ChemicalBook > CAS DataBase List > Molsidomine

Molsidomine

Product Name
Molsidomine
CAS No.
25717-80-0
Chemical Name
Molsidomine
Synonyms
SIN-10;Coruno;morial;CAS 276;CORVATON;corvasal;Corraton;MOTAZOMIN;SydnopharM;molsidolat
CBNumber
CB2234645
Molecular Formula
C9H14N4O4
Formula Weight
242.23
MOL File
25717-80-0.mol
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Molsidomine Property

Melting point:
140-141°C
Boiling point:
385.05°C (rough estimate)
Density 
1.3186 (rough estimate)
refractive index 
1.6300 (estimate)
storage temp. 
Inert atmosphere,2-8°C
solubility 
Sparingly soluble in water, soluble in anhydrous ethanol and in methylene chloride.
pka
pK (100°) 3.0 ± 0.1
color 
White to Off-White
λmax
317nm(MeOH)(lit.)
Merck 
14,6234
CAS DataBase Reference
25717-80-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
WU7677400
HS Code 
29349990
Toxicity
LD50 in male, female mice, male, female rats (mg/kg): 780, 750, 1380, 1350 s.c.; 860, 800, 830, 760 i.v.; 700, 760, 1250, 1250 i.p.; 830, 840, 1050, 1200 orally (Nakaguchi)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M2901
Product name
Molsidomine
Packaging
500mg
Price
$91.1
Updated
2023/01/07
Sigma-Aldrich
Product number
M2901
Product name
Molsidomine
Packaging
5g
Price
$522
Updated
2023/01/07
TCI Chemical
Product number
M2524
Product name
Molsidomine
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$48
Updated
2024/03/01
TCI Chemical
Product number
M2524
Product name
Molsidomine
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$141
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000821
Product name
Molsidomine
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000821
Price
$150
Updated
2024/03/01
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Molsidomine Chemical Properties,Usage,Production

Chemical Properties

White to Off-White Solid

Originator

Corvasal,Hoechst

Uses

Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitr ic oxide donor.

Uses

Molsidomine is an antianginal agent. Molsidomine is an effective therapeutic agents in the treatment of angina pectoris. Molsidomine is a sydnonimine derivative that acts as a heterocyclic direct nitric oxide donor.

Definition

ChEBI: 1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate is a member of morpholines.

Manufacturing Process

1.6 parts by volume of ethyl chloroformate is stirred dropwise into a suspension of 1.0 part by weight of 3-morpholinosydnonimine hydrochloride in 5 parts by volume of pyridine, and the mixture is agitated for a while to allow reaction to take place. Pyridine is removed from the reaction mixture by evaporation, and the residue is dissolved in a small amount of water and extracted with chloroform several times. The extract is dehydrated by adding anhydrous magnesium sulfate and subjected to filtration. Chloroform is removed from the filtrate by distillation, crude crystals being obtained. Recrystallization of the crude crystals from toluene gives 0.6 part by weight of 3-morpholino-N-carboethoxysydnonimine having a melting point of 140°- 141°C. Yield 51%.

brand name

Corvaton (Hoechst-Roussel).

Therapeutic Function

Coronary vasodilator

Molsidomine Preparation Products And Raw materials

Raw materials

N-Aminomorpholine Ethyl chloroformate POTASSIUM CYANIDE

Preparation Products

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Molsidomine Suppliers

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JIANGSU BAOSHENG LONGCHENG PHARMACUTICAL CO.,LTD
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View Lastest Price from Molsidomine manufacturers

airuikechemical co., ltd.
Product
molsidomine 25717-80-0
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-04-09
Hebei Yanxi Chemical Co., Ltd.
Product
Molsidomine 25717-80-0
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-14
Hebei Guanlang Biotechnology Co., Ltd.
Product
Molsidomine 25717-80-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2022-10-13

25717-80-0, MolsidomineRelated Search:

Ethanol CHLOROETHANE 1-(2,6-Dimethylphenoxy)-2-propanamine Ethylparaben Tris(trimethylsilyl)phosphate Ethyl cellulose Ethylbenzene Ethyl acrylate Ethyl formate Ethyl acetate Diethyl ether 3-MORPHOLINOSYDNONIMINE 4-AMINO-2-CHLORO-6,7-DIMETHOXYQUINAZOLINE/ MOLSIDOMINE Molsidomine impurity B Molsidomine impurity D Molsidomine MOLSIDOMINE IMP. B (PHARMEUROPA): 4-NITROSOMORPHOLINE MOLSIDOMINE IMP. A (PHARMEUROPA) AS HYDROCHLORIDE:3-(MORPHOLIN-4-YL)SYDNONIMINE HYDROCHLORIDE (LINSIDOMINE HYDROCHLORIDE)

  • ethyl (3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)aminoformate
  • CORVATON
  • N-Carboxy-3-morpholino-syndone imine ethyl ester
  • corvasal
  • SIN-10
  • n-carboxy-3-morpholinosynonimine ethyl ester
  • N-(ETHOXYCARBONYL)-3-(4-MORPHOLINO)SYDNONE IMINE
  • N-[ETHOXYCARBONYL]-3-[4-MORPHOLINYL]SYDNONE IMINE
  • MOTAZOMIN
  • MORSIDOMINE
  • MORSYDOMINE
  • MOLSIDOMINE
  • 5-[(Ethoxycarbonyl)aMino]-3-(4-Morpholinyl)-1,2,3-oxadiazoliuM Inner Salt
  • CAS 276
  • Corraton
  • Coruno
  • N-(Ethoxycarbonyl)-3-Morpholinosydnone iMine
  • SIN 10 (pharMaceutical)
  • SydnopharM
  • Molsidomine, 98%, Guanylate cyclase activator
  • N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10
  • 1-Ethoxy-N-(3-morpholin-4-yl-1-oxa-2-aza-3-azoniacyclopenta-2,4-dien-5-yl)methanimidate
  • 5-Ethoxycarbonyl-3-morpholinosydnonimine
  • N-(Ethoxycarbonyl)-3-(4-morpholino)syndone imine
  • N-Ethoxycarbonyl-3-morphalinosydnomine
  • (1E)-1-ethoxy-N-[3-(4-morpholinyl)-5-oxadiazol-3-iumyl]methanimidate
  • molsidolat
  • morial
  • n-(ethoxycarbonyl)-3-(4-morpholinyl)-sydnoneimin
  • n-carboxy-3-morpholino-sydnoneiminethylester
  • n-carboxy-3-morpholinosydnonimineethylester
  • n-ethoxycarbonyl-3-morpholinosydnonimine
  • Molsidomine&gt
  • Molsidomine CRS
  • Molsidomine USP/EP/BP
  • (Ethoxycarbonyl)(3-morpholino-1,2,3-oxadiazol-3-ium-5-yl)amide
  • Molsidomine, ≥ 98.0%
  • 25717-80-0
  • C9H14N4O4
  • Nitric Oxide Metabolism
  • NO Donors
  • Cell Signaling Enzymes
  • Biochemicals and Reagents
  • Application Index
  • BioChemical
  • Enzymes, Inhibitors, and Substrates
  • Nitric Oxide
  • API