1-(Triphenylmethyl)imidazole

Product Name: 1-(Triphenylmethyl)imidazole
CAS No.: 15469-97-3
Chemical Name: 1-(Triphenylmethyl)imidazole
Synonyms: CDD 3501;N-TRITYLIMIDAZOLE;1-TRITYLIMIDAZOLE;1-TRITYL-1H-IMIDAZOLE;ClotriMazole IMpurity F;Clotrimazole Impurity 6;Clotrimazole EP Impurity F;(TRIPHENYLMETHYL)IMIDAZOLE;1-(TRIPHENYLMETHYL)IMIDAZOLE;N-(Triphenylmethyl)imidazole
CBNumber: CB2228231
Molecular Formula: C22H18N2
Formula Weight: 310.39
MOL File: 15469-97-3.mol

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1-(Triphenylmethyl)imidazole Property

Melting point:: 220-224 °C(lit.)
Boiling point:: 451.3±14.0 °C(Predicted)
Density: 1.05±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form: Solid
pka: 6.34±0.30(Predicted)
color: White to Off-White
Water Solubility: Insoluble in water.
BRN: 238171
InChI: InChI=1S/C22H18N2/c1-4-10-19(11-5-1)22(24-17-16-23-18-24,20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-18H
InChIKey: NPZDCTUDQYGYQD-UHFFFAOYSA-N
SMILES: C1N(C(C2=CC=CC=C2)(C2=CC=CC=C2)C2=CC=CC=C2)C=CN=1
CAS DataBase Reference: 15469-97-3(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
Hazard Note: Irritant
HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR3005
Product name: Clotrimazole Impurity F
Purity: pharmaceutical secondary standard, certified reference material
Packaging: 50MG
Price: $351.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: 524891
Product name: 1-(Triphenylmethyl)imidazole
Purity: 97%
Packaging: 25g
Price: $699
Updated: 2025/07/31

TCI Chemical

Product number: T3316
Product name: 1-Tritylimidazole
Packaging: 5G
Price: $72
Updated: 2025/07/31

TCI Chemical

Product number: T3316
Product name: 1-Tritylimidazole
Packaging: 25G
Price: $288
Updated: 2025/07/31

TRC

Product number: T888120
Product name: 1-Tritylimidazole
Packaging: 25g
Price: $400
Updated: 2021/12/16

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1-(Triphenylmethyl)imidazole Chemical Properties,Usage,Production

Uses

1-(Triphenylmethyl)imidazole may be used in the synthesis of 1,2,5-trisubstituted imidazole derivatives.

Uses

1-Tritylimidazole is a Clotrimazole (C587400) analog as antifungal agent.

General Description

1-(Triphenylmethyl)imidazole is an imidazole derivative.

Synthesis

288-32-4

76-83-5

15469-97-3

The reaction was carried out in a 50 L autoclave using imidazole (880 g, 12.9 mol, 1.0 eq.) and triphenylchloromethane (3605.0 g, 12.9 mol, 1.0 eq.) as raw materials. First, imidazole was dissolved in 12 L of DMF and cooled to below 0 °C. Subsequently, triethylamine (1308 g, 12.9 mol, 1.0 eq.) was added and the reaction was kept for 30 min. A DMF solution of triphenylchloromethane (16 L) was slowly added dropwise to the reaction mixture at 0°C. After the dropwise addition was completed, the reaction system was warmed to 15°C and the reaction was continued with stirring for 16 hours. Upon completion of the reaction, the reaction mixture was poured into water and a large amount of solid was precipitated. The solid was collected by filtration and the filter cake was washed with water, drained and dried to afford N-trityl imidazole (Compound XIV-1) as a white solid 3835.1 g in 95.6% yield.

References

[1] Patent: CN104086553, 2016, B. Location in patent: Paragraph 0065-0068
[2] Patent: US2010/16610, 2010, A1. Location in patent: Page/Page column 28
[3] Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 253 - 256
[4] Tetrahedron, 1999, vol. 55, # 13, p. 4109 - 4122
[5] Patent: US6476216, 2002, B1

1-(Triphenylmethyl)imidazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(Triphenylmethyl)imidazole Suppliers

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View Lastest Price from 1-(Triphenylmethyl)imidazole manufacturers

Career Henan Chemical Co

Product: 1-(Triphenylmethyl)imidazole 15469-97-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-18

15469-97-3, 1-(Triphenylmethyl)imidazoleRelated Search:

Clotrimazole 1-Methylimidazole Imidazole 3-(Trifluoromethyl)benzaldehyde 5-Methyl-1H-benzotriazole Benzotrifluoride N-Fmoc-N'-trityl-D-histidine Fmoc-His(Trt)-OH FMOC-D-HIS(MTT)-OH N-FMOC-3-(triphenylmethyl)-L-histidine 3,5-DIIODO-D-TYROSINE HYDROCHLORIDE N-Fmoc-N'-Trityl-L-histidine pentafluorophenyl ester H-His(Trt)-OH 4-BROMO-1-TRITYL-1H-IMIDAZOLE Boc-His(Trt)-OH 2,5-DIBROMO-1-TRITYLIMIDAZOLE 4-Iodo-1-(triphenylmethyl)imidazole N-α-Fmoc-N-im-trityl-L-histidine N-carboxyanhydride

N-TRITYLIMIDAZOLE

(TRIPHENYLMETHYL)IMIDAZOLE

1-(TRIPHENYLMETHYL)IMIDAZOLE

1-TRITYL-1H-IMIDAZOLE

1-TRITYLIMIDAZOLE

N-(Triphenylmethyl)imidazole

CDD 3501

Clotrimazole Impurity 6(Clotrimazole EP Impurity F)

ClotriMazole IMpurity F

Clotrimazole EP Impurity F

Clotrimazole Impurity 6

1-(Triphenylmethyl)-1H-imidazole (D

1H-Imidazole, 1-(triphenylmethyl)-

Clotrimazole EP Impurity F (Deschloro Clotrimazole)

1-(Triphenylmethyl)-1H-imidazole (Deschloroclotrimazole)

15469-97-3

C22H18N2

C27H21N

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