(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
- Product Name
- (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
- CAS No.
- 494769-44-7
- Chemical Name
- (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
- Synonyms
- (2-N-BOC-AMINO-THIAZOL-4-YL)-METHANOL;N-Boc-2-amino-(4-hydroxymethyl)thiazole;tert-butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate;tert-butyl 4-(hydroxymethyl)-1,3-thiazol-2-ylcarbamate;(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER;(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%;Carbamic acid, N-[4-(hydroxymethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester
- CBNumber
- CB2221212
- Molecular Formula
- C9H14N2O3S
- Formula Weight
- 230.28
- MOL File
- 494769-44-7.mol
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Property
- Density
- 1.316±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 5.09±0.70(Predicted)
- Appearance
- Off-white to light brown Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H972473
- Product name
- (4-Hydroxymethylthiazol-2-yl)carbamicacidtert-butylester
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- H972473
- Product name
- (4-Hydroxymethylthiazol-2-yl)carbamicacidtert-butylester
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB142903
- Product name
- tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate
- Packaging
- 10g
- Price
- $670
- Updated
- 2021/12/16
- Product number
- COR0000267
- Product name
- (4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $727.65
- Updated
- 2021/12/16
- Product number
- FB142903
- Product name
- tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate
- Packaging
- 5G
- Price
- $393.75
- Updated
- 2021/12/16
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
930303-58-5
494769-44-7
Step 2: Synthesis of tert-butyl (4-hydroxymethylthiazol-2-yl)carbamate Ethyl 2-(bis(tert-butoxycarbonyl)amino)thiazole-4-carboxylate (8.0 g, 21.5 mmol) was dissolved in 160 mL of tetrahydrofuran (THF), and cooled to -15 °C. Under stirring, lithium aluminum hydride (1 M in THF, 23.5 mL, 23.6 mmol) was added slowly and dropwise, keeping the reaction temperature at -15 °C. The reaction mixture was continued to be stirred at -15 °C for 1 hour. Upon completion of the reaction, the reaction was quenched by careful addition of water and subsequently washed with saturated aqueous D-tartaric acid potassium solution. The mixture was extracted three times with ethyl acetate and the organic layers were combined. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel with ethyl acetate/heptane as eluent (5:95→50:50 gradient). The target product (4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester was obtained as a light yellow solid (3.2 g, 77% yield), mass spectrum (MS): m/e = 231.2 ([M+H]+).
References
[1] Patent: US2007/78155, 2007, A1. Location in patent: Page/Page column 32
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Suppliers
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- Country
- United Kingdom
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- Advantage
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View Lastest Price from (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester manufacturers
- Product
- (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester 494769-44-7
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 653
- Release date
- 2019-09-01