3-FLUORO-5-METHOXY-PHENOL

Product Name: 3-FLUORO-5-METHOXY-PHENOL
CAS No.: 850793-25-8
Chemical Name: 3-FLUORO-5-METHOXY-PHENOL
Synonyms: 3-FLUORO-5-METHOXY-PHENOL;Phenol, 3-fluoro-5-methoxy-
CBNumber: CB22464899
Molecular Formula: C7H7FO2
Formula Weight: 142.13
MOL File: 850793-25-8.mol

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3-FLUORO-5-METHOXY-PHENOL Property

Boiling point:: 222.0±20.0 °C(Predicted)
Density: 1.224±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 8.59±0.10(Predicted)
Appearance: White to off-white Solid

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Safety

HS Code: 2909500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TRC

Product number: F597533
Product name: 3-Fluoro-5-methoxyphenol
Packaging: 1g
Price: $75
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2607-3-63
Product name: 3-Fluoro-5-methoxy-phenol
Purity: 95%
Packaging: 250mg
Price: $395
Updated: 2021/12/16

Matrix Scientific

Product number: 075863
Product name: 3-Fluoro-5-methoxyphenol
Purity: 95+%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

AK Scientific

Product number: W8785
Product name: 3-FLUORO-5-METHOXY-PHENOL
Packaging: 10g
Price: $264
Updated: 2021/12/16

Matrix Scientific

Product number: 075863
Product name: 3-Fluoro-5-methoxyphenol
Purity: 95+%
Packaging: 1g
Price: $500
Updated: 2021/12/16

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3-FLUORO-5-METHOXY-PHENOL Chemical Properties,Usage,Production

Uses

3-Fluoro-5-methoxyphenol is a useful research chemical used in the preparation of tetracyclicindole derivatives for hepatitis c treatment as well as biaryl ethers as reverse transcriptase inhibitors.

Synthesis

52189-63-6

850793-25-8

Example 50: Synthesis of 3-{5-[(6-amino-1H-pyrazolo[3,4-b]pyridin-3-yl)methoxy]-2-chloro-3-fluorophenoxy}-5-chlorobenzenecarbonitrile; Step 1: Preparation of 3-fluoro-5-methoxyphenol (50-1); Under nitrogen protection, 1-fluoro-3,5-dimethoxybenzene (25 g, 160 mmol) was dissolved in dichloromethane ( 200 mL, 0.8 M) and subsequently cooled to -15 °C. Boron tribromide (176 mL, 176 mmol, 1 M solution in dichloromethane) was added slowly. The reaction mixture was stirred at -15 °C for 1.5 h, followed by stirring at room temperature for 10 min. The reaction mixture was cooled again to 0 °C and the reaction was quenched by slowly adding water (150 mL). The aqueous layer was extracted with dichloromethane (3 x 100 mL). The organic layers were combined, dried over sodium sulfate and concentrated. Purification by silica gel column chromatography (1%-30% ethyl acetate/hexane) afforded the mono-demethylated product 3-fluoro-5-methoxyphenol (50-1) (15 g, 67% yield).

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 22, p. 7163 - 7169
[2] Patent: US2007/21442, 2007, A1. Location in patent: Page/Page column 57-58
[3] Patent: WO2007/34325, 2007, A1. Location in patent: Page/Page column 48
[4] Patent: WO2005/37763, 2005, A1. Location in patent: Page/Page column 94-95
[5] Patent: US2015/191473, 2015, A1. Location in patent: Paragraph 0173

3-FLUORO-5-METHOXY-PHENOL Preparation Products And Raw materials

Raw materials

Nitrogen 3,5-Dimethoxyaniline Sodium sulfate Boron tribromide Sodium nitrite Fluoroboric acid Diethyl ether Ethyl acetate Dichloromethane PETROLEUM ETHER

Preparation Products

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3-FLUORO-5-METHOXY-PHENOL Suppliers

China 53 India 1 United Kingdom 1 United States 8 Global 63

Shanghai Hanhong Scientific Co.,Ltd.

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850793-25-8, 3-FLUORO-5-METHOXY-PHENOLRelated Search:

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3-FLUORO-5-METHOXY-PHENOL

Phenol, 3-fluoro-5-methoxy-

850793-25-8