3-AMINO-5-CHLOROPHENOL

Product Name: 3-AMINO-5-CHLOROPHENOL
CAS No.: 883195-40-2
Chemical Name: 3-AMINO-5-CHLOROPHENOL
Synonyms: 3-AMINO-5-CHLOROPHENOL;Phenol, 3-amino-5-chloro-
CBNumber: CB31416012
Molecular Formula: C6H6ClNO
Formula Weight: 143.57
MOL File: 883195-40-2.mol

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3-AMINO-5-CHLOROPHENOL Property

storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A619595
Product name: 3-Amino-5-chlorophenol
Packaging: 250mg
Price: $160
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA166354
Product name: 3-?Amino-?5-?chlorophenol
Packaging: 500mg
Price: $200
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0364336
Product name: 3-AMINO-5-CHLOROPHENOL
Purity: 95.00%
Packaging: 250MG
Price: $271.95
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA166354
Product name: 3-?Amino-?5-?chlorophenol
Packaging: 1g
Price: $325
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA166354
Product name: 3-?Amino-?5-?chlorophenol
Packaging: 100mg
Price: $80
Updated: 2021/12/16

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3-AMINO-5-CHLOROPHENOL Chemical Properties,Usage,Production

Uses

3-Amino-5-chlorophenol is a useful compound for studying the recyclization with benzoxazinones.

Synthesis

618-63-3

883195-40-2

General procedure for the synthesis of 3-amino-5-chlorophenol from 3-chloro-5-nitrophenol: 3-chloro-5-nitrophenol (3.00 g, 17.3 mmol) and zinc powder (5.65 g, 86.4 mmol) were dissolved in ethanol (80 mL) and heated to 60 °C. Subsequently, an aqueous solution of ammonium chloride (1.85 g, 34.6 mmol) was added dropwise to the reaction system (16 mL). The reaction temperature was maintained at 60 °C and stirring was continued for 3 hours. Upon completion of the reaction, the reaction mixture was filtered through Celite and the solvent was removed under vacuum. The residue was dissolved in water and extracted with ethyl acetate. The organic layer was dried with sodium sulfate and the solvent was again removed under vacuum. The residue was ground with dichloromethane and the precipitate was collected by filtration to give 1.97 g of 3-amino-5-chlorophenol in yellow crystalline form (77% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6): δ= 5.25 (broad single peak, 2H), 5.92 (double peak, 2H), 6.03 (triple peak, 1H), and 9.29 (single peak, 1H).Results of the LC/MS (Method 4) analysis: retention time R1 = 1.07 min; MS (ESIpos): m/z = 144 [M + H]+.

References

[1] Patent: WO2009/33581, 2009, A1. Location in patent: Page/Page column 95-96
[2] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5162 - 5192
[3] Patent: CN106831614, 2017, A. Location in patent: Paragraph 0484-0486
[4] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1964 - 1978
[5] Biochemical Journal, 1956, vol. 64, p. 38,39

3-AMINO-5-CHLOROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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3-AMINO-5-CHLOROPHENOL Suppliers

China 39 India 1 United Kingdom 1 United States 3 Global 44

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883195-40-2