(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester

Product Name: (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
CAS No.: 494769-44-7
Chemical Name: (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
Synonyms: (2-N-BOC-AMINO-THIAZOL-4-YL)-METHANOL;N-Boc-2-amino-(4-hydroxymethyl)thiazole;tert-butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate;tert-butyl 4-(hydroxymethyl)-1,3-thiazol-2-ylcarbamate;(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER;(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%;Carbamic acid, N-[4-(hydroxymethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester
CBNumber: CB2221212
Molecular Formula: C9H14N2O3S
Formula Weight: 230.28
MOL File: 494769-44-7.mol

More

Less

(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Property

Density: 1.316±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 5.09±0.70(Predicted)
Appearance: Off-white to light brown Solid

More

Less

Safety

HazardClass: IRRITANT

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TRC

Product number: H972473
Product name: (4-Hydroxymethylthiazol-2-yl)carbamicacidtert-butylester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H972473
Product name: (4-Hydroxymethylthiazol-2-yl)carbamicacidtert-butylester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142903
Product name: tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate
Packaging: 10g
Price: $670
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: COR0000267
Product name: (4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER
Purity: 95.00%
Packaging: 1G
Price: $727.65
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB142903
Product name: tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate
Packaging: 5G
Price: $393.75
Updated: 2021/12/16

More

Less

(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Chemical Properties,Usage,Production

Synthesis

930303-58-5

494769-44-7

Step 2: Synthesis of tert-butyl (4-hydroxymethylthiazol-2-yl)carbamate Ethyl 2-(bis(tert-butoxycarbonyl)amino)thiazole-4-carboxylate (8.0 g, 21.5 mmol) was dissolved in 160 mL of tetrahydrofuran (THF), and cooled to -15 °C. Under stirring, lithium aluminum hydride (1 M in THF, 23.5 mL, 23.6 mmol) was added slowly and dropwise, keeping the reaction temperature at -15 °C. The reaction mixture was continued to be stirred at -15 °C for 1 hour. Upon completion of the reaction, the reaction was quenched by careful addition of water and subsequently washed with saturated aqueous D-tartaric acid potassium solution. The mixture was extracted three times with ethyl acetate and the organic layers were combined. The organic layer was dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by fast column chromatography on silica gel with ethyl acetate/heptane as eluent (5:95→50:50 gradient). The target product (4-hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester was obtained as a light yellow solid (3.2 g, 77% yield), mass spectrum (MS): m/e = 231.2 ([M+H]+).

References

[1] Patent: US2007/78155, 2007, A1. Location in patent: Page/Page column 32

(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

(4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester Suppliers

China 67 Germany 1 India 2 Japan 1 United Kingdom 2 United States 12 Global 85

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 52923
Advantage: 58

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

Alfa Chemistry

Tel: --
Fax: --
Email: info@Alfa-Chemistry.com
Country: United States
ProdList: 6814
Advantage: 0

Sphinx Scientific Laboratory, LLC

Tel: --
Fax: --
Email: sales@sphinxscientificlab.com
Country: United States
ProdList: 3343
Advantage: 50

SynChem，Inc

Tel: --
Fax: --
Email: sales@synchem.com
Country: United States
ProdList: 4697
Advantage: 58

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Chemcia Scientific, LLC

Tel: --
Fax: --
Email: sales@chemcia.com
Country: United States
ProdList: 1412
Advantage: 0

AstaTech, Inc

Tel: --
Fax: --
Email: sales@astatechinc.com
Country: United States
ProdList: 6371
Advantage: 58

Synchem Inc.

Tel: --
Fax: --
Email: catalog@synchem.com
Country: United States
ProdList: 1154
Advantage: 46

More

Less

View Lastest Price from (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester manufacturers

Career Henan Chemical Co

Product: (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester 494769-44-7
Price: US $7.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: JD 653
Release date: 2019-09-01

494769-44-7, (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl esterRelated Search:

tert-Butyl carbamate Dibutyl phthalate Methyl anthranilate POLYURETHANE Methyl acrylate BUTYL OLEATE tert-Butyl peroxybenzoate tert-Butyl 4-aminobenzoate 2-(2-Aminothiazol-4-yl)glyoxylic acid Urethane Tris(trimethylsilyl)phosphate tert-Butyl glycinate Buprofezin Diisobutyl phthalate Cyhalofop-butyl 4-Aminobenzoic acid tert-Butyl carbazate t-butyl chloroformate

(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER

(2-N-BOC-AMINO-THIAZOL-4-YL)-METHANOL

N-Boc-2-amino-(4-hydroxymethyl)thiazole

tert-butyl 4-(hydroxymethyl)thiazol-2-ylcarbamate

tert-butyl 4-(hydroxymethyl)-1,3-thiazol-2-ylcarbamate

(4-HYDROXYMETHYLTHIAZOL-2-YL)CARBAMIC ACID TERT-BUTYL ESTER, 95+%

Carbamic acid, N-[4-(hydroxymethyl)-2-thiazolyl]-, 1,1-dimethylethyl ester

494769-44-7

API intermediates