ChemicalBook > CAS DataBase List > OPHIOPOGONIN D

OPHIOPOGONIN D

Product Name: OPHIOPOGONIN D
CAS No.: 65604-80-0
Chemical Name: OPHIOPOGONIN D
Synonyms: Ophiopogonin D';Ophiopogonin D'';3)]-β-D-glucopyranoside;Ophiopogonin D'', 10 mM in DMSO;Sirtuin,inhibit,Ophiopogonin D',Inhibitor;(3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->(3beta,25R)-spirost-5-en-3-yl 6-deoxy-alpha-L-mannopyranosyl...;Diosgenin 3-O-[alpha-L-rhamnopyranosyl-(1-2)][beta-D-xylopyranosyl-(1-3)]-beta-D-glucopyranoside;(3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-β-D-glucopyranoside;β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-
CBNumber: CB22464521
Molecular Formula: C44H70O16
Formula Weight: 855.02
MOL File: 65604-80-0.mol

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OPHIOPOGONIN D Property

Density: 1.40
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 12.78±0.70(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: N2001
Product name: OphiopogoninD'
Packaging: 10mg
Price: $300
Updated: 2021/12/16

ChemScene

Product number: CS-0023669
Product name: OphiopogoninD'
Purity: 99.85%
Packaging: 5mg
Price: $514
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: D74089
Product name: OphiopogoninD?
Purity: 98%
Packaging: 20mg
Price: $733
Updated: 2021/12/16

Arctom

Product number: CFN90503
Product name: OphiopogoninD'
Packaging: 10mg
Price: $288
Updated: 2021/12/16

AvaChem

Product number: 2128
Product name: Ophiopogonin D'
Packaging: 5mg
Price: $290
Updated: 2021/12/16

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OPHIOPOGONIN D Chemical Properties,Usage,Production

Chemical Properties

White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Ophiopogon japonicus.

Uses

Ophiopogonin D', isolated from the tubers of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D' shows cytotoxic activity against two human tumor cell lines MG-63 and SNU387 with IC50s of 3.09 μM and 3.63 μM, respectively[1]. Ophiopogonin D' activates SIRT1 in a dose-dependent manner[2].

Biological Activity

Ophiopogonin D, isolated from the tuber of Ophiopogon japonicus, is a rare naturally occurring C29 steroidal glycoside. Ophiopogonin D' has cytotoxic activity against two human tumor cell lines, MG-63 and SNU387, with IC50s of 3.09 μM and 3.63 μM, respectively.

target

SIRT1

IC 50

SIRT1

References

[1] Wang L , et al. Homo-aro-cholestane, furostane and spirostane saponins from the tubers of Ophiopogonjaponicus. Phytochemistry. 2017 Apr;136:125-132. DOI:10.1016/j.phytochem.2017.01.006
[2] Wang Y, et al. Specific Turn-On Fluorescent Probe with Aggregation-Induced EmissionCharacteristics for SIRT1 Modulator Screening and Living-Cell Imaging. Anal Chem. 2015;87(10):5046-9. DOI:10.1021/acs.analchem.5b01069

OPHIOPOGONIN D Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from OPHIOPOGONIN D manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Ophiopogonin D' 65604-80-0
Price: US $0.00/mg
Min. Order: 10mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2020-05-07

Career Henan Chemical Co

Product: OPHIOPOGONIN D 65604-80-0
Price: US $16.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1kg, 10kg, 50kg
Release date: 2020-03-09

65604-80-0, OPHIOPOGONIN DRelated Search:

OPHIOPOGONIN D OPHIOPOGONIN C Methylophiopogonone A Celosin K Epigomisin O Benzoylgomisin O Ophiopogonin A Celosin H Glycoside O-4 Methylophiopogonanone B (6S,7S,12aR)-5,6,7,8-Tetrahydro-2,3,10,11,12-pentamethoxy-6,7-dimethyldibenzo[a,c]cyclooctene-1,7-diol Methylophiopogonanone A Liriopeside B RUSCOGENIN 27-Hydroxycholesterol Diosgenin 22(R)-HYDROXYCHOLESTEROL OPHIOPOGONIN D

Diosgenin 3-O-[alpha-L-rhamnopyranosyl-(1-2)][beta-D-xylopyranosyl-(1-3)]-beta-D-glucopyranoside

(3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1-&gt

3)]-β-D-glucopyranoside

(3β,25R)-Spirost-5-en-3-yl 6-deoxy-α-L-mannopyranosyl-(1->2)-[β-D-xylopyranosyl-(1->3)]-β-D-glucopyranoside

β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-xylopyranosyl-(1→3)]-

(3beta,25R)-spirost-5-en-3-yl 6-deoxy-alpha-L-mannopyranosyl...

Sirtuin,inhibit,Ophiopogonin D',Inhibitor

Ophiopogonin D'

Ophiopogonin D''

Ophiopogonin D'', 10 mM in DMSO

(2S,3R,4R,5R,6S)-2-(((2R,3R,4S,5R,6R)-5-Hydroxy-6-(hydroxymethyl)-2-(((4S,5'R,6aR,6bS,8aS,8bR,9S,10R,11aS,12aS,12bS)-5',6a,8a,9-tetramethyl-1,3,3',4,4',5,5',6,6a,6b,6',7,8,8a,8b,9,11a,12,12a,12b-icosahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-pyran]-4-yl)oxy)-4-(((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-3-yl)oxy)-6-methyltetrahydro-2H-pyran-3,4,5-triol

65604-80-0

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract