 mmHg)
Density: 1.9094 (rough estimate)
refractive index: 1.5770 (estimate)
Flash point:: 126°C/9mm
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: Low Melting Solid
color: White to off-white
Sensitive: Lachrymatory
BRN: 4307676
InChI: InChI=1S/C7H5Br2F/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
InChIKey: XMHNLZXYPAULDF-UHFFFAOYSA-N
SMILES: C1(CBr)=CC=C(Br)C=C1F
CAS DataBase Reference: 76283-09-5(CAS DataBase Reference)

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Safety

Hazard Codes: C
Risk Statements: 22-34-52/53-20/21/22
Safety Statements: 26-36/37/39-45-61
RIDADR: UN 2923 8/PG 3
WGK Germany: 2
Hazard Note: Corrosive/Lachrymatory
HazardClass: 8
PackingGroup: III
HS Code: 29039990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 477559
Product name: 4-Bromo-2-fluorobenzyl bromide
Purity: 98%
Packaging: 5g
Price: $36.7
Updated: 2023/06/20

TCI Chemical

Product number: B1934
Product name: 4-Bromo-2-fluorobenzyl Bromide
Purity: >98.0%(GC)
Packaging: 5g
Price: $33
Updated: 2025/07/31

TCI Chemical

Product number: B1934
Product name: 4-Bromo-2-fluorobenzyl Bromide
Purity: >98.0%(GC)
Packaging: 25g
Price: $96
Updated: 2025/07/31

TRC

Product number: B692153
Product name: 4-Bromo-2-fluorobenzyl bromide
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

TRC

Product number: B692153
Product name: 4-Bromo-2-fluorobenzyl bromide
Packaging: 5g
Price: $75
Updated: 2021/12/16

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4-Bromo-2-fluorobenzyl bromide Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Uses

4-Bromo-2-fluorobenzyl bromide may be used in the synthesis of 1-(2-fluoro-4-(1-methyl-1H-pyrazol-4-yl)benzyl)indoline-2,3-dione.

General Description

4-Bromo-2-fluorobenzyl bromide is a substituted benzyl bromide. Its density is 1.9094g/ml at 25°C.

Synthesis

51436-99-8

76283-09-5

General procedure for the synthesis of 2-fluoro-4-bromobenzyl bromide from 2-fluoro-4-bromotoluene: N-bromosuccinimide (NBS, 1.07 g, 6.05 mmol) and azobisisobutyronitrile (AIBN, 83 mg, 0.50 mmol) were dissolved in carbon tetrachloride (CCl4, 10 mL), followed by addition of 2-fluoro-4-bromotoluene (1 g, 5.04 mmol). The reaction mixture was heated to reflux at 100 °C for 13 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the resulting solid was collected by filtration. The filtrate was extracted several times with carbon tetrachloride and water. The organic layers were combined and dried with anhydrous sodium sulfate to remove residual water. Subsequently, the organic layer was concentrated under reduced pressure to afford 4-bromo-1-(bromomethyl)-2-fluorobenzene (1.2 g, 4.47 mmol) in 89% yield. The product was characterized by 1H-NMR (300 MHz, CDCl3): δ 7.51-7.41 (m, 1H), 7.09 (d, J=9.0 Hz, 1H), 6.99 (d, J=8.2 Hz, 1H), 4.34 (s, 2H).

References

[1] Patent: US2015/259350, 2015, A1. Location in patent: Paragraph 0169; 1070
[2] Patent: KR101745741, 2017, B1. Location in patent: Paragraph 0268
[3] Patent: WO2014/76104, 2014, A1. Location in patent: Page/Page column 66
[4] Journal of Medicinal Chemistry, 1995, vol. 38, # 15, p. 2938 - 2945
[5] European Journal of Pharmaceutical Sciences, 2006, vol. 27, # 2-3, p. 188 - 193

4-Bromo-2-fluorobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Bromo-2-fluorobenzyl bromide Suppliers

Americas 1 Belgium 1 China 233 Europe 4 France 1 Germany 2 India 7 Israel 2 Italy 1 Japan 4 Jordan 1 Slovakia 1 Switzerland 2 United Kingdom 19 United States 44 Global 323

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View Lastest Price from 4-Bromo-2-fluorobenzyl bromide manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Bromo-2-fluorobenzyl bromide 76283-09-5
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

Henan Fengda Chemical Co., Ltd

Product: 4-Bromo-2-fluorobenzyl bromide 76283-09-5
Price: US $100.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-24

Career Henan Chemical Co

Product: 4-Bromo-2-fluorobenzyl bromide 76283-09-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 200KG
Release date: 2019-08-30

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2-FLUORO-4-BROMOBENZYL BROMIDE

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4-Bromo-2-fluorobenzylbromide97%

2-fluor-4-bromobenzyl bromide

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1-Bromo-4-bromomethyl-3-fluorobenzene

4-BroMo-2-fluorobenzyl broMide, 99% 5GR

4-Bromo-2-fluoroben bromide

4-Bromo-2-fluorobenzyl bromide,99%

4-BroMo-2-fluorobenl broMide

4-Bromo-1-(bromomethyl)-2-fluorobenzene, alpha,4-Dibromo-2-fluorotoluene

2-Fluoride-4-Bromine Bromine Benzyl

4-Bromo-2-fluorobenzyl Bromide &gt

4-Bromo-2-fluorobenzyl bromide ISO 9001：2015 REACH

76283-09-5

76283-09-6

BrC6H3FCH2Br

BENZYL HALIDE

Aryl

C7

Building Blocks

Halogenated Hydrocarbons

Organic Building Blocks

Fluorine series

Aromatic Halides (substituted)

Fluoro-contained benzyl bromide series

alkyl bromide| alkyl Fluorine

bc0001