3-broMo-5-iodo-phenol
- Product Name
- 3-broMo-5-iodo-phenol
- CAS No.
- 570391-20-7
- Chemical Name
- 3-broMo-5-iodo-phenol
- Synonyms
- 3-broMo-5-iodo-phenol;Phenol, 3-bromo-5-iodo-
- CBNumber
- CB52721430
- Molecular Formula
- C6H4BrIO
- Formula Weight
- 298.9
- MOL File
- 570391-20-7.mol
3-broMo-5-iodo-phenol Property
- Melting point:
- 82.5 °C
- Boiling point:
- 324.2±32.0 °C(Predicted)
- Density
- 2.369±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 8.15±0.10(Predicted)
- form
- crystalline needles
- color
- Light golden brown
Safety
- HS Code
- 2908190090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B683900
- Product name
- 3-Bromo-5-iodophenol
- Packaging
- 100mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- OR46047
- Product name
- 3-Bromo-5-iodophenol
- Packaging
- 250mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR46047
- Product name
- 3-Bromo-5-iodophenol
- Packaging
- 1g
- Price
- $167
- Updated
- 2021/12/16
- Product number
- 2601-S-05
- Product name
- 3-Bromo-5-iodophenol
- Packaging
- 1g
- Price
- $184
- Updated
- 2021/12/16
- Product number
- Y1511
- Product name
- 3-Bromo-5-iodo-phenol
- Packaging
- 1g
- Price
- $264
- Updated
- 2021/12/16
3-broMo-5-iodo-phenol Chemical Properties,Usage,Production
Uses
3-Bromo-5-iodophenol is a reactant in the preparation of N-[3-(1H-Indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl]methanesulfonamide (LP-261), a potent antimitotic agent.
Synthesis
915412-18-9
570391-20-7
General procedure for the synthesis of 3-bromo-5-iodophenol from 1-bromo-3-iodo-5-methoxybenzene: 1-bromo-3-iodo-5-methoxybenzene (6.29 g, 20.1 mmol) was suspended in a 33% hydrogen bromide solution in acetic acid (150 mL). Tetrabutylammonium bromide (0.5 g, 1.55 mmol) was added and the mixture was heated to reflux with vigorous stirring and the reaction continued for 2 days. After completion of the reaction, the mixture was cooled to room temperature and extracted with dichloromethane (3 × 100 mL). The organic layers were combined, washed with water (50 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the crude product. The crude product was purified by rapid chromatography on silica gel (300 g of silica gel, eluent ethyl acetate/heptane 1:9) to afford 3-bromo-5-iodophenol (21.2 g, 96% yield) as a light brown solid.
References
[1] Patent: US2006/270686, 2006, A1. Location in patent: Page/Page column 41
[2] Patent: US2008/280891, 2008, A1. Location in patent: Page/Page column 41
[3] Patent: WO2008/8059, 2008, A1. Location in patent: Page/Page column 117
3-broMo-5-iodo-phenol Preparation Products And Raw materials
Raw materials
Preparation Products
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