ChemicalBook > CAS DataBase List > N,N'-DIACETYLGLYCINE ANHYDRIDE

N,N'-DIACETYLGLYCINE ANHYDRIDE

Product Name
N,N'-DIACETYLGLYCINE ANHYDRIDE
CAS No.
3027-05-2
Chemical Name
N,N'-DIACETYLGLYCINE ANHYDRIDE
Synonyms
N,N'-Diacetylglycine Anhydride;N,N'-DIACETYLGLYCINE ANHYDRIDE;1,4-DIACETYL-2,5-PIPERAZINEDIONE;1,4-DIACETYL-2,5-DIOXOPIPERAZINE;N,N'-diacetyipiperazin-2,5-dione;1,4-DIACETYL-2,5-DIKETOPIPERAZINE;N,N′-Diacetyl-2,5-dioxopiperazine;1,4-DIACETYL-PIPERAZINE-2,5-DIONE;N,N'-Diacetylglycine Anhydride >2,5-Piperazinedione, 1,4-diacetyl-
CBNumber
CB2223539
Molecular Formula
C8H10N2O4
Formula Weight
198.18
MOL File
3027-05-2.mol
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N,N'-DIACETYLGLYCINE ANHYDRIDE Property

Melting point:
99-100°C
Boiling point:
424.4±38.0 °C(Predicted)
Density 
1.375±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
-1.74±0.20(Predicted)
color 
White to Light yellow to Light orange
BRN 
188115
InChI
InChI=1S/C8H10N2O4/c1-5(11)9-3-8(14)10(6(2)12)4-7(9)13/h3-4H2,1-2H3
InChIKey
CBBKKVPJPRZOCM-UHFFFAOYSA-N
SMILES
N1(C(C)=O)CC(=O)N(C(C)=O)CC1=O
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Safety

Hazard Codes 
Xn
Risk Statements 
36/37/38-43-36/38-22
Safety Statements 
26-36/37/39-36/37
WGK Germany 
3
HS Code 
2933.59.9500
HazardClass 
IRRITANT
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
D1073
Product name
N,N'-Diacetylglycine Anhydride
Purity
>98.0%(GC)
Packaging
10g
Price
$223
Updated
2025/07/31
Oakwood
Product number
080152
Product name
1,4-Diacetylpiperazine-2,5-dione
Purity
98%
Packaging
250mg
Price
$21
Updated
2021/12/16
Matrix Scientific
Product number
043190
Product name
1,4-Diacetyltetrahydro-2,5-pyrazinedione
Purity
>95%
Packaging
1g
Price
$41
Updated
2021/12/16
AK Scientific
Product number
9529AD
Product name
1,4-Diacetyltetrahydro-2,5-pyrazinedione
Packaging
1g
Price
$85
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-1-2D
Product name
1,4-Diacetylpiperazine-2,5-dione
Purity
98.0%
Packaging
5G
Price
$150
Updated
2021/12/16
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N,N'-DIACETYLGLYCINE ANHYDRIDE Chemical Properties,Usage,Production

Description

?N,N'-diacetylglycine anhydride, also known as diacetylated glycylglycine, can be obtained by acylation of glycylglycine with acetic anhydride. N,N'-diacetylglycine anhydride can be used to prepare DL-neopentylglycine derivatives.

Preparation

After the mixed reaction of glycylglycine and acetic anhydride, ethyl acetate and petroleum ether are added in sequence to obtain the intermediate N,N'-diacetylglycine anhydride.

Application

N,N'-diacetylglycine anhydride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical and pharmaceutical synthesis process.

Synthesis

106-57-0

108-24-7

3027-05-2

GENERAL METHOD: 2,5-Piperazinedione (500 mg, 2.5 mmol) was mixed with ethanoic anhydride (20 mL) and reacted at 150°C overnight. Upon completion of the reaction, the excess acetic anhydride was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography to afford 1,4-diacetylpiperazine-2,5-dione.

References

[1] Journal of Organic Chemistry, 2015, vol. 80, # 5, p. 2554 - 2561
[2] Synthesis (Germany), 2014, vol. 46, # 5, p. 621 - 628
[3] European Journal of Medicinal Chemistry, 2014, vol. 83, p. 236 - 244
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1993, # 11, p. 1217 - 1224
[5] Tetrahedron, 2012, vol. 68, # 36, p. 7374 - 7379

N,N'-DIACETYLGLYCINE ANHYDRIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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N,N'-DIACETYLGLYCINE ANHYDRIDE Suppliers

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View Lastest Price from N,N'-DIACETYLGLYCINE ANHYDRIDE manufacturers

PUSHAN INDUSTRIAL (SHAANXI) CO.,LTD
Product
N,N'-Diacetylglycine Anhydride 3027-05-2
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
2 MTs
Release date
2024-08-06
Dideu Industries Group Limited
Product
N,N'-DIACETYLGLYCINE ANHYDRIDE 3027-05-2
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-23
Career Henan Chemical Co
Product
N,N'-DIACETYLGLYCINE ANHYDRIDE 3027-05-2
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2020-01-09

3027-05-2, N,N'-DIACETYLGLYCINE ANHYDRIDERelated Search:

3,6-Pyridazinedione, 1,2-diacetyltetrahydro- 1,4-DIFORMYLPIPERAZINE GLYCINE ANHYDRIDE 1,4-DIACETYL-3,6-DIBENZYLTETRAHYDRO-2,5-PYRAZINEDIONE 1-ACETYL-4-METHYLPIPERAZINE HYDROCHLORIDE 1-Piperazinecarbaldehyde Piperazine, 1,4-diacetyl- (6CI,8CI,9CI) 1-ETHYLPIPERAZIN-2-ONE N,N'-DIACETYLGLYCINE ANHYDRIDE SARCOSINE ANHYDRIDE 1-Methylpiperazin-2-one 2-Piperazinone N,N'-DIACETYLETHYLENEDIAMINE 1-FORMYL-4-METHYLPIPERAZINE 1-Acetylpiperazine

  • 1,4-DIACETYL-PIPERAZINE-2,5-DIONE
  • 1,4-DIACETYLTETRAHYDRO-2,5-PYRAZINEDIONE
  • 1,4-DIACETYL-2,5-DIKETOPIPERAZINE
  • 1,4-DIACETYL-2,5-DIOXOPIPERAZINE
  • 1,4-DIACETYL-2,5-PIPERAZINEDIONE
  • N,N′-Diacetyl-2,5-dioxopiperazine
  • 2,5-Piperazinedione, 1,4-diacetyl-
  • <i>N</i>,<i>N</i>'-Diacetylglycine Anhydride
  • 1,4-Diacetyl-2,5-diketopiperazine 1,4-Diacetyl-2,5-dioxopiperazine 1,4-Diacetyl-2,5-piperazinedione
  • N,N'-Diacetylglycine Anhydride &gt
  • N,N'-DIACETYLGLYCINE ANHYDRIDE ISO 9001：2015 REACH
  • N,N'-Diacetylglycine Anhydride
  • 1,4-Diacetyl-2,5-piperazinedione - [D94521]
  • N,N'-DIACETYLGLYCINE ANHYDRIDE
  • N,N'-diacetyipiperazin-2,5-dione
  • 3027-05-2
  • 3027-5-2
  • 411751