Cycloastragenol

ChemicalBook > CAS DataBase List > Cycloastragenol

Product Name: Cycloastragenol
CAS No.: 78574-94-4
Chemical Name: Cycloastragenol
Synonyms: Cyclosieversigenin;Cyclogalegenol;purity;cycloastragenol;Astramembrangenin;CYCLOASTRAGENOL(SH);Cycloastragenol Powder;Astragalus Root Extract Cycloastragenol;Cycloastragenol, 98%, from Astragalus membranaceus Bunge;Cycloastragenol（Cyclosiversigenin,Astramembrangenin,Cyclosieversigenin）
CBNumber: CB22457569
Molecular Formula: C30H50O5
Formula Weight: 490.72
MOL File: 78574-94-4.mol

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Cycloastragenol Property

Melting point:: 241.0 to 245.0 °C
Boiling point:: 617.2±55.0 °C(Predicted)
Density: 1.20±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: Sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, first dissolve in DMF and then dilute with the aqueous buffer of choice. Cycloastragenol has a solubility of approximately 0.25 mg/ml in a 1:8 solution of DMF:PBS (pH 7.2) using this method.Solubility in DMSO is 98 mg/mL (199.7 mM)
form: powder to crystal
pka: 14.57±0.29(Predicted)
color: White to Almost white
InChI: InChI=1/C30H50O5/c1-24(2)20(33)8-11-30-16-29(30)13-12-26(5)23(28(7)10-9-21(35-28)25(3,4)34)18(32)15-27(26,6)19(29)14-17(31)22(24)30/h17-23,31-34H,8-16H2,1-7H3/t17-,18-,19-,20-,21+,22-,23-,26+,27-,28+,29-,30+/s3
InChIKey: WENNXORDXYGDTP-XWIGRFCYNA-N
SMILES: [C@@]1(C)(O[C@H](CC1)C(C)(C)O)[C@@]1([H])[C@@H](O)C[C@]2(C)[C@]1(C)CC[C@@]13C[C@@]41[C@@]([H])([C@@H](O)C[C@]32[H])C(C)(C)[C@@H](O)CC4 |&1:0,3,10,12,15,17,21,23,24,26,29,34,r|

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Safety

RTECS: GX8265000
HS Code: 2932.19.5100

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL82509
Product name: Cycloastragenol
Purity: phyproof?ReferenceSubstance
Packaging: 10mg
Price: $480
Updated: 2024/03/01

TCI Chemical

Product number: C3469
Product name: Cycloastragenol
Packaging: 25mg
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: C3469
Product name: Cycloastragenol
Packaging: 100mg
Price: $89
Updated: 2024/03/01

TRC

Product number: C987618
Product name: Cycloastragenol
Packaging: 100mg
Price: $125
Updated: 2021/12/16

Chem-Impex

Product number: 36989
Product name: Cycloastragenol,≥99%(HPLC)
Purity: ≥99%(HPLC)
Packaging: 5G
Price: $946.4
Updated: 2021/12/16

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Cycloastragenol Chemical Properties,Usage,Production

Description

Cycloastragenol is the genuine sapogenin of astragaloside IV, a major bioactive constituent of the Chineseherbal medicine Astragali Radix (Huang-Qi). Astragaloside IV exhibits various pharmacological properties, suchas anti-viral, anti-inflammatory, anti-aging,and antioxidant activities.Cycloastragenol is a telomerase activator,which delays the onset of cellularaging. Thus, cycloastragenol is considered as a newgeneration of anti-aging agent.

Uses

Cycloastragenol, a saponin and aglycone found in Astragalus, is a natural triterpenoid. It has anti-aging properties and can also act as an adjuvant therapy for cancer by enhancing the effectiveness of anti-cancer drugs, reducing their toxicity, and preventing/treating leukopenia caused by these treatments.

Definition

ChEBI: Cycloastragenol is a sapogenin that is the aglycone derivative of astragaloside IV, a major saponin extracted from the root of Astragalus membranaceus. It has a role as a metabolite. It is a sapogenin, a pentacyclic triterpenoid, a tetrol and a member of oxolanes. It derives from a hydride of a 5alpha-gonane.

Preparation

The cycloastragenol was prepared by acid hydrolysis, and the oxidation reaction was carried out before the hydrolysis. The technological process is: oxidation-reduction-hydrolysis-extraction.

benefits

Cycloastragenol has a steroidal skeleton of tetracyclic triterpene and possess diverse pharmacological activities such as anti-aging, anti-inflammatory, anti-fibrosis, pro-wound healing, liver protection and endothelial protection.
A comprehensive review of cycloastragenol: Biological activity, mechanism of action and structural modifications

Biological Activity

Cycloastragenol(78574-94-4), a natural tetracyclic triterpenoid, was first identified when screening Astragalus membranaceus extracts for active ingredients with antiaging properties. IC50 value:Target:In vitro: In the study of Cycloastragenolon the treatment of degenerative diseases, the result showed that first-pass intestinal metabolism of cycloastragenol might occur upon passage through the intestinal epithelium. Cycloastragenol underwent extensive metabolism in rat and human liver microsomes with only 17.4% and 8.2%, respectively, of the starting amount of Cycloastragenol remaining after 30 min of incubation [1]. The present study demonstrates that cycloastragenol stimulates telomerase activity and cell proliferation in human neonatal keratinocytes. In particular, cycloastragenol promotes scratch wound closure of human neonatal keratinocyte monolayers in vitro [3]. In vivo: Rats were treated with Cycloastragenol (40 mg·kg- 1·d- 1) for 7 days to induce hepatic microsomal enzyme. The result showed that compared with the control, cycloastragenol obviously activated CYP2E1, and remarkably inhibited CYP3A4 [2].

Biochem/physiol Actions

Cycloastragenol is used as a nutraceutical (e.g. TAT2) and seems to moderately increase the telomerase activity and proliferative capacity of both CD4 and CD8 T-cells. Cycloastragenol possesses antiviral, antimicrobial, anti-inflammatory, anti-hepatotoxic, anti-leukemia, antitumor and antinociceptive activity. It also acts as an immunomodulator.

Side effects

Cycloastragenol is a telomerase activator. Fortunately, the experimental results did not show an increased risk of cancer and other adverse effects.

Source

Cycloastragenol is isolated from Astragalus species.

Dosage

As a dietary supplement, take one 100mg capsule of Cycloastragenol daily.

References

[1]. Jing Zhu, et al. In vitro Intestinal Absorption and First-pass Intestinal and Hepatic Metabolism of Cycloastragenol, a Potent Small Molecule Telomerase Activator. Drug Metabolism and PharmacokineticsVolume 25, Issue 5, 2010, Pages 477-486
[2]. WEI Bao-hong, et al. Effect of continuous oral cycloastragenol on the activity of cytochrome P450 enzymes in rats. Chinese New Drugs Journal, 2014 -04
[3]. Ip FC, et al. Cycloastragenol is a potent telomerase activator in neuronal cells: implications for depression management. Neurosignals. 2014;22(1):52-63.

Cycloastragenol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Cycloastragenol manufacturers

Sinoway Industrial co., ltd.

Product: Cycloastragenol 78574-94-4
Price: US $0.00-0.00/G
Min. Order: 100G
Purity: 98% up, High Density
Supply Ability: 20 tons
Release date: 2024-06-27

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Cycloastragenol Powder 78574-94-4
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-18

Chengdu King-tiger Pharm-chem. Tech. Co., Ltd.

Product: Cycloastragenol 78574-94-4
Price: US $260.00-22480.00/g
Min. Order: 10g
Purity: 1%-99%
Supply Ability: 1000kg
Release date: 2024-09-20

78574-94-4, CycloastragenolRelated Search:

Astraisoflavan-7--O--β-D-glucoside ASTRAGALOSIDE I β-D-Glucopyranoside,(3β,6α,16β,20R,24S)-3-[(3,4-di-O-acetyl-β-D-xylopyranosyl)oxy]-20, 24-epoxy-16,25-dihydroxy-9,19-cyclolanostan-6-yl Astraganoside Formononetin CALYCOSIN Isoastragaloside II cycloastragenol CALYCOSIN 7-O-GLUCOSIDE Astragaloside IV Isoastragaloside IV Isoastragaloside I Astragaloside II Astragaloside III Methylnissolin Ononin

(3beta,6alpha,16beta,20R,24S) 20,24-Epoxy-9,19-cyclolanostane-3,6,16,25-tetrol

Astramembrangenin

Cyclosieversigenin

CYCLOASTRAGENOL(SH)

Cycloastragenol, 98%, from Astragalus membranaceus Bunge

Cyclogalegenol

Cycloastragenol（Cyclosiversigenin,Astramembrangenin,Cyclosieversigenin）

9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,16β,20R,24S)-

(2aR,3R,4S,5aS,5bS,7S,7aR,9S,11aR,12aS)-3-((2R,5S)-5-(2-hydroxypropan-2-yl)-2-methyltetrahydrofuran-2-yl)-2a,5a,8,8-tetramethylhexadecahydrocyclopenta[a]cyclopropa[e]phenanthrene-4,7,9-triol

cycloastragenol

purity

Astragalus Root Extract Cycloastragenol

9,19-Cyclolanostane-3,6,16,25-tetrol, 20,24-epoxy-, (3β,6α,16β,20R,24S)-

Cycloastragenol Powder

78574-94-4