PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-

Product Name: PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
CAS No.: 1638-41-1
Chemical Name: PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
Synonyms: p38 MAPK Inhibitor IV;p38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV (B10);2,2'-Sulfonylbis(3,4,6-trichlorophenol);PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-;p38 MAP Kinase Inhibitor IV,p-38 MAP Kinase Inhibitor IV;p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem;Phenol, 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-
CBNumber: CB22446185
Molecular Formula: C12H4Cl6O4S
Formula Weight: 456.94
MOL File: 1638-41-1.mol

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PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Property

Melting point:: 244-245 °C(Solv: ethyl acetate (141-78-6))
Boiling point:: 590.0±50.0 °C(Predicted)
Density: 1.854±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 2.43±0.50(Predicted)
form: powder
color: white to beige

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0543
Product name: p38 MAP Kinase Inhibitor IV
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: 506153
Product name: p38 MAP Kinase Inhibitor IV
Packaging: 10mg
Price: $230
Updated: 2024/03/01

Cayman Chemical

Product number: 22219
Product name: p38 MAPK Inhibitor IV
Purity: ≥98%
Packaging: 5mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 22219
Product name: p38 MAPK Inhibitor IV
Purity: ≥98%
Packaging: 10mg
Price: $115
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0543
Product name: p38 MAP Kinase Inhibitor IV
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $440
Updated: 2022/05/15

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PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Chemical Properties,Usage,Production

Uses

p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor.

Uses

p38 MAP Kinase Inhibitor IV has been used for blocking p38α kinase activation in order to examine if HOXB7 is involved in the regulation of migration and proliferation process via AKT/MAPK signaling.

General Description

A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC₅₀ = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 μM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM respective inhibitor).

Biochem/physiol Actions

p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Preparation Products And Raw materials

Raw materials

Preparation Products

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PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]- Suppliers

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1638-41-1, PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-Related Search:

4-Nitrobenzenesulfonyl chloride Dichlorophen 1,3-dichloro-5-(methylsulphonyl)benzene 2,3-DICHLOROTHIOPHENOL Bithionol 3,5-DICHLOROTHIOANISOLE 2-(METHYLSULFONYL)PHENOL BIS(2-HYDROXY-5-CHLOROPHENYL) SULFIDE BITHIONOL SULFOXIDE 4-CHLORO-2-[(5-CHLORO-2-HYDROXYPHENYL)SULFONYL]PHENOL 1,4-DICHLORO-2-(METHYLSULFONYL)BENZENE PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-

PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-

2,2'-Sulfonylbis(3,4,6-trichlorophenol)

p38 MAP Kinase Inhibitor IV

p38 MAPK Inhibitor IV

p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem

Phenol, 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)sulfonyl]-

p38 MAP Kinase Inhibitor IV (B10)

p38 MAP Kinase Inhibitor IV,p-38 MAP Kinase Inhibitor IV

1638-41-1

C12H4Cl6O4S