ChemicalBook > CAS DataBase List > Molsidomine

Molsidomine

Product Name: Molsidomine
CAS No.: 25717-80-0
Chemical Name: Molsidomine
Synonyms: SIN-10;Coruno;morial;CAS 276;CORVATON;corvasal;Corraton;MOTAZOMIN;SydnopharM;molsidolat
CBNumber: CB2234645
Molecular Formula: C9H14N4O4
Formula Weight: 242.23
MOL File: 25717-80-0.mol

Less

Molsidomine Property

Melting point:: 140-141°C
Boiling point:: 385.05°C (rough estimate)
Density: 1.3186 (rough estimate)
refractive index: 1.6300 (estimate)
storage temp.: Inert atmosphere,2-8°C
solubility: Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride.
pka: pK (100°) 3.0 ± 0.1
form: Solid
color: White to Off-White
λmax: 317nm(MeOH)(lit.)
Merck: 14,6234
InChI: InChI=1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3/b10-8-
InChIKey: XLFWDASMENKTKL-NTMALXAHSA-N
SMILES: [N+]1([N-]O/C(=N\C(=O)OCC)/C=1)N1CCOCC1
CAS DataBase Reference: 25717-80-0(CAS DataBase Reference)

Less

Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36
WGK Germany: 3
RTECS: WU7677400
HS Code: 29349990
Toxicity: LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H302Harmful if swallowed

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000821
Product name: Molsidomine
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 5 mg
Price: $159
Updated: 2025/07/31

Sigma-Aldrich

Product number: M2901
Product name: Molsidomine
Packaging: 500mg
Price: $91.1
Updated: 2023/01/07

Sigma-Aldrich

Product number: M2901
Product name: Molsidomine
Packaging: 5g
Price: $522
Updated: 2023/01/07

TCI Chemical

Product number: M2524
Product name: Molsidomine
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $43
Updated: 2025/07/31

TCI Chemical

Product number: M2524
Product name: Molsidomine
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $127
Updated: 2025/07/31

Less

Molsidomine Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Corvasal,Hoechst

Uses

Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.

Definition

ChEBI: 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate is a member of morpholines.

Manufacturing Process

1.6 parts by volume of ethyl chloroformate is stirred dropwise into a suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in 5 parts by volume of pyridine, and the mixture is agitated for a while to allow reaction to take place. Pyridine is removed from the reaction mixture by evaporation, and the residue is dissolved in a small amount of water and extracted with chloroform several times. The extract is dehydrated by adding anhydrous magnesium sulfate and subjected to filtration. Chloroform is removed from the filtrate by distillation, crude crystals being obtained. Recrystallization of the crude crystals from toluene gives 0.6 part by weight of 3-morpholino-N-carboethoxysydnonimine having a melting point of 140°- 141°C. Yield 51%.

brand name

Corvaton (Hoechst-Roussel).

Therapeutic Function

Coronary vasodilator

Molsidomine Preparation Products And Raw materials

Raw materials

N-Aminomorpholine Ethyl chloroformate POTASSIUM CYANIDE

Preparation Products

Less

Molsidomine Suppliers

Americas 1 Canada 1 China 150 Europe 3 France 1 Germany 3 India 5 Japan 1 South Korea 1 Switzerland 3 United Kingdom 6 United States 32 Global 207

JIANGSU BAOSHENG LONGCHENG PHARMACUTICAL CO.,LTD

Tel: 0518-83375738
Fax: 0518-83375737
Email: sales@bslcpharm.com
Country: China
ProdList: 4
Advantage: 60

Shanghai Boyle Chemical Co., Ltd.

Tel: 021-50182298 021-50180596
Fax: +86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2208
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Shanghai Longsheng chemical Co.,Ltd.

Tel: 021-58099652-8005 13585536065
Fax: 021-58099609
Email: bin.wu@shlschem.com
Country: China
ProdList: 9883
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527621225
Email: 1791901229@qq.com
Country: China
ProdList: 6945
Advantage: 52

Shanghai Jin Yi Fine Chemical Co.,LTD

Tel: 021-52801082 13918092929
Fax: 021-52803959
Email: jinyi_service@jyfinechem.com
Country: China
ProdList: 41
Advantage: 57

Wuhan Fortuna Chemical Co., Ltd

Tel: 027-59207852 13308628970
Fax: QQ3130921841
Email: buy@fortunachem.com
Country: China
ProdList: 2744
Advantage: 58

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

Beijing HuaMeiHuLiBiological Chemical

Tel: 010-56205725
Fax: 010-65763397
Email: waley188@sohu.com
Country: China
ProdList: 12335
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4720
Advantage: 55

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7783
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

Shanghai HuanChuan Industry Co.,Ltd.

Tel: 021-61478794
Fax: 021-61478794
Email: sales@hcshhai.com
Country: China
ProdList: 9793
Advantage: 50

Struchem Co., Ltd.

Tel: 0512-63009836 18994340901
Fax: 0512-63006936
Email: helen@struchem.com
Country: China
ProdList: 3981
Advantage: 60

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9287
Advantage: 55

Henan CoreyChem Co., Ltd

Tel: 0371-86658258
Fax: 0371-60996044
Email: info@coreychem.com
Country: China
ProdList: 10453
Advantage: 58

Guangzhou QiYun Biotechnology Co., Ltd.

Tel: 020-61288194 61288195
Fax: 020-61288700
Email: 505721671@qq.com
Country: China
ProdList: 3866
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Shandong Xiya Chemical Co., Ltd.

Tel: 4009903999 13395398332
Fax: 0539-6365991
Email: sales@xiyashiji.com
Country: China
ProdList: 20794
Advantage: 60

Raw material medicin reagent co.,Ltd

Tel
Email: sales@njromanme.com
Country: China
ProdList: 4529
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Shandong Ono Chemical Co., Ltd.

Tel: 0539-6362799 20）
Fax: 0539-6362799（To 20）
Country: China
ProdList: 10007
Advantage: 58

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

Hebei Yanxi Chemical Co., Ltd.

Tel: +8618531123677
Email: faithe@yan-xi.com
Country: China
ProdList: 5853
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: +86-0551-65418671 +8618949823763
Fax: 0551-65418697
Email: sales@tnjchem.com
Country: China
ProdList: 34563
Advantage: 58

Hebei Zhanyao Biotechnology Co. Ltd

Tel: 15369953316 +8615369953316
Email: admin@zhanyaobio.com
Country: China
ProdList: 2123
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: +86-0571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: China
ProdList: 52846
Advantage: 58

Baoji Guokang Healthchem co.,ltd

Tel: +8615604608665 15604608665
Email: dominicguo@gk-bio.com
Country: CHINA
ProdList: 9414
Advantage: 58

Hefei Hirisun Pharmatech Co., Ltd

Tel: +8615056975894
Fax: 86-0551-62678551
Email: shawn@hirisunpharm.com
Country: CHINA
ProdList: 9911
Advantage: 58

Baoji Guokang Healthchem Co., Ltd.

Tel: +86-0917-3909592 +86-13892490616
Fax: 09173909592
Email: gksales1@gk-bio.com
Country: China
ProdList: 9209
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: +86-0571-85134551
Fax: 008657185134895
Email: sales@afinechem.com
Country: China
ProdList: 15109
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-029-89586680 +86-18192503167
Fax: +86-29-88380327
Email: 1026@dideu.com
Country: China
ProdList: 8025
Advantage: 58

SIMAGCHEM CORP

Tel: +86-5922680277 +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17346
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23912
Advantage: 58

Hubei Jusheng Technology Co.,Ltd.

Tel: 18871490254
Fax: 027-59599243
Email: linda@hubeijusheng.com
Country: CHINA
ProdList: 28172
Advantage: 58

Xiamen AmoyChem Co., Ltd

Tel: +86-86-5926051114 +8615060885618
Email: sales@amoychem.com
Country: China
ProdList: 6369
Advantage: 58

Chengdu Peter-like Biotechnology Co., Ltd.

Tel: 18108052721
Email: 2850505130@qq.com
Country: China
ProdList: 5167
Advantage: 58

Shandong chuangyingchemical Co., Ltd.

Tel: 18853181302
Email: sale@chuangyingchem.com
Country: CHINA
ProdList: 5906
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49975
Advantage: 58

career henan chemical co

Tel: +86-0371-86658258 +8613203830695
Fax: 0086-371-86658258
Email: factory@coreychem.com
Country: China
ProdList: 29798
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569262 +86-15003564040
Fax: 029-88380327
Email: 1087@dideu.com
Country: China
ProdList: 3979
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-81139210 +86-18192627656
Fax: +86-29-88380327
Email: 1059@dideu.com
Country: China
ProdList: 3588
Advantage: 58

Shaanxi Dideu Medichem Co. Ltd

Tel: +86-29-87569266 +86-17392581500
Fax: 029-88380327
Email: 1015@dideu.com
Country: China
ProdList: 3987
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 18438616290
Email: lanwu@univ-bio.com
Country: China
ProdList: 24731
Advantage: 58

Less

View Lastest Price from Molsidomine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Molsidomine 25717-80-0
Price: US $300.00-13.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20000KG
Release date: 2025-04-29

Hebei Chuanghai Biotechnology Co., Ltd

Product: Molsidomine 25717-80-0
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-28

Hebei Yanxi Chemical Co., Ltd.

Product: Molsidomine 25717-80-0
Price: US $10.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 20 tons
Release date: 2023-09-14

25717-80-0, MolsidomineRelated Search:

1-(2,6-Dimethylphenoxy)-2-propanamine Ethylbenzene Ethyl acrylate Ethyl formate Ethyl acetate Ethanol CHLOROETHANE Ethylparaben Tris(trimethylsilyl)phosphate Ethyl cellulose 3-MORPHOLINOSYDNONIMINE 4-AMINO-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE/ MOLSIDOMINE Diethyl ether Molsidomine impurity B Molsidomine impurity D Molsidomine MOLSIDOMINE IMP. B (PHARMEUROPA): 4-NITROSOMORPHOLINE MOLSIDOMINE IMP. A (PHARMEUROPA) AS HYDROCHLORIDE:3-(MORPHOLIN-4-YL)SYDNONIMINE HYDROCHLORIDE (LINSIDOMINE HYDROCHLORIDE)

ethyl (3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)aminoformate

CORVATON

N-Carboxy-3-morpholino-syndone imine ethyl ester

corvasal

SIN-10

n-carboxy-3-morpholinosynonimine ethyl ester

N-(ETHOXYCARBONYL)-3-(4-MORPHOLINO)SYDNONE IMINE

N-[ETHOXYCARBONYL]-3-[4-MORPHOLINYL]SYDNONE IMINE

MOTAZOMIN

MORSIDOMINE

MORSYDOMINE

MOLSIDOMINE

5-[(Ethoxycarbonyl)aMino]-3-(4-Morpholinyl)-1,2,3-oxadiazoliuM Inner Salt

CAS 276

Corraton

Coruno

N-(Ethoxycarbonyl)-3-Morpholinosydnone iMine

SIN 10 (pharMaceutical)

SydnopharM

Molsidomine, 98%, Guanylate cyclase activator

N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10

1-Ethoxy-N-(3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)methanimidate

5-Ethoxycarbonyl-3-morpholinosydnonimine

N-(Ethoxycarbonyl)-3-(4-morpholino)syndone imine

N-Ethoxycarbonyl-3-morphalinosydnomine

(1E)-1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate

molsidolat

morial

n-(ethoxycarbonyl)-3-(4-morpholinyl)-sydnoneimin

n-carboxy-3-morpholino-sydnoneiminethylester

n-carboxy-3-morpholinosydnonimineethylester

n-ethoxycarbonyl-3-morpholinosydnonimine

Molsidomine&gt

Molsidomine CRS

Molsidomine USP/EP/BP

(Ethoxycarbonyl)(3-morpholino-1,2,3-oxadiazol-3-ium-5-yl)amide

Molsidomine, ≥ 98.0%

Molsidomine, 10 mM in DMSO

Molsidomine 1.0 mg/ml in Methanol

25717-80-0

C9H14N4O4

Nitric Oxide Metabolism

NO Donors

Cell Signaling Enzymes

Biochemicals and Reagents

Application Index

BioChemical

Enzymes, Inhibitors, and Substrates

Nitric Oxide

API