5-Amino-2-fluorophenol

Product Name: 5-Amino-2-fluorophenol
CAS No.: 100367-48-4
Chemical Name: 5-Amino-2-fluorophenol
Synonyms: 5-Amino-2-fluorophenol;Phenol, 5-amino-2-fluoro-;4-Fluoro-3-hydroxyaniline;5-Amino-2-fluorophenol,97%;5-Amino-2-fluorophenol 95+%;2-(1,1-dimethyl-2-hydroxyethyl)-1,3-dioxolane
CBNumber: CB62527835
Molecular Formula: C6H6FNO
Formula Weight: 127.12
MOL File: 100367-48-4.mol

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5-Amino-2-fluorophenol Property

Melting point:: 156-158℃
Boiling point:: 255.3±20.0 °C(Predicted)
Density: 1.347±0.06 g/cm3(Predicted)
storage temp.: 2-8°C, protect from light, stored under nitrogen
form: Solid
pka: 8.76±0.10(Predicted)
color: White to yellow

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Safety

HazardClass: IRRITANT
HS Code: 2922290090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: A630993
Product name: 5-Amino-2-fluorophenol
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: A630993
Product name: 5-Amino-2-fluorophenol
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Apolloscientific

Product number: PC8698
Product name: 5-Amino-2-fluorophenol
Purity: 95+%
Packaging: 1g
Price: $114
Updated: 2021/12/16

Matrix Scientific

Product number: 056369
Product name: 5-Amino-2-fluorophenol
Purity: >95%
Packaging: 500mg
Price: $125
Updated: 2021/12/16

Matrix Scientific

Product number: 056369
Product name: 5-Amino-2-fluorophenol
Purity: >95%
Packaging: 1g
Price: $157
Updated: 2021/12/16

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5-Amino-2-fluorophenol Chemical Properties,Usage,Production

Uses

5-Amino-2-fluorophenol is used as synthetic building block.

Synthesis

64465-53-8

100367-48-4

Example 9A Step 1: 4-Fluoro-3-methoxyaniline (2.0 g, 14.2 mmol) was dissolved in dichloromethane (20 mL) at 0 °C and a dichloromethane solution of 1.0 M boron tribromide (40 mL) was slowly added dropwise. The reaction mixture was stirred at 0 °C, followed by gradual warming to room temperature and continued stirring overnight. Upon completion of the reaction, the reaction was quenched by the addition of methanol, followed by removal of the solvent under reduced pressure. Water was added to the residue, which was alkalized with saturated sodium bicarbonate solution to pH neutral and then extracted with ethyl acetate. The organic phase was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 5-amino-2-fluorophenol as a white solid (1.3 g, 73% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 9.26 (s, 1H), 6.81 (dd, 1H), 6.34 (dd, 1H), 6.04 (dd, 1H), 4.63 (br, 2H).

References

[1] Patent: WO2009/117080, 2009, A1. Location in patent: Page/Page column 171
[2] Patent: US2002/198194, 2002, A1
[3] Patent: WO2011/119704, 2011, A1. Location in patent: Page/Page column 45

5-Amino-2-fluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Amino-2-fluorophenol Suppliers

China 48 United Kingdom 1 United States 5 Global 54

Alfa Aesar

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100367-48-4, 5-Amino-2-fluorophenolRelated Search:

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5-Amino-2-fluorophenol 95+%

5-Amino-2-fluorophenol

2-(1,1-dimethyl-2-hydroxyethyl)-1,3-dioxolane

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5-Amino-2-fluorophenol,97%

100367-48-4